Results 81 to 90 of about 48,920 (278)

A Dual‐Functional Biohybrid Nanorobot to Synergistically Eradicate Biofilm and Degrade Antibiotic Resistance Genes

Advanced Science, EarlyView.
A biohybrid nanorobot integrating lytic bacteriophage N4 with Pd nanozymes is developed for targeted eradication of multidrug‐resistant E. coli biofilms. Synergistic bacterial lysis and ROS‐mediated oxidation enable simultaneous biofilm removal and antibiotic resistance genes degradation, maintaining high efficacy in complex wastewater environments ...
Junzheng Zhang, Tong Dou, Luokai Wang, Jingxian Yang, Wenrui Wang, Shuaitian Guo, Xiangyu Li, Xuefang Huang, Yunlei Xianyu, Dongsheng Wang   +9 more
wiley   +1 more source

Bacteriophage Therapy for Treating Infections: Hope or Hype?

, 2022
Bacteriophage therapy employs the use of viruses to kill bacteria and has been noted to confer reversal of antimicrobial resistance. It was proposed around the same time as antibiotic therapy for combatting infections but lost the race for becoming the ...
Nasa, Anurag
core  

Novel bacteriophage therapy for controlling metallo-beta-lactamase producing Pseudomonas aeruginosa infection in Catfish [PDF]

, 2013
Background: The bacteriophage therapy is an effective antimicrobial approach with potentially important applications in medicine and biotechnology which can be seen as an additional string in the bow.
Krishna Khairnar, Rajshree H Chandekar, Mahendra P Raut, Swapnil G Sanmukh, Khairnar, Krishna, Chandekar, Rajshree H, Waman N Paunikar, Sanmukh, Swapnil G, Paunikar, Waman N, Raut, Mahendra P   +9 more
core   +1 more source

DNA Nanoarray for Multiplexed RNA Detection With Single‐Molecule Readout

Advanced Science, EarlyView.
A carrier‐based DNA nanoarray integrates programmable nucleic acid hybridization with solid‐state nanopore readout for direct RNA detection at single‐molecule resolution. A ternary encoding system enables 27 carriers with 81 addressable sensing sites, allowing the simultaneous identification of targets spanning a wide size range, from short microRNAs ...
Yunxuan Li, Yesheng Wang, Chunmiao Yu, Siyu Hou, Elli Mylona, Plamena Naydenova, Jingyuan Zhao, Hong Yuan, Jingsong Duan, Hendrik F. P. Runge, Stephen Baker, Jinbo Zhu, Ulrich F. Keyser   +12 more
wiley   +1 more source

Bacteriophage therapy as an innovative strategy for the treatment of Periprosthetic Joint Infection: a systematic review. [PDF]

Int Orthop
International audienceAbstract Background Periprosthetic Joint Infection (PJI) following hip and knee arthroplasty is a catastrophic complication in orthopaedic surgery.
Yang S, Mukh AA, Abdelatif E, Schmidt A, Batailler C, Ferry T, Lustig S.   +6 more
europepmc   +2 more sources

Resistance Development to Bacteriophages Occurring during Bacteriophage Therapy [PDF]

Viruses, 2018
Bacteriophage (phage) therapy, i.e., the use of viruses that infect bacteria as antimicrobial agents, is a promising alternative to conventional antibiotics. Indeed, resistance to antibiotics has become a major public health problem after decades of extensive usage.
openaire   +5 more sources

Phage Therapy: Beyond Antibacterial Action

Frontiers in Medicine, 2018
Until recently, phages were considered as mere “bacteria eaters” with potential for use in combating antimicrobial resistance. The real value of phage therapy assessed according to the standards of evidence-based medicine awaits confirmation by clinical ...
Andrzej Górski, Andrzej Górski, Andrzej Górski, Ewa Jończyk-Matysiak, Ryszard Międzybrodzki, Ryszard Międzybrodzki, Ryszard Międzybrodzki, Beata Weber-Dąbrowska, Beata Weber-Dąbrowska, Marzanna Łusiak-Szelachowska, Natalia Bagińska, Jan Borysowski, Małgorzata B. Łobocka, Małgorzata B. Łobocka, Alicja Węgrzyn, Grzegorz Węgrzyn   +15 more
doaj   +1 more source

Successful Treatment of Staphylococcus aureus Prosthetic Joint Infection with Bacteriophage Therapy

, 2021
Successful joint replacement is a life-enhancing procedure with significant growth in the past decade. Prosthetic joint infection occurs rarely; it is a biofilm-based infection that is poorly responsive to antibiotic alone.
Bri’Anna Horne, Francis Gonzales, Joseph Fackler, Matthew Henry, Biswajit Biswas, Michael J. Brownstein, Claudia Ramirez-Sanchez, Saima Aslam, Maureen Buckley, Michael V. Deschenes, Robert T. Schooley   +10 more
core   +1 more source

Decoding the Mechanism of Action of a Parasite TGFβ Antagonist Inspires the Creation of Cell‐Type‐Specific TGFβ Modulators

Advanced Science, EarlyView.
The mammalian TGFβ interacts with ubiquitously expressed TGFBR1 and TGFBR2, and current TGFβ‐targeting agents are non‐cell‐selective. The cooperative interaction of the modular parasite TGFβ antagonist with multiple host (co‐)receptors empowers the design of TGM chimeras and bispecific antibodies that activate or inhibit TGFβ signaling in a cell ...
Maarten van Dinther, Tristin Schwartze, Jiying Zhang, Kun Fan, Gerard van der Zon, Luke Power, Cynthia S. Hinck, Claire Ciancia, Ananya Mukundan, Roman Gonzalez‐Prieto, Peter van Veelen, Rick M. Maizels, Andrew P. Hinck, Peter ten Dijke   +13 more
wiley   +1 more source

Protecting Newborns from Multidrug-Resistant Infections: The Emerging Role of Bacteriophages

Viruses
Newborns may suffer from dangerous bacterial infections caused by life-threatening multi-drug resistant pathogens. Thus, despite bactericidal capabilities of antibiotics, microorganisms are known to circumvent this therapy, and a new, more effective type
Olaf Bajrak, Andrzej Górski, Ewa Jończyk-Matysiak   +2 more
doaj   +1 more source