Results 121 to 130 of about 7,915,148 (365)

Quantifying the benefit of a proteome reserve in fluctuating environments. [PDF]

, 2017
The overexpression of proteins is a major burden for fast-growing bacteria. Paradoxically, recent characterization of the proteome of Escherichia coli found many proteins expressed in excess of what appears to be optimal for exponential growth.
Erickson, David W, Gerland, Ulrich, Hwa, Terence, Mori, Matteo, Schink, Severin   +4 more
core   +3 more sources

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Comparison of bacterial intracellular and secreted proteins produced in milk versus medium for Escherichia coli by proteomic analysis

Journal of Dairy Science
: The growth and reproduction of microorganisms are dependent on nutrient supply. Here, milk and Luria-Bertani (LB) media were used as nutrition sources for Escherichia coli, and the changes in bacterial and secretory proteins at 3 time points (3, 9, and
Qiyue Sun, Yanxin Li, Hongning Jiang, Qijing Du, Jun Wang, Rongbo Fan, Rongwei Han, Yongxin Yang   +7 more
doaj   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Extractable Bacterial Surface Proteins in Probiotic–Host Interaction

Frontiers in Microbiology, 2018
Some Gram-positive bacteria, including probiotic ones, are covered with an external proteinaceous layer called a surface-layer. Described as a paracrystalline layer and formed by the self-assembly of a surface-layer-protein (Slp), this optional structure
Fillipe L. R. do Carmo, Fillipe L. R. do Carmo, Houem Rabah, Houem Rabah, Rodrigo D. De Oliveira Carvalho, Floriane Gaucher, Floriane Gaucher, Barbara F. Cordeiro, Sara H. da Silva, Yves Le Loir, Vasco Azevedo, Gwénaël Jan   +11 more
doaj   +1 more source

The Landscape of Realized Homologous Recombination in Pathogenic Bacteria [PDF]

, 2015
Recombination enhances the adaptive potential of organisms by allowing genetic variants to be tested on multiple genomic backgrounds. Its distribution in the genome can provide insight into the evolutionary forces that underlie traits, such as the ...
Didelot, X, Falush, D, Jolley, KA, Kobayashi, I, Maiden, MCJ, Sheppard, SK, Yahara, K   +6 more
core   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Apocytochrome c [PDF]

, 1990
The cytochrome c import pathway differs markedly from the general route taken by the majority of other imported proteins, which is characterized by the import involvement of namely, surface receptors, the general insertion protein (GIP), contact sites ...
Berkout, Böhni, Chen, Cheng, Chirico, Daldal, Deshaies, Deshaies, Drygas, Dumont, Dumont, Eilers, Enosawa, Gabellini, Gabellini, Gasser, Hartl, Hartl, Hawlitschek, Hennig, Hennig, Hennig, Horwich, Horwich, Hurt, Hurt, Jordi, Korb, Lewis, Matsuura, McAda, Meyer, Nargang, Nicholson, Nicholson, Nicholson, Nicholson, Pelham, Pfaller, Pfaller, Pfanner, Pfanner, Pfanner, Pfanner, Pollock, Randall, Rietveld, Rietveld, Rietveld, Rietveld, Rietveld, Rothman, Römisch, Sadler, Schleyer, Schleyer, Schwaiger, Smith, Stewart, Stuart, Stuart, Söllner, Teintze, Welch, Zimmermann, Zimmermann, Zitomer, Zwizinski, Zwizinski   +68 more
core   +1 more source

Bacterial surface proteins and vaccines [PDF]

F1000 Biology Reports, 2010
Surface-associated proteins play a key role in bacterial physiology and pathogenesis and are the major targets for vaccine development. Recent advances in defining the proteins associated with, and protruding out of, bacterial cells to a high level of accuracy are substantially contributing to accelerating the process of vaccine target identification ...
openaire   +2 more sources

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source