Results 191 to 200 of about 434,771 (384)

Distinct Phage‐Encoded Enzymes for Substitution of Deoxythymidine by Deoxyuridine in Phage Genomes

Advanced Science, EarlyView.
Distinct enzymes including dCTP deaminases (Dcds), dTMP phosphatases (Dtms), and dTTP pyrophosphatases (Dtt) are found to be responsible for dU‐DNA biosynthesis in the phages PBS1, DSS3_VP1, and PhiR1‐37. Both PhiR1‐37‐derived and synthetic dU‐DNA are resistant to cleavage by restriction enzymes and Cas12a nuclease targeting dT‐containing sites.
Yating Li, Jason Tan, Yanqin Tu, Jingnan Wu, Zaifang Zhang, Yifeng Wei, Xinan Jiao, Yan Zhou   +7 more
wiley   +1 more source

Supramolecular Interactions Modulate RNA:DNA Folding Observed via Nanopore Sensing

Angewandte Chemie, EarlyView.
Solid‐state nanopores enable the detection of RNA species at the single‐molecule level. To rapidly and accurately identify barcoded RNAs as they translocate the pore, it is imperative to reduce analyte folding. Here, we demonstrate that RNA's supramolecular interactions with urea inhibit folding, increasing the number of readable barcodes while ...
Thieme T. Schmidt, Max K. Earle, Gerardo Patiño‐Guillén, Yunxuan Li, Raluca‐Elena Alexii, Jeremy J. Baumberg, Ulrich F. Keyser, Casey M. Platnich   +7 more
wiley   +2 more sources

BRIGHT Enables High‐SNR Live‐Cell Imaging of Non‐Repetitive Sequences via Bivalent Fluorescent Nanobody‐Mediated Cascade‐Dependent Illumination

Advanced Science, EarlyView.
BRIGHT is a newly developed live‐cell imaging system that integrates cascade amplification with background denoising through the bivalent binding capability and antigen‐dependent stability of a bivalent fluorescent nanobody targeting ALFA peptides.
Lei Feng, Tao Huang, Yanxi Han, Meng Tian, Duo Wang, Zilong Mei, Yu Ma, Yingshuo Ma, Jinming Li, Rui Zhang   +9 more
wiley   +1 more source

Effects of Clupein and of its Degradation Products on a Rhizobium Bacteriophage, on its Host Bacterium and on the Interaction between the two

, 1956
J. Kleczkowski, A. Kleczkowski
openalex   +1 more source

INACTIVATION OF BACTERIOPHAGES BY DECAY OF INCORPORATED RADIOACTIVE PHOSPHORUS [PDF]

, 1955
Gunther S. Stent, Clarence R. Fuerst
openalex   +1 more source

Three‐Segment Protein Labeling Using a Highly Efficient and Cysteine‐Less Split Intein Identified with Computational Prediction of Aggregation Properties

Angewandte Chemie, EarlyView.
Tandem protein trans‐splicing (PTS) assembles a protein from three segments. Expanding this technology to individually treat cysteines in each segment, for example, for chemical labeling using thiol bioconjugation, the authors identify a second, highly efficient cysteine‐less split intein.
Christoph Humberg, Jonas Kröger, Shmuel Pietrokovski, Henning D. Mootz   +3 more
wiley   +2 more sources

A bacteriophage T7 RNA polymerase/promoter system for controlled exclusive expression of specific genes.

Proceedings of the National Academy of Sciences of the United States of America, 1985
S. Tabor, C. Richardson
semanticscholar   +1 more source

Emerging Nanozyme Strategies for Precision Breast Cancer Treatment

Advanced Science, EarlyView.
Different types of nanozymes‐mediated chemotherapy, photothermal therapy, immunotherapy, and multiple combined therapies for the effective treatment of breast cancer. Abstract Breast cancer, the most common malignant tumor among women worldwide, poses a significant challenge to public health due to its high incidence and mortality rates.
Jian Zang, Zhaozhou Ren, Haibo Wang, Xing Yang, Yang Song, Jun Liao, Xiaoying Li   +6 more
wiley   +1 more source

Conformational Quenching in an Engineered Lipocalin Protein Achieves High Affinity Binding to the Toxin Colchicine

Angewandte Chemie, EarlyView.
Specific high affinity recognition of colchicine by an engineered anticalin involves loop dynamics and conformational selection Abstract The engineered lipocalin Colchicalin binds the clinically relevant plant toxin colchicine with picomolar affinity.
Mark J. Bostock, Christopher Kolloff, Elena Jerschke, Sam Asami, Arne Skerra, Simon Olsson, Michael Sattler   +6 more
wiley   +2 more sources

Fluorescence Guided Surgery in Gastric Cancer: What Do We Have and What Can We Do?

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background and Objective Fluorescence imaging has emerged as a valuable adjunct in gastric surgery, enhancing resection precision and oncologic outcomes. However, the use of indocyanine green (ICG) remains controversial due to uncertainties in efficacy and administration. A lack of standardized protocols persists.
Chun Zhuang, Han‐Kwang Yang
wiley   +1 more source