Results 41 to 50 of about 202,274 (318)
β-Barrel Assembly Machinery (BAM) Complex as Novel Antibacterial Drug Target
Molecules, 2023 The outer membrane of Gram-negative bacteria is closely related to the pathogenicity and drug resistance of bacteria. Outer membrane proteins (OMPs) are a class of proteins with important biological functions on the outer membrane.
Qian Xu, Min Guo, Feiyuan Yu
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Dissecting Escherichia coli outer membrane biogenesis using differential proteomics. [PDF]
PLoS ONE, 2014 The cell envelope of Gram-negative bacteria is a complex multi-layered structure comprising an inner cytoplasmic membrane and an additional asymmetric lipid bilayer, the outer membrane, which functions as a selective permeability barrier and is essential
Alessandra M Martorana +7 more
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Not All Bacterial Outer-Membrane Proteins Are β-Barrels [PDF]
MicroPubl BiolThe discovery of Wza, an octomeric helical barrel integral bacterial outer-transmembrane protein, has challenged the widely held understanding that all integral outer-membrane proteins of Gram-negative bacteria are closed β-barrels composed of transmembrane β- strands.
Heido J +4 more
europepmc +3 more sources
BMC Genomics, 2009 Background Chlamydiae are obligate intracellular bacteria comprising some of the most important bacterial pathogens of animals and humans. Although chlamydial outer membrane proteins play a key role for attachment to and entry into host cells, only few ...
Myers Garry +5 more
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Frontiers in Microbiology, 2021 Antibiotic–adjuvant combinatory therapy serves as a viable treatment option in addressing antibiotic resistance in the clinical setting. This study was carried out to assess and characterize the adjuvant potential and mode of action of linalool against ...
Shun-Kai Yang +7 more
doaj +1 more source
Outer membrane vesicles: A bacterial-derived vaccination system
Frontiers in Microbiology, 2022 Outer membrane vesicles (OMVs) are non-living spherical nanostructures that derive from the cell envelope of Gram-negative bacteria. OMVs are important in bacterial pathogenesis, cell-to-cell communication, horizontal gene transfer, quorum sensing, and ...
L. Lieberman
semanticscholar +1 more source
Folding of a bacterial integral outer membrane protein is initiated in the periplasm [PDF]
Nature Communications, 2017 AbstractThe Bam complex promotes the insertion of β-barrel proteins into the bacterial outer membrane, but it is unclear whether it threads β-strands into the lipid bilayer in a stepwise fashion or catalyzes the insertion of pre-folded substrates.
Harris D. Bernstein +3 more
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Journal of Pharmaceutical Analysis, 2021 Mining of plant-derived antimicrobials is the major focus at current to counter antibiotic resistance. This study was conducted to characterize the antimicrobial activity and mode of action of linalyl anthranilate (LNA) against carbapenemase-producing ...
Shun-Kai Yang +5 more
doaj +1 more source
Assembly of β-barrel proteins into bacterial outer membranes
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2014 Membrane proteins with a β-barrel topology are found in the outer membranes of Gram-negative bacteria and in the plastids and mitochondria of eukaryotic cells. The assembly of these membrane proteins depends on a protein folding reaction (to create the barrel) and an insertion reaction (to integrate the barrel within the outer membrane).
Selkrig, Joel +3 more
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Acquisition of ionic copper by a bacterial outer membrane protein [PDF]
, 2020 AbstractCopper, while toxic in excess, is an essential micronutrient in all kingdoms of life due to its essential role in the structure and function of many proteins. Proteins mediating ionic copper import have been characterised in detail for eukaryotes, but much less so for prokaryotes. In particular, it is still unclear whether and how Gram-negative
van den Berg B +6 more
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