Results 251 to 260 of about 434,771 (384)

Gankyrin‐Protein Interactions in GI Cancers: A Novel Target of New Therapeutics

open access: yesChronic Diseases and Translational Medicine, EarlyView.
ABSTRACT Gankyrin (PSMD10) is a 25 kDa oncogenic protein and regulatory subunit of the 26S proteasome, characterized by a sevenfold ankyrin repeat domain. Gankyrin is overexpressed in various malignancies, particularly gastrointestinal (GI) cancers. Gankyrin contributes to tumorigenesis by modulating key signaling pathways and engaging in oncogenic ...
Shuang Li   +4 more
wiley   +1 more source

Bacteriophage typing ofstaphylococcus aureus [PDF]

open access: bronze, 1952
R. E. O. Williams, Joan E. Rippon
openalex   +1 more source

Chemical Methods for Peptide and Protein Backbone Cleavage

open access: yesChemistryEurope, EarlyView.
Protein cleavage plays essential roles in biology and is powerful for protein manipulation and functionalization as well as in recombinant expression and purification. Here, the historical background and most recent examples of chemical methods for protein and peptide backbone cleavage are discussed (part of the figure was generated in BioRender).
Miguel Angel Alena‐Rodriguez   +1 more
wiley   +1 more source

Beware of host immune responses towards bacteriophages potentially impacting phage therapy. [PDF]

open access: yesVet Res
Démoulins T   +5 more
europepmc   +1 more source

Drug Discovery Applications of Nitroso (Hetero)Arene Derivatives

open access: yesChemPlusChem, EarlyView.
Nitroso (hetero)aromatic compounds are bioactive molecules with antiviral, anticancer, neuroprotective, and antimicrobial properties. This review highlights their mechanisms of action—oxidative stress, DNA damage, and enzyme inhibition—alongside synthesis, structure–activity relationships, and toxicity challenges, offering insight into their ...
Silvia Roscales, Aurelio G. Csáky
wiley   +1 more source

Pharmacomicrobiomics

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Oral medications encounter gut commensal microbes that participate directly and indirectly in drug effects through metabolism, interactions with drug metabolites, or production of substrates that compete with drugs for drug‐metabolizing enzymes, consequently influencing drug pharmacokinetics.
Naomi Gronich   +11 more
wiley   +1 more source

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