Results 11 to 20 of about 1,820,370 (346)

Role of O-Acetylation in the Immunogenicity of Bacterial Polysaccharide Vaccines

Molecules, 2018
The incidence of infectious diseases caused by several bacterial pathogens such as Haemophilus influenzae type b, Streptococcus pneumoniae, and Neisseria meningitidis, has been dramatically reduced over the last 25 years through the use of glycoconjugate
Francesco Berti, Riccardo De Ricco, Rino Rappuoli   +2 more
doaj   +2 more sources

The neglected model validation of antimicrobial resistance transmission models – a systematic review [PDF]

Antimicrobial Resistance and Infection Control
Background In the fight against antimicrobial resistance, mathematical transmission models have been shown as a valuable tool to guide intervention strategies in public health.
Maja L. Brinch, Andrea Palladino, Jeroen Geurtsen, Thierry Van Effelterre, Lorenzo Argante, Michael J. McConnell, Lene Christiansen, Michelle A. Pihl, Natasja K. Lund, Tine Hald   +9 more
doaj   +2 more sources

Epitope-Based Vaccines: The Next Generation of Promising Vaccines Against Bacterial Infection [PDF]

Vaccines
The increasing resistance of bacteria to antibiotics has underscored the need for new drugs or vaccines to prevent bacterial infections. Reducing multidrug resistance is a key objective of the WHO’s One Health initiative.
Jing Li, Yan Ju, Min Jiang, Sha Li, Xiao-Yan Yang   +4 more
doaj   +2 more sources

Development in the Concept of Bacterial Polysaccharide Repeating Unit-Based Antibacterial Conjugate Vaccines.

ACS Infectious Diseases, 2023
The surface of cells is coated with a dense layer of glycans, known as the cell glycocalyx. The complex glycans in the glycocalyx are involved in various biological events, such as bacterial pathogenesis, protection of bacteria from environmental ...
Rajendra S Rohokale, Zhongwu Guo
semanticscholar   +1 more source

Combined effects of glycan chain length and linkage type on the immunogenicity of glycoconjugate vaccines

npj Vaccines, 2021
The development and use of antibacterial glycoconjugate vaccines have significantly reduced the occurrence of potentially fatal childhood and adult diseases such as bacteremia, bacterial meningitis, and pneumonia.
Chakkumkal Anish, Michel Beurret, Jan Poolman   +2 more
doaj   +1 more source

Clinical trial of tolerability, safety, and immunogenicity of the Russian influenza inactivated split vaccine Flu-m in children from 6 months to 9 years of age

Журнал инфектологии, 2023
Purpose: To study the reactogenicity, safety and immunogenicity of the Russian vaccine Flu-M in comparison with Vaxigrip vaccine for influenza prevention in children aged from 6 months to 9 years (phase III).Materials and Methods.
A. M. Korolyuk, L. A. Zazimko, V. N. Kraeva, Yu. A. Koromzin, E. A. Ruzanova, A. A. Ekimov, N. N. Savina, E. V. Ryskova, V. P. Trukhin   +8 more
doaj   +1 more source

Development and validation of a targeted LC-MS/MS quantitation method to monitor cell culture expression of tetanus neurotoxin during vaccine production [PDF]

Talanta vol. 236 (2022): 122883, 2022
The tetanus neurotoxin (TeNT) is one of the most toxic proteins known to man, which prior to the use of the vaccine against the TeNT producing bacteria Clostridium tetani, resulted in a 20 % mortality rate upon infection. The clinical detrimental effects of tetanus have decreased immensely since the introduction of global vaccination programs, which ...
arxiv   +1 more source

Mechanistic Modeling of Mycobacterium tuberculosis Infection in Murine Models for Drug and Vaccine Efficacy Studies. [PDF]

, 2020
Tuberculosis (TB) drug, regimen, and vaccine development rely heavily on preclinical animal experiments, and quantification of bacterial and immune response dynamics is essential for understanding drug and vaccine efficacy.
Nuermberger, Eric L, Savic, Rada M, Soni, Heena, Strydom, Natasha, Tasneen, Rokeya, Tyagi, Sandeep, Zhang, Nan   +6 more
core   +1 more source

Chikungunya vaccines: advances in the development and prospects for marketing approval

Биопрепараты: Профилактика, диагностика, лечение, 2023
Chikungunya fever is an acute infectious disease caused by the mosquito-borne Chikungunya virus (CHIKV). In the last decades, cases of the disease have been reported in more than 100 countries; therefore, CHIKV presents a global public health problem ...
E. V. Otrasheuskaja, V. P. Trukhin, V. A. Merkulov, G. M. Ignatyev   +3 more
doaj   +1 more source

Bacterial Spores as Vaccine Vehicles [PDF]

Infection and Immunity, 2003
ABSTRACT For the first time, bacterial spores have been evaluated as vaccine vehicles. Bacillus subtilis spores displaying the tetanus toxin fragment C (TTFC) antigen were used for oral and intranasal immunization and were shown to generate mucosal and systemic responses in a murine model.
DUC L. H., HUYNH H. A., FAIRWEATHER N., RICCA, EZIO, CUTTING S. M.   +4 more
openaire   +3 more sources