Results 71 to 80 of about 48,920 (278)

Stability study in selected conditions and biofilm-reducing activity of phages active against drug-resistant Acinetobacter baumannii

Scientific Reports
Acinetobacter baumannii is currently a serious threat to human health, especially to people with immunodeficiency as well as patients with prolonged hospital stays and those undergoing invasive medical procedures.
Natalia Bagińska, Ilona Grygiel, Filip Orwat, Marek Adam Harhala, Adam Jędrusiak, Elżbieta Gębarowska, Sławomir Letkiewicz, Andrzej Górski, Ewa Jończyk-Matysiak   +8 more
doaj   +1 more source

Bacteriophage and Phage-Therapy: An Alternative to Antibiotics

, 2020
Bacteriophages are known for a century but their use in therapy to cure bacterial infection is still unknown. The working on bacteriophage investigation started about a century ago with their discovery by the English microbiologist Twort in 1915.
Soumya Srivastava*, Shruti Sinha
core   +1 more source

BACTERIOPHAGE THERAPY AS A TREATMENT STRATEGY FOR ORTHOPAEDIC-DEVICE-RELATED INFECTIONS: WHERE DO WE STAND? [PDF]

, 2020
Antibiotic resistance represents a key challenge of the 21st century. Since the pipeline of new antibiotics in development is limited, the introduction of alternative antimicrobial strategies is urgently required.
Metsemakers W. -J., Moriarty, T. F., Di Luca M., Pirnay, J.P., Gonzalez-Moreno, M., Di Luca, M., Moriarty, T.F., Trampuz A., Trampuz, A, Gonzalez-Moreno M., Lavigne R., Pirnay J. P., Wagemans, J., Trampuz, A., Onsea J., Metsemakers, W-J., Onsea, J., Di Lucas, M., Moriarty T. F., Lavigne, R., https://orcid.org/, Wagemans J., Pirnay, J. P.   +22 more
core   +1 more source

Optimization of B Cell Responses in Human Immune System Mice Through Organoid Based Screening

Advanced Science, EarlyView.
Human immune system (HIS) mice show limited B cell responses to immunization. Using HIS mouse spleen organoids, this study identifies cytokine combinations and innate immune signals that drive human B cell expansion, differentiation, and class‐switch. Applying these signals in vivo through temporal separation enables antigen‐specific IgG responses and ...
Haiqiao Sun, He Li, Xu Zhu, Zijian Zhang, Deshan Ren, Shuai Ding, Yan Li   +6 more
wiley   +1 more source

Sepsis, Phages, and COVID-19

Pathogens, 2020
Phage therapy has emerged as a potential novel treatment of sepsis for which no decisive progress has been achieved thus far. Obviously, phages can help eradicate local bacterial infection and bacteremia that may occur in a syndrome.
Andrzej Górski, Jan Borysowski, Ryszard Międzybrodzki   +2 more
doaj   +1 more source

Call for a Dedicated European Legal Framework for Bacteriophage Therapy

, 2014
The worldwide emergence of antibiotic resistances and the drying up of the antibiotic pipeline have spurred a search for alternative or complementary antibacterial therapies.
De Vos, Daniel, Huys, Isabelle, Lavigne, Rob, Verbeken, Gilbert, Pirnay, Jean-Paul, Casteels, Minne, Jennes, Serge   +6 more
core   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Safety Studies of Pneumococcal Endolysins Cpl-1 and Pal

Viruses, 2018
Bacteriophage-derived endolysins have gained increasing attention as potent antimicrobial agents and numerous publications document the in vivo efficacy of these enzymes in various rodent models. However, little has been documented about their safety and
Marek Harhala, Daniel C. Nelson, Paulina Miernikiewicz, Ryan D. Heselpoth, Beata Brzezicka, Joanna Majewska, Sara B. Linden, Xiaoran Shang, Aleksander Szymczak, Dorota Lecion, Karolina Marek-Bukowiec, Marlena Kłak, Bartosz Wojciechowicz, Karolina Lahutta, Andrzej Konieczny, Krystyna Dąbrowska   +15 more
doaj   +1 more source

Bacteriophage Therapy: Recent Developments and Applications of a Renaissance Weapon

The spreading antibiotic resistance of bacteria is one of the most important challenges of modern medicine, and a search for methods that could replace conventional treatments of bacterial infections is urgently needed.

core   +1 more source

What's Old Is New Again: Bacteriophage Therapy in the 21st Century. [PDF]

, 2019
We highlight features associated with bacteriophage therapy that make it an attractive treatment option for multidrug-resistant infections and also discuss some of the challenges that need to be considered in the design and execution of clinical trials ...
Schooley, Robert T, Aslam, Saima
core   +1 more source