Results 101 to 110 of about 48,920 (278)

Mesoporous Catalytic‐Adsorptive Nanoregulator Orchestrates Biofilm eDNA/LPS Disassembly and TLR9/TLR4 Immune Reprogramming to Resolve Diabetic Foot Infections

Advanced Science, EarlyView.
Chronic diabetic wounds are hindered by a “dual trap” of biofilm resistance and hyperinflammation. A mesoporous catalytic‐adsorptive nano‐regulator is developed to dismantle this barrier through simultaneous eDNA degradation and LPS sequestration. By silencing TLR4/9‐mediated signaling, the platform clears resilient pathogens and reprograms the immune ...
Junfeng Song, Yang Song, Xirui Huang, Xingjin Li, Lifei Gao, Yixiang Wang, Tianbao Zhu, Xiaomin Li, Shuai Wang, Tiancong Zhao, Dongyuan Zhao   +10 more
wiley   +1 more source

Bacterial infectiogy, what role for phage therapy?

, 2007
The role of Bacteriophage ...
CAPPARELLI, ROSANNA
core  

Harnessing Large Language Models to Advance Microbiome Research: From Sequence Analysis to Clinical Applications

Advanced Intelligent Discovery, EarlyView.
Large language models are transforming microbiome research by enabling advanced sequence profiling, functional prediction, and association mining across complex datasets. They automate microbial classification and disease‐state recognition, improving cross‐study integration and clinical diagnostics.
Jieqi Xing, He Wang, Yangyang Sun, Xiaoquan Su, Shunyao Wu   +4 more
wiley   +1 more source

Bacteriophage therapy for the control of Vibrio harveyi in greenlip abalone (Haliotis laevigata) [PDF]

, 2017
Bacteriophage therapy has demonstrated promising results towards the control of bacterial infections within the aquaculture industry as an alternative therapy to antibiotics.
O'Dea, M., Elliott, L., Barton, M., Wang, Y., Li, X., Munro, J., Abraham, S.   +6 more
core   +1 more source

Salphage: Salvage bacteriophage therapy for a chronic Enterococcus faecalis prosthetic joint infection

, 2023
Chronic prosthetic joint infections are difficult to treat without conducting revision surgery because conventional antibiotics cannot eradicate bacteria that reside in biofilms.
Benjamin Chan, Aaron J. Johnson, James B. Doub   +2 more
core   +1 more source

Interspecies Biofilm Dynamics Among Staphylococci: Inflammatory Contributions to Chronic Rhinosinusitis

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Introduction Staphylococcus species are frequently isolated from the sinonasal niche of chronic rhinosinusitis (CRS) patients. While Staphylococcus aureus is often associated with recalcitrant CRS, Staphylococcus epidermidis and Staphylococcus lugdunensis are largely deemed commensal.
Sintayehu Ambachew, Mahnaz Ramezanpour, Clare M. Cooksley, Sholeh Feizi, Muhammed Awad, Kevin Aaron Fenix, Peter‐John Wormald, Alkis J. Psaltis, Sarah Vreugde   +8 more
wiley   +1 more source

Use of a Regression Model to Study Host-Genomic Determinants of Phage Susceptibility in MRSA

Antibiotics, 2018
Staphylococcus aureus is a major agent of nosocomial infections. Especially in methicillin-resistant strains, conventional treatment options are limited and expensive, which has fueled a growing interest in phage therapy approaches.
Henrike Zschach, Mette V. Larsen, Henrik Hasman, Henrik Westh, Morten Nielsen, Ryszard Międzybrodzki, Ewa Jończyk-Matysiak, Beata Weber-Dąbrowska, Andrzej Górski   +8 more
doaj   +1 more source

Retrospective, observational analysis of the first one hundred consecutive cases of personalized bacteriophage therapy of difficult-to-treat infections facilitated by a Belgian consortium

In contrast to the many reports of successful cases of personalized bacteriophage therapy, randomized controlled trials of non-personalized bacteriophage products did not bring the expected results.
Spiessens, An, de Jode, Mathieu, De Vos, Daniel>, Soentjens, Patrick, Rose, Thomas, Green, Sabrina, Chanishvili, Nina, Merabishvili, Maya, Glonti, Tea, Cochez, Christel, Van Nieuwenhuyse, Brieuc, Lood, Cédric, Wagemans, Jeroen, Onsea, Jolien, Pirnay, Jean-Paul, Vanden Berghe, Emily, Draye, Jean-Pierre, Ceyssens, Pieter-Jan, Bacteriophage Donors, Cornu, Olivier, Van der Linden, Dimitri, De Soir, Steven, Schrevens, Eddie, Verbeken, Gilbert, Griselain, Johann, Kutateladze, Mzia, Bacteriophage Therapy Providers, Chatzis, Olga, Djebara, Sarah, Steurs, Griet, Lavigne, Rob   +30 more
core   +1 more source

One‐step generation of heritable mitochondrial DNA multiplex‐engineered rats using DddA‐derived cytosine base editor

Animal Models and Experimental Medicine, EarlyView.
We established that mixed DdCBE microinjection is an efficient, heritable, and precise strategy for generating multiplex mtDNA mutant rats. This advancement significantly expands the utility of DdCBEs for mitochondrial disease modeling, providing a robust platform for exploring the pathogenic mechanisms of complex mtDNA mutations and developing ...
Xu Zhang, Keru Li, Lei Tan, Wei Chen, Shan Gao, Chenyang Liu, Shuo Pan, Jiayue He, Ning Liu, Gefan Wan, Wei Dong, Weining Kong, Bin Shen, Xiaolong Qi, Yuanwu Ma   +14 more
wiley   +1 more source

Dual Nature of Bacteriophages: Friends or Foes in Minimally Processed Food Products—A Comprehensive Review

Viruses
The increasing consumer demand for minimally processed foods (MPFs) has highlighted the need for innovative preservation methods that ensure both safety and quality.
Michał Wójcicki, Barbara Sokołowska, Andrzej Górski, Ewa Jończyk-Matysiak   +3 more
doaj   +1 more source