Interactions between Autophagy and Bacterial Toxins: Targets for Therapy? [PDF]
Toxins, 2015 Autophagy is a physiological process involved in defense mechanisms for clearing intracellular bacteria. The autophagic pathway is finely regulated and bacterial toxins interact with this process in a complex manner.
Jacques Mathieu
doaj +3 more sources
Bacterial glycosyltransferase toxins [PDF]
Cellular Microbiology, 2015 Mono-glycosylation of host proteins is a common mechanism by which bacterial protein toxins manipulate cellular functions of eukaryotic target host cells. Prototypic for this group of glycosyltransferase toxins are Clostridium difficile toxins A and B, which modify guanine nucleotide-binding proteins of the Rho family.
Jank, Thomas +2 more
openaire +5 more sources
Bacterial toxins as pathogen weapons against phagocytes
Frontiers in Microbiology, 2016 Bacterial toxins are virulence factors that manipulate host cell functions and take over the control of vital processes of living organisms to favour microbial infection.
Ana edo Vale +5 more
doaj +2 more sources
Evolution of insect innate immunity through domestication of bacterial toxins. [PDF]
Proc Natl Acad Sci U S A, 2023 Significance Several disease-causing bacteria produce toxins that damage host cells by triggering preprogrammed cell death. Two such bacterial toxins are called cytolethal distending toxin B and apoptosis-inducing protein of 56 kDa.
Verster KI +12 more
europepmc +2 more sources
New Strategies for Biocontrol of Bacterial Toxins and Virulence: Focusing on Quorum-Sensing Interference and Biofilm Inhibition. [PDF]
Toxins (Basel), 2023 The overuse of antibiotics and the emergence of multiple-antibiotic-resistant pathogens are becoming a serious threat to health security and the economy.
Zhang H, Zhang Z, Li J, Qin G.
europepmc +2 more sources
Advances in the Study of Bacterial Toxins, Their Roles and Mechanisms in Pathogenesis. [PDF]
Malays J Med Sci, 2022 Pathogenic bacteria use various mechanisms to cause infections in the host. Bacterial pathogens express a wide range of molecules. Bacterial toxins have a poisonous substance created and secreted at the extracellular or intracellular level, making these ...
Ghazaei C.
europepmc +2 more sources
Bacterial Toxins Active against Mosquitoes: Mode of Action and Resistance. [PDF]
Toxins (Basel), 2021 Larvicides based on the bacteria Bacillus thuringiensis svar. israelensis (Bti) and Lysinibacillus sphaericus are effective and environmentally safe compounds for the control of dipteran insects of medical importance.
Silva-Filha MHNL +7 more
europepmc +2 more sources
Use of Short-Chain Fatty Acids for the Recovery of the Intestinal Epithelial Barrier Affected by Bacterial Toxins. [PDF]
Front Physiol, 2021 Short-chain fatty acids (SCFAs) are carboxylic acids produced as a result of gut microbial anaerobic fermentation. They activate signaling cascades, acting as ligands of G-protein-coupled receptors, such as GPR41, GPR43, and GPR109A, that can modulate ...
Pérez-Reytor D +3 more
europepmc +2 more sources
Channel-Forming Bacterial Toxins in Biosensing and Macromolecule Delivery
Toxins, 2014 To intoxicate cells, pore-forming bacterial toxins are evolved to allow for the transmembrane traffic of different substrates, ranging from small inorganic ions to cell-specific polypeptides. Recent developments in single-channel electrical recordings,
Philip A. Gurnev +1 more
doaj +2 more sources
Association of Polygenic Risk Score and Bacterial Toxins at Screening Colonoscopy with Colorectal Cancer Progression: A Multicenter Case-Control Study. [PDF]
Toxins (Basel), 2021 Colorectal cancer (CRC) is a leading cause of cancer death worldwide, and its incidence is correlated with infections, chronic inflammation, diet, and genetic factors.
Piciocchi A +24 more
europepmc +2 more sources