Results 201 to 210 of about 246,265 (316)

Large‐Scale Structural Dynamics in the Tail Fiber Modulate the Infective Transition of the T7 Bacteriophage

open access: yesSmall, EarlyView.
During host recognition, the fibers of T7 bacteriophages transition from a capsid bound state to an extended conformation, which requires some level of fiber flexibility. By using high‐speed atomic force microscopy, we show that the fibers have an internal molecular hinge and a torsionally compliant coiled‐coil region.
Luca Elizabet Kosik   +16 more
wiley   +1 more source

ICP1 bacteriophage treatment antagonizes colonization of the zebrafish larval intestine by <i>Vibrio cholerae</i>. [PDF]

open access: yesMicrobiol Spectr
Sidi Mabrouk A   +9 more
europepmc   +1 more source

Discriminating Between Living and Dead Bacteria With a Field‐Effect Transistor Based on Nano‐Channels

open access: yesSmall, EarlyView.
Bacterial viability is determined in a complex environment with a field‐effect biological transistor with a limit of detection of a single bacterium. Living, antibiotic‐treated, thermally denatured, and inhibited E. coli generate distinct electrical signatures, enabling label‐free single‐cell detection and providing new opportunities for rapid ...
Bar Chen   +17 more
wiley   +1 more source

Targeting the CD47–SIRPα phagocytic checkpoint in cancer: Biology, translational opportunities, and next‐generation therapeutic strategies

open access: yesSmart Molecules, EarlyView.
The CD47–SIRPα axis has emerged as a critical innate immune checkpoint that suppresses macrophage‐mediated phagocytosis through a canonical “don't eat me” signal and enables tumor immune evasion. We comprehensively summarize the structural and biological features of CD47 and the molecular mechanisms underlying CD47‐mediated regulation of phagocytosis ...
Ruimei Zhou   +4 more
wiley   +1 more source

Isolation and genomic characterization of a lytic bacteriophage against multidrug-resistant Proteus mirabilis. [PDF]

open access: yesAppl Microbiol Biotechnol
Kushwaha P   +10 more
europepmc   +1 more source

DOM: Dual Optical Mapping Integrating Sequence‐Specific Barcodes and A/T Density Profiles

open access: yesSmall Methods, EarlyView.
Dual Optical Mapping (DOM) combines sequence‐specific barcodes and an A/T profile to generate complementary genomic signatures along single DNA molecules. The integration of sparse and dense mapping information enables accurate and confident genome mapping, facilitating reliable localization of long DNA molecules in complex genomes, including the ...
Jaeyoung Bae   +10 more
wiley   +1 more source

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