Results 11 to 20 of about 14,744 (224)

VDAC in Retinal Health and Disease

Biomolecules
The retina, a tissue of the central nervous system, is vital for vision as its photoreceptors capture light and transform it into electrical signals, which are further processed before they are sent to the brain to be interpreted as images. The retina is
Ying Xu, Shanti R. Tummala, Xiongmin Chen, Noga Vardi   +3 more
doaj   +4 more sources

The Role of Lipids in VDAC Oligomerization [PDF]

Biophysical Journal, 2012
Evidence has accumulated that the voltage-dependent anion channel (VDAC), located on the outer membrane of mitochondria, plays a central role in apoptosis. The involvement of VDAC oligomerization in apoptosis has been suggested in various studies.
Betaneli, Viktoria, Petrov, Eugene P., Schwille, Petra   +2 more
openaire   +3 more sources

VDAC Genes Expression and Regulation in Mammals [PDF]

Frontiers in Physiology, 2021
VDACs are pore-forming proteins, coating the mitochondrial outer membrane, and playing the role of main regulators for metabolites exchange between cytosol and mitochondria. In mammals, three isoforms have evolutionary originated, VDAC1, VDAC2, and VDAC3.
Federica Zinghirino, Xena Giada Pappalardo, Angela Messina, Angela Messina, Giuseppe Nicosia, Vito De Pinto, Vito De Pinto, Vito De Pinto, Francesca Guarino, Francesca Guarino, Francesca Guarino   +10 more
doaj   +4 more sources

Modulation of Plant Mitochondrial VDAC by Phytosterols [PDF]

Biophysical Journal, 2010
We have investigated the effect of cholesterol and two abundant phytosterols (sitosterol and stigmasterol) on the voltage-dependent anion-selective channel (VDAC) purified from mitochondria of bean seeds (Phaseolus coccineus). These sterols differ by the degree of freedom of their lateral chain.
Mlayeh, Lamia, Chatkaew, Sunita, Léonetti, M, Homblé, Fabrice   +3 more
openaire   +4 more sources

Phosphorothioate Oligonucleotides Block the VDAC Channel [PDF]

Biophysical Journal, 2007
Proapoptotic phosphorothioate oligonucleotides such as G3139 (an 18-mer) induce Bcl-2-independent apoptosis, perhaps partly via direct interaction with VDAC and reduction of metabolite flow across the mitochondrial outer membrane. Here, we analyzed the interactions at the molecular level.
Tan, Wenzhi, Loke, Yue-Hin, Stein, C.A., Miller, Paul, Colombini, Marco   +4 more
openaire   +3 more sources

Identification and Characterization of VDAC Family in Maize

Plants, 2023
The voltage-dependent anion channel (VDAC) is the most abundant protein in the outer mitochondrial membrane (OMM) of all eukaryotes, having an important role in the communication between mitochondria and cytosol.
Carolina Rodríguez-Saavedra, Donají Azucena García-Ortiz, Andrés Burgos-Palacios, Luis Enrique Morgado-Martínez, Beatriz King-Díaz, Ángel Arturo Guevara-García, Sobeida Sánchez-Nieto   +6 more
doaj   +3 more sources

VDAC electronics: 1. VDAC-hexo(gluco)kinase generator of the mitochondrial outer membrane potential

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2014
The simplest mechanism of the generation of the mitochondrial outer membrane potential (OMP) by the VDAC (voltage-dependent anion channel)-hexokinase complex (VHC), suggested earlier, and by the VDAC-glucokinase complex (VGC), was computationally analyzed.
Lemeshko, Victor V.
openaire   +3 more sources

Elliptical β-barrel deformation underlies gating in VDAC1. [PDF]

Protein Sci
Abstract Gating by voltage‐dependent anion channels (VDAC) regulates mitochondrial metabolite flux, yet the structural mechanism underlying the open‐to‐closed transition remains unresolved. Here, we combine atomistic molecular dynamics (MD) simulations with double electron–electron resonance (DEER), using hydrostatic pressure as a reversible ...
Bergdoll L, Elgeti M, Belyaeva J, Zlobin A, Duneau JP, Hubbell W, Abramson J.   +6 more
europepmc   +2 more sources

VDAC—A Primal Perspective [PDF]

International Journal of Molecular Sciences, 2021
The evolution of the eukaryotic cell from the primal endosymbiotic event involved a complex series of adaptations driven primarily by energy optimization. Transfer of genes from endosymbiont to host and concomitant expansion (by infolding) of the endosymbiont’s chemiosmotic membrane greatly increased output of adenosine triphosphate (ATP) and placed ...
openaire   +2 more sources

VDAC Channels [PDF]

IUBMB Life, 2001
AbstractTrafficking of metabolites across the outer mitochondrial membrane is believed to be mediated primarily by the pore‐forming voltage‐dependent anion channel, VDAC (also known as mitochondrial porin). An expanding body of in vitro studies have strongly suggest that the pore formed by VDAC can be regulated in a number of ways that implicate it as ...
E, Blachly-Dyson, M, Forte
openaire   +2 more sources