Results 101 to 110 of about 259,182 (233)

The NMR structure of the Ea22 lysogenic developmental protein from lambda bacteriophage

Scientific Reports
The ea22 gene resides in a relatively uncharacterized region of the lambda bacteriophage genome between the exo and xis genes and is among the earliest genes transcribed upon infection.
Cameron Goddard, Bożena Nejman-Faleńczyk, Logan W. Donaldson   +2 more
doaj   +1 more source

An Escherichia coli Phosphotransferase System Modulates Methylglyoxal Resistance by Regulating Intracellular Potassium

Molecular Microbiology, EarlyView.
Escherichia coli can survive methylglyoxal stress by modulating phosphorylation of a regulatory phosphotransferase system, which, in turn, regulates the activity of a potassium/proton antiporter. The constitutive potassium importer Trk also contributes to intracellular potassium levels.
Sara Alexander, Mark Goulian
wiley   +1 more source

Advances in large DNA fragment assembly for microbial cell factory engineering

Quantitative Biology, Volume 14, Issue 3, September 2026.
Abstract The efficient, rapid, and reliable assembly of DNA fragments is essential for advancing metabolic engineering and synthetic biology. With the rapid advancement of DNA synthesis and assembly technologies, the scale of DNA assembly has expanded from single genes to metabolic pathways and even genomes.
Yu Zhang, Wenqian Liu, Dongyuan Cheng, Jiazhang Lian, Xian Fu, Yue Shen   +5 more
wiley   +1 more source

Beta protein of bacteriophage lambda promotes renaturation of DNA.

Journal of Biological Chemistry, 1981
The protein encoded by the red beta gene of bacteriophage lambda was found to promote reannealing of complementary single strands of DNA. Reannealing activity was optimal at pH 6.0 and required a divalent cation.
E. Kmiec, W. Holloman
semanticscholar   +1 more source

Enzymatic synthesis of bioactive quinolones and (thio)coumarins by fungal type III polyketide synthases

The FEBS Journal, Volume 293, Issue 9, Page 2673-2691, May 2026.
Quinolones are valuable scaffolds for drug discovery but are rare in nature. Here, we show that two fungal enzymes, AthePKS and FerePKS, can generate 2‐quinolones and two additional heteroaromatic scaffolds. Using AthePKS, we designed an artificial enzymatic cascade towards an antimicrobial quinolone from a simple precursor and implemented it in E ...
Nika Sokolova, Angelina Osipyan, Lili Zhang, Matthew R. Groves, Sandy Schmidt, Kristina Haslinger   +5 more
wiley   +1 more source

Bacterial Virus Lambda Gpd-Fusions to Cathelicidins, α- and β-Defensins, and Disease-Specific Epitopes Evaluated for Antimicrobial Toxicity and Ability to Support Phage Display

Viruses, 2019
We showed that antimicrobial polypeptides, when translated as gene fusions to the bacteriophage lambda capsid decoration protein gpD, formed highly toxic molecules within E.
Sidney Hayes
doaj   +1 more source

The Deletion of the Bre1 Gene in Aspergillus nidulans Impairs Mitotic Growth, Meiosis, and DNA Damage Repair

, 2013
Bre1 is a homotetrameric E3 ubiquitin-protein ligase that heterodimerizes with Rad6, an E2 ubiquitin-conjugating enzyme, in order to ubiquitinate lysine 123 in Aspergillus nidulans.
James, Steven W., Sitton, Andrea J.
core  

The NMR structure of the Orf63 lytic developmental protein from lambda bacteriophage

Scientific Reports
The orf63 gene resides in a region of the lambda bacteriophage genome between the exo and xis genes and is among the earliest genes transcribed during infection.
Naushaba Khan, Tavawn Graham, Katarzyna Franciszkiewicz, Sylwia Bloch, Bożena Nejman-Faleńczyk, Alicja Wegrzyn, Logan W. Donaldson   +6 more
doaj   +1 more source

Identification of a panel of tumor-associated antigens from breast carcinoma cell lines, solid tumors and testis cDNA libraries displayed on lambda phage

BMC Cancer, 2004
Background Tumor-associated antigens recognized by humoral effectors of the immune system are a very attractive target for human cancer diagnostics and therapy. Recent advances in molecular techniques have led to molecular definition of immunogenic tumor
Cianfriglia Maurizio, Lugini Antonio, De Pasquale Ceratti Adolfo, Dupuis Maria, Barca Stefano, Beghetto Elisa, Monteriù Giorgia, Pucci Andrea, Vaccaro Paola, Pavoni Emiliano, Cortesi Enrico, Felici Franco, Minenkova Olga   +12 more
doaj   +1 more source

ICP0 antagonizes ICP4-dependent silencing of the herpes simplex virus ICP0 gene.

PLoS ONE, 2010
ICP0 is a regulatory protein that plays a critical role in the replication-latency balance of herpes simplex virus (HSV). Absence of ICP0 renders HSV prone to establish quiescent infections, and thus cellular repressor(s) are believed to silence HSV mRNA
Mingyu Liu, Brandon Rakowski, Edward Gershburg, Carla M Weisend, Olivier Lucas, Edward E Schmidt, William P Halford   +6 more
doaj   +1 more source