Antibacterial Efficacy of Two Commercially Available Bacteriophage Formulations, Staphylococcal Bacteriophage and PYO Bacteriophage, Against Methicillin-Resistant Staphylococcus aureus: Prevention and Eradication of Biofilm Formation and Control of a Systemic Infection of Galleria mellonella Larvae [PDF]
, 2020 Sessile bacteria growing on surfaces are more resistant to standard antibiotics than their planktonic counterpart. Due to their antimicrobial properties, bacteriophages have re-emerged as a promising approach to treat bacterial biofilm-associated ...
Di Luca, Mariagrazia +4 more
core +1 more source
Cross-reactivity between tumor MHC class I–restricted antigens and an enterococcal bacteriophage
Science, 2020 Phages and cancer immunity Gut bacteria are involved in the education of T cell immune responses, and the intestinal ecosystem influences anticancer immunity. Fluckiger et al. report microbial antigens that might cross-react with antigens associated with
A. Fluckiger +51 more
semanticscholar +1 more source
Mechanisms and clinical importance of bacteriophage resistance
FEMS Microbiology Reviews, 2021 We are in the midst of a golden age of uncovering defense systems against bacteriophages. Apart from the fundamental interest in these defense systems, and revolutionary applications that have been derived from them (e.g.
Julia E. Egido +4 more
semanticscholar +1 more source
Bacillus Phage vB_BtS_B83 Previously Designated as a Plasmid May Represent a New Siphoviridae Genus
Viruses, 2019 The Bacillus cereus group of bacteria includes, inter alia, the species known to be associated with human diseases and food poisoning. Here, we describe the Bacillus phage vB_BtS_B83 (abbreviated as B83) infecting the species of this group.
Emma G. Piligrimova +3 more
doaj +1 more source
Genome signatures, self-organizing maps and higher order phylogenies: a parametric analysis [PDF]
, 2007 Genome signatures are data vectors derived from the compositional statistics of DNA. The self-organizing map (SOM) is a neural network method for the conceptualisation of relationships within complex data, such as genome signatures.
Gatherer, Derek
core +4 more sources
Do Anti-Phage Antibodies Persist after Phage Therapy? A Preliminary Report
Antibiotics, 2022 Phages are immunogenic and may evoke an immune response following their administration. Consequently, patients undergoing phage therapy (PT) produce phage-neutralizing serum antibodies.
Marzanna Łusiak-Szelachowska +5 more
doaj +1 more source
Bacteriophages and their genomes [PDF]
Current Opinion in Virology, 2011 Bacteriophages occupy a unique position in biology, representing an absolute majority of all organisms in the biosphere. Because their genomes are relatively small, elucidating the genetic diversity of the phage population, deciphering their origins, and identifying the evolutionary mechanisms that shape the population would seem readily feasible.
Roger W. Hendrix, Graham F. Hatfull
openaire +3 more sources
Phage Prevalence in the Human Urinary Tract—Current Knowledge and Therapeutic Implications
Microorganisms, 2020 Recent metagenomic analyses imply an immense abundance of phages in the human body. Samples collected from different sites (lungs, skin, oral cavity, intestines, ascitic fluid, and urine) reveal a generally greater number of phage particles than that of ...
Maciej Żaczek +3 more
doaj +1 more source
Comparative genomics of Shiga toxin encoding bacteriophages [PDF]
, 2012 Background Stx bacteriophages are responsible for driving the dissemination of Stx toxin genes (stx) across their bacterial host range. Lysogens carrying Stx phages can cause severe, lifethreatening disease and Stx toxin is an integral virulence factor.
Allison, Heather +6 more
core +2 more sources
Viruses, 2018 A potential concern with bacteriophage (phage) therapeutics is a host-versus-phage response in which the immune system may neutralize or destroy phage particles and thus impair therapeutic efficacy, or a strong inflammatory response to repeated phage ...
Helen R. Freyberger +4 more
doaj +1 more source