Results 71 to 80 of about 434,771 (384)

Detection of intermediates and kinetic control during assembly of bacteriophage P22 procapsid [PDF]

, 2008
Bacteriophage P22 serves as a model for the assembly and maturation of other icosahedral double-stranded DNA viruses. P22 coat and scaffolding proteins assemble in vitro into an icosahedral procapsid, which then expands during DNA packaging (maturation).
Abendon, Canady, Casjens, Ceres, Earnshaw, Endres, Falkner, Feigin, Fowler, Galisteo, Golub, Guinier, Hendrix, Hiro Tsuruta, Jiang, Kang, Kenneth H. French, Kihara, King, Lanman, Paatero, Paatero, Parent, Parent, Parent, Parker, Parker, Parker, Parker, Parker, Peter E. Prevelige, Prasad, Prevelige, Prevelige, Prevelige, Quinn, Reddy, Roman Tuma, Sakalian, Stockley, Stray, Sun, Svergun, Thuman-Commike, Thuman-Commike, Thuman-Commike, Tuma, Wang, Wang, Wyckoff, Zhang, Zlotnick, Zlotnick, Zlotnick   +53 more
core   +1 more source

Bacteriophage Applications for Food Production and Processing

Viruses, 2018
Foodborne illnesses remain a major cause of hospitalization and death worldwide despite many advances in food sanitation techniques and pathogen surveillance.
Zachary D. Moye, Joelle E. Woolston, A. Sulakvelidze   +2 more
semanticscholar   +1 more source

Eradication of a multi-drug resistant, carbapenemase-producing Klebsiella pneumoniae isolate following oral and intra-rectal therapy with a custom-made, lytic bacteriophage preparation.

Clinical Infectious Diseases, 2020
In July 2017, a patient presented colonization with a multi-drug resistant, carbapenemase (KPC-3)-producing Klebsiella pneumoniae isolate. A custom-made, lytic bacteriophage preparation was administered to the patient in December 2017, with subsequent ...
M. Corbellino, N. Kieffer, M. Kutateladze, N. Balarjishvili, Lika Leshkasheli, L. Askilashvili, G. Tsertsvadze, S. Rimoldi, D. Nizharadze, N. Hoyle, L. Nadareishvili, S. Antinori, C. Pagani, D. Scorza, Ai Ling Loredana Romanò, S. Ardizzone, P. Danelli, M. Gismondo, M. Galli, P. Nordmann, L. Poirel   +20 more
semanticscholar   +1 more source

Bacteriophage as an Alternative to Antibiotics Promotes Growth Performance by Regulating Intestinal Inflammation, Intestinal Barrier Function and Gut Microbiota in Weaned Piglets

Frontiers in Veterinary Science, 2021
This study aimed to investigate the effects of dietary bacteriophage supplementation on growth performance, intestinal morphology, barrier function, and intestinal microbiota of weaned piglets fed antibiotic-free diet.
Yongxiang Zeng, Zirui Wang, T. Zou, Jun Chen, Guanhong Li, L. Zheng, Shuo Li, J. You   +7 more
semanticscholar   +1 more source

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

Macrophage-induced reduction of bacteriophage density limits the efficacy of in vivo pulmonary phage therapy

Nature Communications
The rise of antimicrobial resistance leads to renewed interest in evaluating phage therapy. In murine models highly effective treatment of acute pneumonia caused by Pseudomonas aeruginosa relies on the synergistic antibacterial activity of bacteriophages
Sophia Zborowsky, Jérémy Seurat, Quentin Balacheff, Solène Ecomard, Céline Mulet, Chau Nguyen Ngoc Minh, Marie Titécat, Emma Evrard, Rogelio A. Rodriguez-Gonzalez, Jacopo Marchi, Joshua S. Weitz, Laurent Debarbieux   +11 more
doaj   +1 more source

The Appearance of Antiphage Antibodies in Sera of Patients Treated with Phages

Antibiotics
Background: Bacteriophages are neutralized by the sera of patients undergoing phage therapy (PT), particularly during local or concomitant local and oral phage administration in bone infections, soft tissue infections, or upper respiratory tract ...
Marzanna Łusiak-Szelachowska, Beata Weber-Dąbrowska, Maciej Żaczek, Ryszard Międzybrodzki, Andrzej Górski   +4 more
doaj   +1 more source

vB_BcM_Sam46 and vB_BcM_Sam112, members of a new bacteriophage genus with unusual small terminase structure

Scientific Reports, 2021
One of the serious public health concerns is food contaminated with pathogens and their vital activity products such as toxins. Bacillus cereus group of bacteria includes well-known pathogenic species such as B. anthracis, B. cereus sensu stricto (ss), B.
Olesya A. Kazantseva, Emma G. Piligrimova, Andrey M. Shadrin   +2 more
doaj   +1 more source

Investigation of Salmonella Phage–Bacteria Infection Profiles: Network Structure Reveals a Gradient of Target-Range from Generalist to Specialist Phage Clones in Nested Subsets

Viruses, 2021
Bacteriophages that lyse Salmonella enterica are potential tools to target and control Salmonella infections. Investigating the host range of Salmonella phages is a key to understand their impact on bacterial ecology, coevolution and inform their use in ...
Khatuna Makalatia, Elene Kakabadze, Nata Bakuradze, Nino Grdzelishvili, Ben Stamp, Ezra Herman, Avraam Tapinos, Aidan Coffey, David Lee, Nikolaos G. Papadopoulos, David L. Robertson, Nina Chanishvili, Spyridon Megremis   +12 more
doaj   +1 more source

Integrative omics analysis of Pseudomonas aeruginosa virus PA5oct highlights the molecular complexity of jumbo phages [PDF]

, 2020
Pseudomonas virus vB_PaeM_PA5oct is proposed as a model jumbo bacteriophage to investigate phage-bacteria interactions and is a candidate for phage therapy applications.
Blasdel, Bob G., Briers, Yves, Danis‐Wlodarczyk, Katarzyna, Drulis‐Kawa, Zuzanna, Jang, Ho Bin, Lavigne, Rob, Lood, Cédric, Noben, Jean‐Paul, Noort, Vera, Vandenheuvel, Dieter   +9 more
core   +1 more source