Association of Polygenic Risk Score and Bacterial Toxins at Screening Colonoscopy with Colorectal Cancer Progression: A Multicenter Case-Control Study. [PDF]
Toxins (Basel), 2021 Colorectal cancer (CRC) is a leading cause of cancer death worldwide, and its incidence is correlated with infections, chronic inflammation, diet, and genetic factors.
Piciocchi A +24 more
europepmc +2 more sources
Special Issue: Gram-Positive Bacterial Toxins [PDF]
Microorganisms, 2023 The Gram stain classifies most bacteria into one of two groups, Gram-negative or Gram-positive, based on the composition of their cell walls [...]
Shashi Sharma +2 more
doaj +2 more sources
Interferon-mediated reprogramming of membrane cholesterol to evade bacterial toxins. [PDF]
Nat Immunol, 2020 Plasma membranes of animal cells are enriched for cholesterol. Cholesterol-dependent cytolysins (CDCs) are pore-forming toxins secreted by bacteria that target membrane cholesterol for their effector function.
Zhou QD +19 more
europepmc +2 more sources
Bacterial toxins in musculoskeletal infections. [PDF]
J Orthop Res, 2021 Musculoskeletal infections (MSKIs) remain a major health burden in orthopaedics. Bacterial toxins are foundational to pathogenesis in MSKI, but poorly understood by the community of providers that care for patients with MSKI, inducing an international group of microbiologists, infectious diseases specialists, orthopaedic surgeons and biofilm scientists
Saeed K +17 more
europepmc +6 more sources
Evolutionary Features in the Structure and Function of Bacterial Toxins. [PDF]
Toxins (Basel), 2019 Toxins can function both as a harmful and therapeutic molecule, depending on their concentrations. The diversity in their function allows us to ask some very pertinent questions related to their origin and roles: (a) What makes them such effective ...
Kumar R +5 more
europepmc +2 more sources
Bacterial glycosyltransferase toxins [PDF]
Cellular Microbiology, 2015 Mono‐glycosylation of host proteins is a common mechanism by which bacterial protein toxins manipulate cellular functions of eukaryotic target host cells.
T. Jank, Y. Belyi, K. Aktories
semanticscholar +5 more sources
Autoproteolytic Activation of Bacterial Toxins [PDF]
Toxins, 2010 Protease domains within toxins typically act as the primary effector domain within target cells. By contrast, the primary function of the cysteine protease domain (CPD) in Multifunctional Autoprocessing RTX-like (MARTX) and Clostridium sp.
Aimee Shen
doaj +4 more sources
Investigation of the adsorption capacity of the enterosorbent Enterosgel for a range of bacterial toxins, bile acids and pharmaceutical drugs. [PDF]
Sci Rep, 2019 Oral intestinal adsorbents (enterosorbents) are orally administered materials which pass through the gut where they bind (adsorb) various substances. The enterosorbent Enterosgel (Polymethylsiloxane polyhdrate) is recommended as a symptomatic treatment ...
Howell CA +3 more
europepmc +2 more sources
Bacterial toxins: Offensive, defensive, or something else altogether? [PDF]
PLoS Pathog, 2017 The secretion of proteins that damage host tissue is well established as integral to the infectious processes of many bacterial pathogens. However, recent advances in our understanding of the activity of toxins suggest that the attributes we have ...
Rudkin JK +3 more
europepmc +2 more sources
Bacterial toxins as pathogen weapons against phagocytes
Frontiers in Microbiology, 2016 Bacterial toxins are virulence factors that manipulate host cell functions and take over the control of vital processes of living organisms to favour microbial infection.
Ana edo Vale +5 more
doaj +2 more sources