Results 201 to 210 of about 434,771 (384)

Bismuth–Selenopeptides Combine Potent Bioactivity with Exceptional Kinetic Inertness

open access: yesAngewandte Chemie, EarlyView.
A major obstacle for bismuth peptides and proteins, in which Bi(III) is coordinated by three cysteine residues, is their kinetic lability when challenged with strong metal chelators. By simply replacing cysteines with selenocysteines, we significantly increased kinetic stability, extending the lifetime to several days.
Pritha Ghosh   +7 more
wiley   +2 more sources

Engineered RNA Devices for In Vivo Targeted Therapeutics via Advanced Delivery Systems

open access: yesAggregate, EarlyView.
Schematic illustration of engineered RNA devices for in vivo targeted therapeutics via advanced delivery systems. ABSTRACT Engineered RNA devices can identify disease‐specific markers and precisely regulate gene expression, which is of great significance to the development of precision medicine.
Wei Luo   +6 more
wiley   +1 more source

Reversible Sandwich‐Based Particle Nanoswitch for Continuous Protein Monitoring at Picomolar Concentrations with Automated Calibration

open access: yesAngewandte Chemie, EarlyView.
A reversible particle nanoswitch sensor enables continuous protein monitoring by forming transient sandwich complexes in the presence of analyte molecules. Site‐specific conjugations ensure optimal antibody fragment orientation. Demonstrated for lactoferrin, the sensor achieves picomolar sensitivity with ∼12 min time delay and continuous measurements ...
Claire M. S. Michielsen   +9 more
wiley   +2 more sources

Safety of bacteriophage therapy in severe Staphylococcus aureus infection

open access: yesNature Microbiology, 2020
Aleksandra Petrović Fabijan   +12 more
semanticscholar   +1 more source

Harnessing Large Language Models to Advance Microbiome Research: From Sequence Analysis to Clinical Applications

open access: yesAdvanced Intelligent Discovery, EarlyView.
Large language models are transforming microbiome research by enabling advanced sequence profiling, functional prediction, and association mining across complex datasets. They automate microbial classification and disease‐state recognition, improving cross‐study integration and clinical diagnostics.
Jieqi Xing   +4 more
wiley   +1 more source

A Bacteriophage for B. anthracis

open access: bronze, 1931
Philip B. Cowles
openalex   +1 more source

Peptide/Antibody–Drug Conjugates for Therapeutic Applications in Inflammatory Disease

open access: yesAdvanced NanoBiomed Research, EarlyView.
Peptide/antibody–drug conjugates (PADCs) combine ligand specificity and cleavable linkers to deliver drugs precisely to disease sites with minimal toxicity. While current approvals focus on oncology, this review examines their untapped potential in inflammatory diseases, detailing mechanisms of targeted delivery and highlighting advances that position ...
Yeongji Jang   +5 more
wiley   +1 more source

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