Results 61 to 70 of about 373,043 (334)

What Are the Potential Benefits of Using Bacteriophages in Periodontal Therapy?

Antibiotics, 2022
Periodontitis, which may result in tooth loss, constitutes both a serious medical and social problem. This pathology, if not treated, can contribute to the development of, among others, pancreatic cancer, cardiovascular diseases or Alzheimer’s disease ...
Jan Kowalski, Renata Górska, Martyna Cieślik, Andrzej Górski, Ewa Jończyk-Matysiak   +4 more
doaj   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

The Appearance of Antiphage Antibodies in Sera of Patients Treated with Phages

Antibiotics
Background: Bacteriophages are neutralized by the sera of patients undergoing phage therapy (PT), particularly during local or concomitant local and oral phage administration in bone infections, soft tissue infections, or upper respiratory tract ...
Marzanna Łusiak-Szelachowska, Beata Weber-Dąbrowska, Maciej Żaczek, Ryszard Międzybrodzki, Andrzej Górski   +4 more
doaj   +1 more source

Identification of amino acids essential for angulin‐1/3 binding of the tricellular tight junction binder, angubindin‐1

FEBS Open Bio, EarlyView.
Angubindin‐1 binds angulin‐1/‐3 at tricellular tight junctions, enhancing intestinal macromolecule permeation. Alanine scanning identified six essential residues (L562, L598, E638, V640, Y643, and K644) of angubindin‐1 critical for binding to angulin‐1/‐3 and permeation‐enhancing activity, providing insights for the development of targeted noninvasive ...
Taiki Kuzu, Yumi Iwashita, Keisuke Tachibana, Itsuki Nishino, Yuki Niwa, Atsuko Uyeda, Kazuki Matsuo, Masahiro Nagahama, Masuo Kondoh   +8 more
wiley   +1 more source

Putative plasmid prophages of Bacillus cereus sensu lato may hold the key to undiscovered phage diversity

Scientific Reports, 2021
Bacteriophages are bacterial viruses and the most abundant biological entities on Earth. Temperate bacteriophages can form prophages stably maintained in the host population: they either integrate into the host genome or replicate as plasmids in the host
Emma G. Piligrimova, Olesya A. Kazantseva, Andrey N. Kazantsev, Nikita A. Nikulin, Anna V. Skorynina, Olga N. Koposova, Andrey M. Shadrin   +6 more
doaj   +1 more source

Investigation of Salmonella Phage–Bacteria Infection Profiles: Network Structure Reveals a Gradient of Target-Range from Generalist to Specialist Phage Clones in Nested Subsets

Viruses, 2021
Bacteriophages that lyse Salmonella enterica are potential tools to target and control Salmonella infections. Investigating the host range of Salmonella phages is a key to understand their impact on bacterial ecology, coevolution and inform their use in ...
Khatuna Makalatia, Elene Kakabadze, Nata Bakuradze, Nino Grdzelishvili, Ben Stamp, Ezra Herman, Avraam Tapinos, Aidan Coffey, David Lee, Nikolaos G. Papadopoulos, David L. Robertson, Nina Chanishvili, Spyridon Megremis   +12 more
doaj   +1 more source

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

FEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli, Enrico Landi, Francesco Maiurano, Irene Paris, Rosanna Papa, Marco Artini, Laura Selan, Stefano Borocci, Francesco Buonocore, Esther Imperlini   +9 more
wiley   +1 more source

Macrophage-induced reduction of bacteriophage density limits the efficacy of in vivo pulmonary phage therapy

Nature Communications
The rise of antimicrobial resistance leads to renewed interest in evaluating phage therapy. In murine models highly effective treatment of acute pneumonia caused by Pseudomonas aeruginosa relies on the synergistic antibacterial activity of bacteriophages
Sophia Zborowsky, Jérémy Seurat, Quentin Balacheff, Solène Ecomard, Céline Mulet, Chau Nguyen Ngoc Minh, Marie Titécat, Emma Evrard, Rogelio A. Rodriguez-Gonzalez, Jacopo Marchi, Joshua S. Weitz, Laurent Debarbieux   +11 more
doaj   +1 more source

vB_BcM_Sam46 and vB_BcM_Sam112, members of a new bacteriophage genus with unusual small terminase structure

Scientific Reports, 2021
One of the serious public health concerns is food contaminated with pathogens and their vital activity products such as toxins. Bacillus cereus group of bacteria includes well-known pathogenic species such as B. anthracis, B. cereus sensu stricto (ss), B.
Olesya A. Kazantseva, Emma G. Piligrimova, Andrey M. Shadrin   +2 more
doaj   +1 more source

Bacteriolytic Potential of Enterococcus Phage iF6 Isolated from “Sextaphag^®” Therapeutic Phage Cocktail and Properties of Its Endolysins, Gp82 and Gp84

Viruses, 2023
The number of infections caused by antibiotic-resistant strains of bacteria is growing by the year. The pathogenic bacterial species Enterococcus faecalis and Enterococcus faecium are among the high priority candidate targets for the development of new ...
Rustam M. Buzikov, Olesya A. Kazantseva, Emma G. Piligrimova, Natalya A. Ryabova, Andrey M. Shadrin   +4 more
doaj   +1 more source