Results 91 to 100 of about 259,182 (233)
Chemical Syntheses of 3′ and 5′ Phosphorylated Oligonucleotides: An Overview
European Journal of Organic Chemistry, EarlyView.This review provides an overview of the various chemical methods employed in the synthesis of oligonucleotides bearing a phosphate group at their 3′ or 5′ end. Notably, it presents modified phosphoramidites and supports developed for this purpose. Oligonucleotides (ON) with a phosphate monoester group at their 3′ or 5′ end have applications in many ...
Rémy Lartia
wiley +1 more source
Nature CommunicationsA major challenge in evolutionary biology is explaining how populations navigate rugged fitness landscapes without getting trapped on local optima.
Michael B. Doud +5 more
doaj +1 more source
Journal of Chemical Technology &Biotechnology, EarlyView.Abstract BACKGROUND Hospital premises generate wastewater containing a wide spectrum of contaminants, such as pharmaceutically active compounds (PhACs), antibiotic resistance genes (ARGs) and pathogenic microorganisms, whilst plenty of them are classified under the antibiotic resistant bacteria (ΑRΒ) category.
Andreas Kaliakatsos +11 more
wiley +1 more source
Optimal first-passage time in gene regulatory networks
, 2014 The inherent probabilistic nature of the biochemical reactions, and low copy number of species can lead to stochasticity in gene expression across identical cells.
Ghusinga, Khem Raj, Singh, Abhyudai
core +1 more source
Trapped in the web: network architectures spread coevolution and shape adaptation
Oikos, EarlyView.Adaptation is critical for biodiversity to persist under global change. Within ecological communities, species often face tradeoffs between adapting to shifting abiotic conditions and navigating the complex selective pressures imposed by interaction networks.
Alexandre Fuster‐ Calvo +5 more
wiley +1 more source
Frontiers in MicrobiologyThe CRISPR-Cas system, an adaptive immune mechanism in prokaryotes against bacteriophages, has been developed into a versatile tool for recognizing and cleaving target nucleic acid sequences.
Chan Kyeong Lee +3 more
doaj +1 more source
Phase variation and the Hin protein: in vivo activity measurements, protein overproduction, and purification [PDF]
, 1984 The alternate expression of the Salmonella flagellin genes H1 and H2 is controlled by the orientation of a 995-base-pair invertible segment of DNA located at the 5' end of the H2 gene.
Bruist, Michael F., Simon, Melvin I.
core
Rapid identification of E. coli bacteriophages using mass spectrometry [PDF]
, 2017 Objective: The current increasing interest in the application of mass spectrometry, in particular MALDI-TOF MS, to identification of bacteria and fungi calls for a need to utilise this technology for identification of other infectious agents such as ...
Pantoja Munoz, Leonardo +4 more
core +1 more source
New map of bacteriophage lambda DNA [PDF]
Journal of Virology, 1980 A map of bacteriophage lambda was constructed, including accurate positions for all 41 cut sites made by 12 different restriction enzymes. Over 100 fragments from single, multiple, and partial enzyme digestions were measured versus standards that were calibrated with respect to DNA molecules of known sequence.
D L, Daniels, J R, de Wet, F R, Blattner
openaire +2 more sources
Small, EarlyView.A new nanoparticle‐based biomarker panel is described that can differentiate pancreatic cancer from benign pancreatic disease with a high level of performance. This was enabled by microelectrode array recovery technology that used dielectrophoresis (DEP) to quickly and efficiently recover the nanoparticles from patient plasma samples, followed by on ...
Anna Malakian +23 more
wiley +1 more source