Results 111 to 120 of about 44,922 (302)

Preclinical Assessment of Bacteriophage Therapy against Experimental Acinetobacter baumannii Lung Infection [PDF]

, 2021
Sandra-Maria Wienhold, Markus C. Brack, Geraldine Nouailles, Krishnamoorthy Gopinath, Imke H. E. Korf, C. Seitz, Sarah Wienecke, Kristina Dietert, Corinne Gurtner, Olivia Kershaw, Achim D. Gruber, Anton Roß, Holger Ziehr, Manfred Rohde, Jens Neudecker, Jasmin Lienau, Norbert Suttorp, Stefan Hippenstiel, Andreas C. Hocke, Christine H. Rohde, Martin Witzenrath   +20 more
openalex   +1 more source

Performance of large virus removal filters during AAV processing: Influence of flux and process disruptions

Biotechnology Progress, EarlyView.
Abstract As adeno‐associated viral vectors (AAV) continue to advance through the clinical pipeline, effective downstream purification strategies must be developed to ensure bulk drug purity and safety. AAV are produced within mammalian cells, bringing forth risks associated with viral contamination.
Akshay S. Chaubal, Asingsa W. Arachchige, Annabelle J. Zahn, S. Ranil Wickramasinghe, Xianghong Qian, Andrew L. Zydney   +5 more
wiley   +1 more source

Phage Therapy in Bacterial Infections Treatment: One Hundred Years After the Discovery of Bacteriophages [PDF]

, 2016
Agata Anna Cisek, Iwona Dąbrowska, Karolina P. Gregorczyk-Zboroch, Zbigniew Wyżewski   +3 more
openalex   +1 more source

Mini‐Hairpin DNA: Extraordinarily Stable Structure and Its Applications

Chemistry – A European Journal, EarlyView.
Mini‐hairpin DNA fragments containing GCGAAGC and GCGAAAGC form exceptionally stable hairpin‐like structures, with only two G−C pairs and one sheared G−A pair, remaining undenatured in 7 M urea and resisting nuclease digestion. These mini‐hairpin sequences frequently appear in replication and transcription origins, influence DNA sequencing fidelity ...
Michiko Kimoto, Ichiro Hirao
wiley   +1 more source

Investigating the phenotypic alterations associated with hypermucoviscous hypervirulent Klebsiella pneumoniae during phage resistance development

BMC Microbiology
Phage therapy has been explored and used compassionately in the post-antibiotic era, though phage resistance might pose a serious challenge. The advent of hypervirulent and hypermucoviscous traits in Klebsiella pneumoniae limits therapeutic choices. This
Ramya Juliet, Ramesh Nachimuthu
doaj   +1 more source

Advances in Double‐Stranded DNA Targeting Technologies

Exploration, EarlyView.
Double‐stranded DNA (dsDNA) plays a crucial role in genetic information storage and disease management, but its inherent stability limits access to internal bases. To overcome this challenge, various high‐specificity molecular targeting technologies have been developed to destabilize the DNA structure.
Zuhao Shen, Yiqun Liu, Yingjie Hao, Yifan Bo, Xiaochuan Dai, Shihui Wang, Tian Xia, Xin Su, Huiyu Liu   +8 more
wiley   +1 more source

Bioengineered Isoflavone–Probiotic Functional Foods for Sustainable Modulation of Metabolic and Reproductive Health in PCOS

Food Bioengineering, EarlyView.
Synergistic isoflavone‐probiotic action modulated metabolic, microbial and ovarian pathway ABSTRACT Polycystic ovary syndrome (PCOS) is a prevalent metabolic–endocrine disorder characterized by insulin resistance, hyperandrogenism, chronic inflammation, oxidative stress, and ovarian dysfunction, with growing evidence implicating gut microbiota ...
Jeyavelkumaran Renukadevi, Panneerselvam Sneha, Dhanapal Saravanan Mridula, Keerthivasan Nimithasree, Valliappan Sanjay   +4 more
wiley   +1 more source

Rapid Isolation of Bacteriophages: Steps Towards Phage Therapy

, 2019
Idah Sithole‐Niang, Shamiso Muchayi, Anna Mashonganyika   +2 more
openalex   +1 more source

Beyond a Conduit: The Evolution of Functional Biliary Stents From Active Intervention to Enabling Platforms

iNew Medicine, EarlyView.
This review traces the evolution of functional biliary stents, outlining the paradigm shift from “active intervention” strategies that target stent failure to next‐generation “enabling platforms.” These platforms leverage biodegradable materials, 3D/4D printing, and smart sensors to achieve personalized, regenerative, and theranostic solutions ...
Muhan Li, Xu Liu, Xin Ye, Zhixia Dong, Xinjian Wan   +4 more
wiley   +1 more source

Successful systemic phage therapy for implant-associated MRSA spondylodiscitis

International Journal of Infectious Diseases
Objectives: To describe the first experience with systemic bacteriophage therapy in a patient with chronic vertebral osteomyelitis caused by methicillin-resistant Staphylococcus aureus (MRSA) and limited antibiotic treatment options. Methods: We report a
Simona Arientová, Ondřej Beran, Tomáš Belšan, Michal Holub   +3 more
doaj   +1 more source