Results 81 to 90 of about 259,182 (233)
Angewandte Chemie, Volume 138, Issue 17, 20 April 2026.This study explores the origins of life by linking prebiotic chemistry, the emergence of information‐carrying molecules such as RNA and proteins, and philosophical questions about consciousness. The study emphasizes the role of molecular evolution in the Central Dogma and provides insights into the chemical origins of biology and the basis of life's ...
Harald Schwalbe +5 more
wiley +2 more sources
Natural biased coin encoded in the genome determines cell strategy. [PDF]
PLoS ONE, 2014 Decision making at a cellular level determines different fates for isogenic cells. However, it is not yet clear how rational decisions are encoded in the genome, how they are transmitted to their offspring, and whether they evolve and become optimized ...
Faezeh Dorri +6 more
doaj +1 more source
Genetically Programmed Control of Overflow Metabolism
Biotechnology and Bioengineering, EarlyView.ABSTRACT Overflow metabolism is a highly undesirable phenomenon that occurs in virtually all cell factories. Although several schemes have been applied to avoid overflow metabolism, this problem remains far from being solved. In this study, a genetic sensor for detecting overflow metabolism was designed, and its substrate specificity and reversibility ...
Lærke M. Jensen +3 more
wiley +1 more source
Commensal E. coli Stx2 lysogens produce high levels of phages after spontaneous prophage induction
Frontiers in Cellular and Infection Microbiology, 2015 Enterohemorrhagic E. coli (EHEC) is a food-borne pathogen that causes disease ranging from uncomplicated diarrhea to life-threatening hemolytic uremic syndrome (HUS) and nervous system complications.
Hildegunn eIversen +4 more
doaj +1 more source
mBio, 2022 Bacterial cells and their associated plasmids and bacteriophages encode numerous small proteins of unknown function. One example, the 73-amino-acid protein TraR, is encoded by the transfer operon of the conjugative F plasmid of Escherichia coli.
Saumya Gopalkrishnan +7 more
doaj +1 more source
Biotechnology Progress, EarlyView.Abstract The growing demand for cost‐efficient and flexible biomanufacturing has increased interest in process‐intensified downstream platforms. This study evaluates an intensified monoclonal antibody (mAb) purification sequence, where two unit operations traditionally performed in batch mode—Protein A capture and low pH virus inactivation (VI)—are ...
Mario Grünberg +8 more
wiley +1 more source
Molecular Systems Biology, 2012 Viral infection depends on a complex interplay between host and viral factors. Here, we link host susceptibility to viral infection to a network encompassing sulfur metabolism, tRNA modification, competitive binding, and programmed ribosomal ...
Nathaniel D Maynard +3 more
doaj +1 more source
Stochastic Cell Fate and Longevity of Offspring
Cell Journal, 2017 Objective: Cellular decision-making is a key process in which cells with similar genetic and environmental background make dissimilar decisions. This stochastic process, which happens in prokaryotic and eukaryotic cells including stem cells, causes ...
Faezeh Dorri +2 more
doaj +1 more source
Chemistry – A European Journal, EarlyView.The introduction outlines the review scope. Microbial cell factories as living drugs cover host–gut microbiota, bacteria, yeast, and other microbial systems, with comparative host advantages. Engineering strategies include synthetic circuits, quorum sensing, and memory.
Cemile Elif Özçelik +3 more
wiley +1 more source
Binding effects in multivalent Gibbs-Donnan equilibrium [PDF]
, 2005 The classical Gibbs-Donnan equilibrium describes excess osmotic pressure associated with confined colloidal charges embedded in an electrolyte solution.
A Evilevitch +5 more
core +4 more sources