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Microbiology Spectrum, 2023 Pseudomonas aeruginosa is a ubiquitous opportunistic pathogen that can cause a variety of acute and chronic infections. The bacterium is highly resistant to numerous antibiotics.
Xiaoya Wei +9 more
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Bacterial outer membrane vesicles in the fight against cancer. [PDF]
Chin Med J (Engl). Bacterial outer membrane vesicles (OMVs) are diminutive vesicles naturally released by Gram-negative bacteria. These vesicles possess distinctive characteristics that attract attention for their potential use in drug administration and immunotherapy in
Meng Y, Kong C, Ma Y, Sun J, Zhang G.
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Lipopolysaccharide Transport to the Bacterial Outer Membrane in Spheroplasts [PDF]
Journal of Biological Chemistry, 2005 The mechanism of lipopolysaccharide (LPS) transport in Gram-negative bacteria from the inner membrane to the outer membrane is largely unknown. Here, we investigated the possibility that LPS transport proceeds via a soluble intermediate associated with a periplasmic chaperone analogous to the Lol-dependent transport mechanism of lipoproteins.
Tefsen, B. +4 more
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Outer membrane permeabilization is an essential step in the killing of gram-negative bacteria by the lectin RegIIIβ. [PDF]
PLoS ONE, 2013 The C-type lectin RegIIIβ can kill certain Gram-positive and Gram-negative bacteria. The susceptibility of S. Typhimurium depends on the bacterial growth phase, i.e., bacteria from the logarithmic growth phase do bind RegIIIβ and are subsequently killed.
Tsuyoshi Miki, Wolf-Dietrich Hardt
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Bacterial Outer Membranes and Interactions with Membrane Proteins [PDF]
Biophysical Journal, 2015 Because the bacteria's outer membrane (OM) acts as an effective barrier against the permeation of both hydrophobic and hydrophilic compounds, gram-negative cell permeation is one of the biggest challenges to the discovery of novel antibiotics for bacterial infections and antibiotic resistance worldwide.
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Advanced Science, 2022 The blood–brain barrier (BBB) severely blocks the intracranial accumulation of most systemic drugs. Inspired by the contribution of the bacterial outer membrane to Escherichia coli K1 (EC‐K1) binding to and invasion of BBB endothelial cells in bacterial ...
Haiyan Chen +10 more
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HELICOBACTER PYLORI OIPA VIRULENCE GENE AS A MOLECULAR MARKER OF SEVERE GASTROPATHIES [PDF]
Arquivos de GastroenterologiaBackground: Helicobacter pylori is an etiologic agent of gastroduodenal diseases. The microorganism, considered a type I carcinogen, affects about 50% of the global population. H.
Diogo Nery MACIEL +4 more
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The Fluidity of the Bacterial Outer Membrane Is Species Specific
BioEssays, 2020 AbstractThe outer membrane (OM) is an essential barrier that guards Gram‐negative bacteria from diverse environmental insults. Besides functioning as a chemical gatekeeper, the OM also contributes towards the strength and stiffness of cells and allows them to sustain mechanical stress. Largely influenced by studies of Escherichia coli, the OM is viewed
Pengbo Cao, Daniel Wall
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Enzymology of lipid A palmitoylation in bacterial outer membranes [PDF]
Journal of Endotoxin Research, 2004 The enzymology of palmitate addition to lipid A can be traced to the early discovery of monosaccharide lipid A precursors, but the functional importance of lipid A palmitoylation in bacterial resistance to the host immune response has emerged only recently.
Ahmed El Zoeiby +4 more
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Knockout of mlaA increases Escherichia coli virulence in a silkworm infection model.
PLoS ONE, 2022 The mlaA gene encodes a lipoprotein to maintain an outer membrane lipid asymmetry in gram-negative bacteria. Although the role of mlaA in bacterial virulence has been studied in several bacterial species, there are no reports of its role in E.
Haruka Nasu +3 more
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