Results 61 to 70 of about 298,256 (336)

The Appearance of Antiphage Antibodies in Sera of Patients Treated with Phages

Antibiotics
Background: Bacteriophages are neutralized by the sera of patients undergoing phage therapy (PT), particularly during local or concomitant local and oral phage administration in bone infections, soft tissue infections, or upper respiratory tract ...
Marzanna Łusiak-Szelachowska, Beata Weber-Dąbrowska, Maciej Żaczek, Ryszard Międzybrodzki, Andrzej Górski   +4 more
doaj   +1 more source

vB_BcM_Sam46 and vB_BcM_Sam112, members of a new bacteriophage genus with unusual small terminase structure

Scientific Reports, 2021
One of the serious public health concerns is food contaminated with pathogens and their vital activity products such as toxins. Bacillus cereus group of bacteria includes well-known pathogenic species such as B. anthracis, B. cereus sensu stricto (ss), B.
Olesya A. Kazantseva, Emma G. Piligrimova, Andrey M. Shadrin   +2 more
doaj   +1 more source

Comparative susceptibility of mosquito populations in North Queensland, Australia to oral infection with dengue virus. [PDF]

, 2014
Dengue is the most prevalent arthropod-borne virus, with at least 40% of the world's population at risk of infection each year. In Australia, dengue is not endemic, but viremic travelers trigger outbreaks involving hundreds of cases.
Anderson, Andrew F. van den Hurk, Armstrong, Armstrong, Beebe, Beebe, Bennett, Bosio, Chevillon, Elizabeth A. McGraw, Endersby, Failloux, Forrester, Francesca D. Frentiu, Frentiu, Gubler, Gubler, Gubler, Guzman, Halstead, Halstead, Hanna, Holmes, Holmes, Huber, Kien, Knox, Kyle, Lambrechts, Lambrechts, Moreira, Neff, Nigel W. Beebe, Parameswaran, Paupy, Rosen, Ross, Scott L. O'Neill, Tat Siong Ng, Thomas Walker, Van Den Hurk, Vasilakis, Vazeille-Falcoz, Warrilow, Xi, Ye, Yixin H. Ye, Yoon   +47 more
core   +2 more sources

Identification of amino acids essential for angulin‐1/3 binding of the tricellular tight junction binder, angubindin‐1

FEBS Open Bio, EarlyView.
Angubindin‐1 binds angulin‐1/‐3 at tricellular tight junctions, enhancing intestinal macromolecule permeation. Alanine scanning identified six essential residues (L562, L598, E638, V640, Y643, and K644) of angubindin‐1 critical for binding to angulin‐1/‐3 and permeation‐enhancing activity, providing insights for the development of targeted noninvasive ...
Taiki Kuzu, Yumi Iwashita, Keisuke Tachibana, Itsuki Nishino, Yuki Niwa, Atsuko Uyeda, Kazuki Matsuo, Masahiro Nagahama, Masuo Kondoh   +8 more
wiley   +1 more source

Macrophage-induced reduction of bacteriophage density limits the efficacy of in vivo pulmonary phage therapy

Nature Communications
The rise of antimicrobial resistance leads to renewed interest in evaluating phage therapy. In murine models highly effective treatment of acute pneumonia caused by Pseudomonas aeruginosa relies on the synergistic antibacterial activity of bacteriophages
Sophia Zborowsky, Jérémy Seurat, Quentin Balacheff, Solène Ecomard, Céline Mulet, Chau Nguyen Ngoc Minh, Marie Titécat, Emma Evrard, Rogelio A. Rodriguez-Gonzalez, Jacopo Marchi, Joshua S. Weitz, Laurent Debarbieux   +11 more
doaj   +1 more source

Propionibacterium acnes bacteriophages display limited genetic diversity and broad killing activity against bacterial skin isolates. [PDF]

, 2012
UnlabelledInvestigation of the human microbiome has revealed diverse and complex microbial communities at distinct anatomic sites. The microbiome of the human sebaceous follicle provides a tractable model in which to study its dominant bacterial ...
Bowman, Charles, Cokus, Shawn, Fitz-Gibbon, Sorel, Hatfull, Graham F, Hayes, Clarmyra, Inkeles, Megan, Jacobs-Sera, Deborah, Kim, Jenny, Loncaric, Anya, Marinelli, Laura J, Miller, Jeff F, Modlin, Robert L, Pellegrini, Matteo, Russell, Daniel A   +13 more
core   +2 more sources

Targeting RAGE with Nanobodies for Molecular Imaging of Cancers and Alzheimer's Disease

Advanced Biology, EarlyView.
RAGE‐specific nanobodies were isolated via phage display and characterized by ELISA, cell ELISA, and SPR. In vivo imaging in renal carcinoma and Alzheimer's disease mouse models demonstrated that NbF8, the highest‐affinity clone, selectively targeted RAGE‐overexpressing tumors and brain tissues, highlighting its potential as a molecular imaging agent ...
Guangfeng Liang, Fujing Wang, Wei Xiong, Guangwei Shi, Junling Yuan, Yang Li, Hongyan Zhang, Yanmei Xing, Shan Jin, Kongjun Yang, Zhongliang Dai, Jichao Sun, Zhijie Li, Jianhong Wang   +13 more
wiley   +1 more source

Characterization of bacteriophage vB_KleM_KB2 possessing high control ability to pathogenic Klebsiella pneumoniae

Scientific Reports, 2023
Klebsiella pneumoniae is a widespread pathogen of several human diseases. The emergence of multidrug-resistant K. pneumoniae makes the treatment of these diseases a significant challenge.
Qin Peng, Zimeng Ma, Qing Han, Fangfang Xiang, Lushuang Wang, Yibin Zhang, Yuting Zhao, Jianing Li, Yaxin Xian, Yihui Yuan   +9 more
doaj   +1 more source

Investigation of Salmonella Phage–Bacteria Infection Profiles: Network Structure Reveals a Gradient of Target-Range from Generalist to Specialist Phage Clones in Nested Subsets

Viruses, 2021
Bacteriophages that lyse Salmonella enterica are potential tools to target and control Salmonella infections. Investigating the host range of Salmonella phages is a key to understand their impact on bacterial ecology, coevolution and inform their use in ...
Khatuna Makalatia, Elene Kakabadze, Nata Bakuradze, Nino Grdzelishvili, Ben Stamp, Ezra Herman, Avraam Tapinos, Aidan Coffey, David Lee, Nikolaos G. Papadopoulos, David L. Robertson, Nina Chanishvili, Spyridon Megremis   +12 more
doaj   +1 more source

Chromosomal DNA deletion confers phage resistance to Pseudomonas aeruginosa. [PDF]

, 2014
Bacteria develop a broad range of phage resistance mechanisms, such as prevention of phage adsorption and CRISPR/Cas system, to survive phage predation.
He, Xuesong, Hu, Fuquan, Jin, Xiaolin, Le, Shuai, Li, Ming, Lu, Shuguang, Lux, Renate, Rao, Xiancai, Shi, Wenyuan, Tan, Yinling, Wang, Jing, Wu, Nicholas C, Yao, Xinyue, Zhao, Yan   +13 more
core   +1 more source