Results 21 to 30 of about 328,822 (337)

Bacterial outer membrane vesicle based versatile nanosystem boosts the efferocytosis blockade triggered tumor-specific immunity

Nature Communications, 2023
Efferocytosis inhibition is emerging as an attractive strategy for antitumor immune therapy because of the subsequent leak of abundant immunogenic contents.
Wanru Zhuang, Yunfeng Wang, Weidong Nie, Yao Lei, Chao Liang, Jiaqi He, Liping Zuo, Lili Huang, Hai‐Yan Xie   +8 more
semanticscholar   +1 more source

Antibiotics and hexagonal order in the bacterial outer membrane [PDF]

Nature Communications, 2023
Georgina Benn, Thomas J. Silhavy, Colin Kleanthous, Bart W. Hoogenboom   +3 more
doaj   +2 more sources

A modular vaccine platform enabled by decoration of bacterial outer membrane vesicles with biotinylated antigens

Nature Communications, 2023
Antigen display on outer membrane vesicles (OMVs) can be difficult to control and highly variable. Here, the authors describe a universal approach called AvidVax for linking biotinylated antigens to the exterior of OMVs and enabling rapid vaccine ...
Kevin B. Weyant, Ayomide Oloyede, S. Pal, Julie Liao, Mariela Rivera-De Jesus, Thapakorn Jaroentomeechai, Tyler D Moeller, Steven A. Hoang-Phou, Sean F Gilmore, Riya Singh, Daniel C. Pan, D. Putnam, Christopher P. Locher, L. M. de la Maza, M. Coleman, M. DeLisa   +15 more
semanticscholar   +1 more source

The role and mechanisms of gram-negative bacterial outer membrane vesicles in inflammatory diseases

Frontiers in Immunology, 2023
Outer membrane vesicles (OMVs) are spherical, bilayered, and nanosized membrane vesicles that are secreted from gram-negative bacteria. OMVs play a pivotal role in delivering lipopolysaccharide, proteins and other virulence factors to target cells ...
Shuoling Chen, Qian Lei, Xianghui Zou, Dandan Ma   +3 more
semanticscholar   +1 more source

Bacterial outer membrane vesicles-based therapeutic platform eradicates triple-negative breast tumor by combinational photodynamic/chemo-/immunotherapy

Bioactive Materials, 2022
Bacterial outer membrane vesicles (OMVs) are potent immuno-stimulating agents and have the potentials to be bioengineered as platforms for antitumor nanomedicine. In this study, OMVs are demonstrated as promising antitumor therapeutics.
Yongjiang Li, Junyong Wu, Xiaohan Qiu, S. Dong, Jun He, Jihua Liu, Wenjie Xu, Si Huang, Xiong-Bin Hu, Dang Xiang   +9 more
semanticscholar   +1 more source

The outer membrane phospholipase A is essential for membrane integrity and type III secretion in Shigella flexneri [PDF]

Open Biology, 2016
Outer membrane phospholipase A (OMPLA) is an enzyme located in the outer membrane of Gram-negative bacteria. OMPLA exhibits broad substrate specificity, and some of its substrates are located in the cellular envelope.
Xia Wang, Feng Jiang, Jianhua Zheng, Lihong Chen, Jie Dong, Lilian Sun, Yafang Zhu, Bo Liu, Jian Yang, Guowei Yang, Qi Jin   +10 more
doaj   +1 more source

Murepavadin induces envelope stress response and enhances the killing efficacies of β-lactam antibiotics by impairing the outer membrane integrity of Pseudomonas aeruginosa

Microbiology Spectrum, 2023
Pseudomonas aeruginosa is a ubiquitous opportunistic pathogen that can cause a variety of acute and chronic infections. The bacterium is highly resistant to numerous antibiotics.
Xiaoya Wei, Jiacong Gao, Congjuan Xu, Xiaolei Pan, Yongxin Jin, Fang Bai, Zhihui Cheng, Iain L. Lamont, Daniel Pletzer, Weihui Wu   +9 more
doaj   +1 more source

Bacterial outer membrane vesicles as potential biological nanomaterials for antibacterial therapy.

Acta Biomaterialia, 2021
Antibiotic therapy is one of the most important approaches against bacterial infections. However, the improper use of antibiotics and the emergence of drug resistance have compromised the efficacy of traditional antibiotic therapy.
Wenlong Huang, Lingxi Meng, Yuan-Feng Chen, Zaiquan Dong, Q. Peng   +4 more
semanticscholar   +1 more source

Biogenesis of the Gram-Negative Bacterial Outer Membrane [PDF]

Annual Review of Microbiology, 2007
The cell envelope of gram-negative bacteria consists of two membranes, the inner and the outer membrane, that are separated by the periplasm. The outer membrane consists of phospholipids, lipopolysaccharides, integral membrane proteins, and lipoproteins.
Bos, M.P., Robert, V.M.V., Tommassen, J.P.M.   +2 more
openaire   +7 more sources

The porin and the permeating antibiotic: A selective diffusion barrier in gram-negative bacteria [PDF]

, 2008
Gram-negative bacteria are responsible for a large proportion of antibiotic resistant bacterial diseases. These bacteria have a complex cell envelope that comprises an outer membrane and an inner membrane that delimit the periplasm.
A Baslé, A Baslé, A Bryskier, A Davin-Regli, A Davin-Régli, A Doménech-Sánchez, A Doménech-Sánchez, A Loli, A Mena, A Mena, A Prilipov, A Thiolas, A Thiolas, AA Medeiros, AH Delcour, AM Berezhkovskii, AM Giuliodori, AS Low, C Bornet, C Bornet, C Bosi, C Danelon, C Danelon, C Rodrigues, C Sheridan, Chloë E. James, D Jeanteur, D Szabó, DJ Wolter, E Dé, E Elliott, E Sugawara, EM Nestorovich, EM Nestorovich, F Yoshimura, FM Kaczmarek, G Schwarz, GA Jacoby, GE Schulz, H Nikaido, H Nikaido, H Nikaido, H Samartzidou, H Samartzidou, J Bredin, J Chevalier, J Chevalier, J-M Pagès, JC Cai, Jean-Marie Pagès, JM Bower, K Poole, L Kullman, L Martínez-Martínez, LB Rice, LJ Piddock, LP Randall, M Ceccarelli, M Guillier, M Luckey, M Malléa, M Olesky, M Olesky, M Viveiros, MA Kohanski, Mathias Winterhalter, MM Ochs, N El Amin, P Valentin-Hansen, R Dutzler, R Iyer, R Iyer, R Koebnik, RE Hancock, RN Charrel, S Biswas, S Blot, S Hernández-Allés, S Hernández-Allés, S Nekolla, S Vidal, S Vidal, SF Epp, SM Bezrukov, SM Bezrukov, SR Norrby, SW Cowan, T Ferenci, T Mach, UO Hasdemir, V Simonet, V Simonet, WL Veal, WM Shafer, WR Bauer, XZ Li   +95 more
core   +1 more source