Results 111 to 120 of about 14,744 (224)
Specific VDAC inhibitors: phosphorothioate oligonucleotides
, 2020 VDAC channels are ancient, highly-conserved voltage-gated channels in the mitochondrial outer membrane. They are the pathways by which metabolites travel between the cytosol and mitochondria.
Marco Colombini, C A Stein
core
Protein Science, Volume 35, Issue 6, June 2026.Abstract Mitochondrial cristae architecture is central for optimal oxidative phosphorylation and a healthy mitochondrial physiology. The intricate architecture of the inner mitochondrial membrane relies on protein complexes that compartmentalize the membrane by imposing membrane curvature, forming membrane contact sites or membrane subdomains ...
Patrick Horten +3 more
wiley +1 more source
VDAC: the wizard of mitochondrial OM
, 2014 Voltage dependent anion channels (VDAC) are the most abundant proteins in the outer mitochondrial membrane. Although they are essential in metabolite exchange, cell defense and apoptosis, the molecular mechanism of these VDAC-mediated processes remains ...
Psakis, Georgios +3 more
core +1 more source
The Mechanism of NLRP3 Inflammasome Activation and Its Roles in Chronic Rhinosinusitis
World Journal of Otorhinolaryngology - Head and Neck Surgery, Volume 12, Issue 3, Page 362-373, June 2026.ABSTRACT NLRP3 (NLR family pyrin domain containing 3) is one of the crucial receptors in pathogen recognition receptor (PRR) families which can recognize the pathogen‐associated molecular patterns (PAMPs) and the damage‐associated molecular patterns (DAMPs), thus triggering innate immune response. After NLRP3 activation, it recruits the adaptor protein
Dong‐Lin Li +4 more
wiley +1 more source
VDAC Regulation by Cytosolic Proteins [PDF]
Biophysical Journal, 2009 Voltage-dependent anion channel VDAC, positioned on the interface between mitochondria and the cytosol, is at the control point of mitochondria life and death. This large channel plays the role of a “switch” that defines in which direction mitochondria will go: to normal respiration or to suppression of mitochondria metabolism that leads to apoptosis ...
openaire +1 more source
A preregistration for a study on value-driven attentional capture (VDAC) in a sustained attention ...
Shivang Shelat
core +1 more source
Blocking VDAC abolishes BNIP3-induced mitochondrial release of EndoG.
, 2014 A, Mitochondria (1 mg/ml) were incubated with a recombinant GST-BNIP3 in the presence of 0.3 mg/ml of an anti-VDAC antibody or normal rabbit IgG in control. Incubation with the trunked BNIP3 (BNIP3ΔTM) was used as a control.
Jiming Kong (143823) +2 more
core +1 more source
Mitochondrial DNA: A Key Alarmin Igniting the Inflammasome Fire in Health and Disease
Immunology, Volume 178, Issue 2, Page 218-230, June 2026.This review illustrates how mitochondrial DNA, released under cellular stress, acts as a key alarmin that ignites innate immune sensors, particularly inflammasomes and the cGAS‐STING pathway. This paper details how this sustained “inflammasome fire” fuels the progression of diverse inflammatory diseases, including neurodegeneration and metabolic ...
Woo Hyun Park
wiley +1 more source
PERSPECTIVE: organelle positioning as a principle of metabolic regulation and stress tolerance
The Plant Journal, Volume 126, Issue 6, June 2026.SUMMARY Plants have evolved elaborate acclimation strategies to withstand adverse environments, involving all levels of their function and organization. While macroscopic movements through differential growth that enable the physical re‐shaping and ‐positioning of organs have been a major field of study, the highly active dynamics of cell organelles ...
Alisdair R. Fernie +8 more
wiley +1 more source
VDAC blockage by phosphorothioate oligonucleotides and its implication in apoptosis
, 2012 Apoptosis is a crucial process that regulates the homeostasis of multicellular organisms. Impaired apoptosis contributes to cancer development, while enhanced apoptosis is detrimental in neurodegenerative diseases.
Wenzhi Tan, Tan, Wenzhi
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