Results 81 to 90 of about 7,915,148 (365)

Cytosolic redox components regulate protein homeostasis via additional localisation in the mitochondrial intermembrane space [PDF]

, 2017
Oxidative protein folding is confined to the bacterial periplasm, endoplasmic reticulum and the mitochondrial intermembrane space. Maintaining a redox balance requires the presence of reductive pathways.
Cardenas-Rodriguez, Mauricio, Tokatlidis, Konstantinos   +1 more
core   +1 more source

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

The Chlamydia trachomatis Type III Secretion Chaperone Slc1 Engages Multiple Early Effectors, Including TepP, a Tyrosine-phosphorylated Protein Required for the Recruitment of CrkI-II to Nascent Inclusions and Innate Immune Signaling [PDF]

, 2014
Chlamydia trachomatis, the causative agent of trachoma and sexually transmitted infections, employs a type III secretion (T3S) system to deliver effector proteins into host epithelial cells to establish a replicative vacuole.
Bastidas, Robert J., Carpenter, Victoria K., Chen, Yi-Shan, Plano, Gregory V., Richards, Kristian L., Saka, Hector Alex, Valdivia, Raphael H.   +6 more
core   +3 more sources

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Dancing to Another Tune—Adhesive Moonlighting Proteins in Bacteria

Biology, 2014
Biological moonlighting refers to proteins which express more than one function. Moonlighting proteins occur in pathogenic and commensal as well as in Gram-positive and Gram-negative bacteria.
Veera Kainulainen, Timo K. Korhonen
doaj   +1 more source

A Review of the Bacterial Phosphoproteomes of Beneficial Microbes

Microorganisms, 2023
The number and variety of protein post-translational modifications (PTMs) found and characterized in bacteria over the past ten years have increased dramatically. Compared to eukaryotic proteins, most post-translational protein changes in bacteria affect
Sooa Lim
doaj   +1 more source

Microbial differences between dental plaque and historic dental calculus are related to oral biofilm maturation stage [PDF]

, 2019
Dental calculus, calcified oral plaque biofilm, contains microbial and host biomolecules that can be used to study historic microbiome communities and host responses.
CJ Adler, C Warinner, C Warinner, S Buckley, IM Velsko, J Hendy, ID Mandel, C Warinner, C Walker, V Zijnge, P Ramberg, D Belstrøm, PE Kolenbrander, WG Wade, SS Socransky, IM Velsko, SC Holt, M Umeda, BH Mullally, JW Lee, IM Velsko, LM Shaddox, AW Aruni, KL Cross, L Albayrak, S Yost, VM Barnes, JL Ebersole, S Yost, P Jorth, A Basic, RR Jersie-Christensen, T Imamura, LS Weyrich, AA Ribeiro, EL Gross, A Simón-Soro, Zachary D. Moye, O Manor, SM Dabdoub, D Belstrøm, RC Page, S Hillson, A Ogden, S Brooks, JL Buckberry, D Ferembach, CO Lovejoy, TW Phenice, LAF Frantz, P Skoglund, P Skoglund, M. Meyer, A Ginolhac, H Jónsson, A Peltzer, M Schubert, H Li, H Li, M Meyer, D Knights, N Segata, DT Truong, DH Parks, DH Parks, M Bastian, R Overbeek, DH Huson, MC Chambers, FE Dewhirst   +69 more
core   +4 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Domain organization of long autotransporter signal sequences [PDF]

, 2010
Bacterial autotransporters represent a diverse family of proteins that autonomously translocate across the inner membrane of Gram-negative bacteria via the Sec complex and across the outer bacterial membrane.
Hiß, Jan Alexander, Schneider, Gisbert (Prof. Dr.)   +1 more
core   +1 more source

Adaptive response of neonatal sepsis-derived Group B Streptococcus to bilirubin [PDF]

, 2018
This work was funded by the Neonatal Unit Endowment Fund, Aberdeen Maternity Hospital. RH is funded by a career researcher fellowship from NHS Research Scotland. SG was funded by the MRC Flagship PhD programme.
Berry, Susan, Collie-Duguid, Elaina S. R., De Paiva Alves, Eduardo, El-Omar, Emad, Gibson, Sophie, Goddard, Mark, Hansen, Richard, Hold, Georgina L., Karcher, Anne Marie, MacLaren, Andrew, Munro, Mike   +10 more
core   +4 more sources