Results 131 to 140 of about 22,193 (229)
The Interface Between ER and Mitochondria: Molecular Compositions and Functions [PDF]
, 2018 Mitochondria and endoplasmic reticulum (ER) are essential organelles in eukaryotic cells, which play key roles in various biological pathways. Mitochondria are responsible for ATP production, maintenance of Ca2+ homeostasis and regulation of apoptosis ...
Lee, Soyeon, Min, Kyung-Tai
core +1 more source
Frontiers in Physiology, 2019 Tubulin is a well-established target of microtubule-targeting agents (MTAs), a widely used class of chemotherapeutic drugs. Yet, aside from their powerful anti-cancer efficiency, MTAs induce a dose-limiting and debilitating peripheral neurotoxicity ...
Amandine Rovini
doaj +1 more source
Pixelated Geiger-Mode Avalanche Photo-Diode Characterization through Dark Current Measurement
, 2013 PIXELATED geiger-mode avalanche photodiodes(PPDs), often called silicon photomultipliers (SiPMs) are emerging as an excellent replacement for traditional photomultiplier tubes (PMTs) in a variety of detectors, especially those for subatomic physics ...
Amaudruz, Pierre-André +11 more
core +1 more source
Role of cysteines in mammalian VDAC isoforms' function
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2016 In this mini-review, we analyze the influence of cysteines in the structure and activity of mitochondrial outer membrane mammalian VDAC isoforms. The three VDAC isoforms show conserved sequences, similar structures and the same gene organization. The meaning of three proteins encoded in different chromosomes must thus be searched for subtle differences
DE PINTO, Vito Nicola +4 more
openaire +2 more sources
Scientific Reports, 2017 Mycobacterium avium subsp. hominissuis is associated with infection of immunocompromised individuals as well as patients with chronic lung disease. M. avium infects macrophages and actively interfere with the host killing machinery such as apoptosis and ...
Lia Danelishvili +4 more
doaj +1 more source
Ekspresi Gen Family Bcl-2 dan Ekspresi Gen Protein Kanal Ion Vdac1 pada Oligozoospermia
Jurnal Kesehatan Andalas, 2014 AbstrakSalah satu bentuk infertilitas pada pria adalah jumlah spermatozoa yang kurang dari normal (Oligozoospermia). Berbagai mekanisme diduga berperan dalam terjadinya oligozoospermia, mulai dari faktor fisik, stress, makanan dan molekuler.
Arni Amir
doaj
The VDAC channel: Molecular basis for selectivity
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2016 The voltage dependent anion-selective channel, VDAC, is the major permeability pathway by which molecules and ion cross the mitochondrial outer membrane. This pathway has evolved to optimize the flow of these substances and to control this flow by a gating process that is influenced by a variety of factors including transmembrane voltage.
openaire +2 more sources
Mitoparans: mitochondriotoxic cell penetrating peptides and novel inducers of apoptosis. [PDF]
, 2007 Acknowledgments The authors would like to thank Keith Holding at the University of Wolverhampton for his outstanding technical support. This work was supported in part by Samantha Dickson Brain Tumour Trust.Introduction: The amphipathic helical peptide ...
Belzacq-Casagrande, Anne-Sophie +4 more
core +1 more source
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2016 Mitochondrial energy in cardiac cells has been reported to be channeled into the cytosol through the intermembrane contact sites formed by the adenine nucleotide translocator, creatine kinase and VDAC. Computational analysis performed in this study showed a high probability of the outer membrane potential (OMP) generation coupled to such a mechanism of
openaire +2 more sources
Fibroblast-Like Synoviocytes Glucose Metabolism as a Therapeutic Target in Rheumatoid Arthritis. [PDF]
, 2019 Metabolomic studies show that rheumatoid arthritis (RA) is associated with metabolic disruption that may be therapeutically targetable. Among them, glucose metabolism and glycolytic intermediaries seem to have an important role in fibroblast-like ...
de Oliveira, Patricia Gnieslaw +4 more
core +1 more source