Results 81 to 90 of about 1,820,370 (346)

A Low Gastric pH Mouse Model to Evaluate Live Attenuated Bacterial Vaccines

open access: yesPLoS ONE, 2014
The low pH of the stomach serves as a barrier to ingested microbes and must be overcome or bypassed when delivering live bacteria for vaccine or probiotic applications. Typically, the impact of stomach acidity on bacterial survival is evaluated in vitro,
K. Brenneman   +4 more
semanticscholar   +1 more source

The Promising Potential of Reverse Vaccinology-Based Next-Generation Vaccine Development over Conventional Vaccines against Antibiotic-Resistant Bacteria

open access: yesVaccines, 2023
The clinical use of antibiotics has led to the emergence of multidrug-resistant (MDR) bacteria, leading to the current antibiotic resistance crisis. To address this issue, next-generation vaccines are being developed to prevent antimicrobial resistance ...
Kanwal Khalid, C. Poh
semanticscholar   +1 more source

Innate immunity: ignored for decades, but not forgotten. [PDF]

open access: yes, 2012
The innate immune system must recognize and rapidly respond to microbial pathogens, providing a first line of host defense. This is accomplished through an array of pattern recognition receptors (PRRs) that reside in specific subcellular compartments and
Adam   +53 more
core   +1 more source

Understanding and Overcoming Immunotherapy Resistance in Skin Cancer: Mechanisms and Strategies

open access: yesAging and Cancer, EarlyView.
This narrative review explores the mechanisms driving immunotherapy resistance in skin cancer, including tumor microenvironment factors, genetic mutations, and immune evasion strategies. It highlights potential strategies to overcome resistance, offering insights for improving therapeutic outcomes and guiding future research in personalized ...
Shreya Singh Beniwal   +8 more
wiley   +1 more source

The Impact of Vaccination Behavior on Disease Spreading Based on Complex Networks [PDF]

open access: yesarXiv, 2021
Vaccination is an effective way to prevent and control the occurrence and epidemic of infectious diseases. However, many factors influence whether the residents decide to get vaccinated or not, such as the efficacy and side effects while individuals hope to obtain immunity through vaccination.
arxiv  

THE THERAPEUTIC USE OF BACTERIAL VACCINES [PDF]

open access: yesThe American Journal of the Medical Sciences, 1910
n ...
openaire   +3 more sources

Adjuvant Strategies for Lactic Acid Bacterial Mucosal Vaccines

open access: yesVaccines, 2019
Lactic acid bacteria (LAB) are Gram-positive, acid-tolerant bacteria that have long been used in food fermentation and are generally recognized as safe (GRAS).
A. Vilander, G. Dean
semanticscholar   +1 more source

Strategies to Design and Optimize Artificial Antigen‐Presenting Cells for T Cell Expansion in Cancer Immunotherapy

open access: yesAdvanced Functional Materials, EarlyView.
This review highlights recent advances in engineering artificial antigen‐presenting cells (aAPCs) as alternatives to dendritic cells for T cell expansion. Key design principles inspired by the immunological synapse are discussed, with emphasis on strategies for polyclonal and antigen‐specific T cell expansion.
Nguyen Thi Nguyen, Yu Seok Youn
wiley   +1 more source

A randomized phase 1/2a trial of ExPEC10V vaccine in adults with a history of UTI

open access: yesnpj Vaccines
The safety, reactogenicity, and immunogenicity of 3 doses of ExPEC10V (VAC52416), a vaccine candidate to prevent invasive Escherichia coli disease, were assessed in a phase 1/2a study (NCT03819049). In Cohort 1, ExPEC10V was well tolerated; the high dose
Carlos A. Fierro   +9 more
doaj   +1 more source

Home - About - Disclaimer - Privacy