Results 101 to 110 of about 1,583,285 (309)

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Responses of a bacterial pathogen to phosphorus limitation of its aquatic invertebrate host [PDF]

, 2008
Host nutrition is thought to affect the establishment, persistence, and severity of pathogenic infections. Nutrient-deficient foods possibly benefit pathogens by constraining host immune function or benefit hosts by limiting parasite growth and ...
Ebert, Dieter, Frost, Paul C., Dieter Ebert, Smith, V. H., Frost, P. C., Smith, Val H., Val H. Smith, Dieter, Ebert, Paul C. Frost   +8 more
core   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Systematic determination of the mosaic structure of bacterial genomes: species backbone versus strain-specific loops [PDF]

, 2005
Background Public databases now contain multitude of complete bacterial genomes, including several genomes of the same species. The available data offers new opportunities to address questions about bacterial genome evolution, a task that requires ...
Petit M-A, El Karoui, Meriem, El Karoui, M, Bourgait, Isabelle, Gendrault-Jacquemard, A, Sourivong, Frédéric, Gendrault, Annie, Gendrault-Jacquemard, Gendrault-Jacquemard A, Chiapello H, Chiapello, H, Sourivong F, Bourgait I, Heuclin G, El Karoui M, El Karoui, Meriem, M., Heuclin, G, Petit, M-A, Bourgait, I, Heuclin, Gaëlle, Chiapello, Helene, Petit, Marie Agnès, Petit, Marie Agnes, M. A., Sourivong, F, Gendrault, Annie   +23 more
core   +1 more source

Antibiotic Resistance in Bacterial Pathogens

Antibiotics, 2023
The increasing number of infections caused by antibiotic-resistant bacterial pathogens over the last few decades has become a critical global health problem, the scale of which has led to it being named a “silent pandemic” [...]
openaire   +3 more sources

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

The entomopathogenic bacterial endosymbionts Xenorhabdus and Photorhabdus: convergent lifestyles from divergent genomes [PDF]

, 2011
Members of the genus Xenorhabdus are entomopathogenic bacteria that associate with nematodes. The nematode-bacteria pair infects and kills insects, with both partners contributing to insect pathogenesis and the bacteria providing nutrition to the ...
Givaudan, Alain, Karina C. Krasomil-Osterfeld, Goldman, Barry S., Youngjin Park, Brian C. Tjaden, Latreille Phil, Kimberly N Cowles, Carolyn M Lipke, Slominski Kathryn, Jennifer J. Knack, Menard, Megan L., Jewell, Kelsea A., Slominski, Kathryn, Karina C Krasomil-Osterfeld, Bosong Xiang, Kelsea A Jewell, Park Youngjin, Carolyn M. Lipke, Norton, Stacie, Archna Bhasin, Darby Renneckar Sugar, Sugar, Darby Renneckar, Nydia Morales-Soto, Miller Nancy M., Latreille, Phil, Andersen Aaron W., Barry S. Goldman, Lipke, Carolyn M., Barbara A. Qurollo, Kukor, Ryan, Martens Eric C., Brachmann, Alexander O., Welch Roy D., Qurollo, Barbara A., Jewell Kelsea A., Barbazuk, Brad, Jennifer J Knack, Slater, Steven C., Holly Snyder, van der Hoeven, Ransome, Anne Lanois, John M. Chaston, John M Chaston, Xiang, Bosong, Alain Givaudan, Lu, Xiaojun, Chaston, John M., Knack, Jennifer J., Ogier, Jean-Claude, Drace Kevin, Renyi Liu, Dongjin Park, Suen, Garret, Andersen, Aaron W., Park, Dongjin, Kimberly N. Cowles, Nancy K. Leimgruber, Zoé Rouy, Krasomil-Osterfeld, Karina C., Roy D Welch, Darby Creg, Claudine Médigue, Xiang Bosong, Tran, Erin E. Herbert, Erin E Herbert Tran, Park Dongjin, Lu Xiaojun, Park, Youngjin, Jean-Claude Ogier, Roy D. Welch, Morales-Soto, Nydia, Steven C. Slater, Kevin Drace, Médigue, Claudine, de Léon, Limaris, Helge B. Bode, Xiaojun Lu, Leimgruber Nancy K., Edna Bode, Brad Barbazuk, Nancy M. Miller, Megan L. Menard, Welch, Roy D., Synder, Holly, Eric C Martens, Liu, Renyi, Barry S Goldman, Brad Goodner, Orchard Samantha S., Steven C Slater, Cowles Kimberly N., Rouy Zoé, Zijin Du, Forst Steven, Ransome van der Hoeven, Erin E. Herbert Tran, Bode, Edna, Suen Garret, Chaston John M., Liu Renyi, Gregory R. Richards, Knack Jennifer J., Wheeler, Cathy, Pradeep R Marri, Snyder, Holly, Samantha S Orchard, Drace, Kevin, Marri Pradeep R., Brian C Tjaden, Brachmann Alexander O., Marri, Pradeep R., Limaris de Léon, Goldman Barry S., Gaudriault Sophie, Garret Suen, Slominski Brad, Gaudriault, Sophie, Sugar Darby Renneckar, Charles E. Cowles, Forst, Steven, Sophie Gaudriault, Goodrich-Blair, Heidi, Kathryn Slominski, Lipke Carolyn M., Heidi Goodrich-Blair, Gaudriault, Sophie, S., Cathy Wheeler, Charles E Cowles, Martens, Eric C., Sarah L Tucker, Givaudan Alain, Goodrich-Blair Heidi, Richards, Gregory R., Gregory R Richards, Aaron W Andersen, Miller, Nancy M., Phil Latreille, Ryan Kukor, Qurollo Barbara A., Barbazuk Brad, Tucker Sarah L., Cowles Charles E., Cowles, Kimberly N., Barbara A Qurollo, Lanois Anne, Snyder Holly, Darby, Creg, Léon, Limaris de, Bhasin Archna, Pradeep R. Marri, Leimgruber, Nancy K., Bhasin, Archna, Nancy M Miller, Brad Slominski, Bode, Helge Björn, Cowles, Charles E., Bode Edna, Slominski, Brad, Tjaden, Brian C., Kukor Ryan, Stacie Norton, Alexander O. Brachmann, Rouy, Zoé, Slater Steven C., Eric C. Martens, Lanois, Anne, Steven Forst, Hoeven, Ransome van der, Bode Helge B., Creg Darby, Aaron W. Andersen, Médigue Claudine, van der Hoeven Ransome, Alexander O Brachmann, Nancy K Leimgruber, Krasomil-Osterfeld Karina C., Menard Megan L., Kelsea A. Jewell, Sarah L. Tucker, Renneckar Sugar, Darby, Wheeler Cathy, Goodner, Brad, Morales-Soto Nydia, Goodner Brad, Bode, Helge B., Megan L Menard, Richards Gregory R., Norton Stacie, Helge B Bode, Du, Zijin, Orchard, Samantha S., de Léon Limaris, Tucker, Sarah L., Brachmann, Alexander Oliver, Du Zijin, Herbert Tran Erin E., Ogier Jean-Claude, Samantha S. Orchard, Tjaden Brian C.   +198 more
core   +2 more sources

Detection of Pathogens by a Novel User-Developed Broad-Range BR 16S PCR rRNA Polymerase Chain Reaction/Gene Sequencing Assay: Multiyear Experience in a Large Canadian Healthcare Zone

Microorganisms
Between 2015 and 2022, we evaluated a novel broad-range (BR) 16S PCR rDNA PCR/Sanger sequencing assay to improve diagnosis of invasive infections in culture-negative specimens.
Thomas Griener, Barbara Chow, Deirdre Church   +2 more
doaj   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source