Results 201 to 210 of about 194,060 (257)
Advanced Science, EarlyView.Orally administered, pH‐responsive Co‐SAN exerts dual functions: in the alkaline intestinal milieu, it scavenges reactive oxygen species (ROS) and suppresses the PI3K/AKT pathway and NETs formation, thus providing radioprotection; whereas in the acidic tumor microenvironment, it generates ROS and alleviates hypoxia, thereby enhancing radiosensitization.
Shengqi Yin +13 more
wiley +1 more source
Advanced Science, EarlyView.IMM‐H018, a dual IDO1/NE inhibitor, demonstrates potent therapeutic efficacy in sepsis by simultaneously targeting excessive inflammation and immune dysfunction. It prevents both primary and secondary sepsis through anti‐inflammatory, immune‐restoring, and renoprotective mechanisms, reducing organ damage, improving immune homeostasis, preserving kidney
Yi Zhou +11 more
wiley +1 more source
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Toxins: Bacterial and Marine Toxins
Clinics in Laboratory Medicine, 2006The term toxin refers in a specific way to a toxic substance of biologic origin; that is, a true toxin is a poison produced by a living organism. The purpose of this article is to review some of the most potentially dangerous toxins of concern today. Mechanisms of action, routes of exposure, diagnostic tools, and treatment recommendations are addressed.
Matthew, Salzman +2 more
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Vaccine, 1985
A rebirth of interest and activity in vaccine development has occurred in recent years which is probably due to the persistence of threat to health by infectious diseases, as well as technological advances which have made possible new approaches to solve old problems.
F, Dorner, J L, McDonel
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A rebirth of interest and activity in vaccine development has occurred in recent years which is probably due to the persistence of threat to health by infectious diseases, as well as technological advances which have made possible new approaches to solve old problems.
F, Dorner, J L, McDonel
openaire +2 more sources
Bacterial Toxins and Diarrhoea
Clinics in Gastroenterology, 1986Bacteria and their toxins are responsible for an enormous burden of diarrhoeal disease. Knowledge about the toxins and their mechanisms of action is limited. Thus, although considerable information is available about the mechanism of action of cholera toxin and a small number of heat-stable enterotoxins, information on the role and action of many ...
K J, Moriarty, L A, Turnberg
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Angewandte Chemie International Edition, 2012
AbstractProtein toxins constitute the main virulence factors of several species of bacteria and have proven to be attractive targets for drug development. Lead candidates that target bacterial toxins range from small molecules to polymeric binders, and act at each of the multiple steps in the process of toxin‐mediated pathogenicity.
Ivarsson ME, Leroux JC, Castagner B
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AbstractProtein toxins constitute the main virulence factors of several species of bacteria and have proven to be attractive targets for drug development. Lead candidates that target bacterial toxins range from small molecules to polymeric binders, and act at each of the multiple steps in the process of toxin‐mediated pathogenicity.
Ivarsson ME, Leroux JC, Castagner B
openaire +3 more sources
Nature Reviews Molecular Cell Biology, 2001
Pathogenic bacteria and higher eukaryotes have spent a long time together, leading to a precise understanding of one another's way of functioning. Through rapid evolution, bacteria have engineered increasingly sophisticated weapons to hit exactly where it hurts, interfering with fundamental host functions.
G, Schiavo, F G, van der Goot
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Pathogenic bacteria and higher eukaryotes have spent a long time together, leading to a precise understanding of one another's way of functioning. Through rapid evolution, bacteria have engineered increasingly sophisticated weapons to hit exactly where it hurts, interfering with fundamental host functions.
G, Schiavo, F G, van der Goot
openaire +2 more sources
Critical Reviews in Microbiology, 2004
Over the years it has been important for humans to control the populations of harmful insects and insecticides have been used for this purpose in agricultural and horticultural sectors. Synthetic insecticides, owing to their various side effects, have been widely replaced by biological insecticides. In this review we attempt to describe three bacterial
Abanti, Chattopadhyay +2 more
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Over the years it has been important for humans to control the populations of harmful insects and insecticides have been used for this purpose in agricultural and horticultural sectors. Synthetic insecticides, owing to their various side effects, have been widely replaced by biological insecticides. In this review we attempt to describe three bacterial
Abanti, Chattopadhyay +2 more
openaire +2 more sources
Bacterial Toxins as Immunomodulators
2009Bacterial toxins are the causative agent at pathology in a variety of diseases. Although not always the primary target of these toxins, many have been shown to have potent immunomodulatory effects, for example, inducing immune responses to co-administered antigens and suppressing activation of immune cells.
David S, Donaldson, Neil A, Williams
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The Hospital
In the globalizing world, food safety and food-borne pathogenic microorganisms are among the important public health problems. There are more than 250 known foodborne diseases and many different types of viruses, bacteria, parasites, toxins, metals and prions that cause these diseases.
Reyhan Gul Guven, Kemal Guven
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In the globalizing world, food safety and food-borne pathogenic microorganisms are among the important public health problems. There are more than 250 known foodborne diseases and many different types of viruses, bacteria, parasites, toxins, metals and prions that cause these diseases.
Reyhan Gul Guven, Kemal Guven
openaire +3 more sources