Results 91 to 100 of about 48,920 (278)

“Phage Transplantation in Allotransplantation”: Possible Treatment in Graft-Versus-Host Disease?

Frontiers in Immunology, 2018
Graft-versus-host disease, both acute and chronic (aGvHD, cGvHD) remains a major complication in patients undergoing hematopoietic cell transplantation (HCT) and a significant therapeutic challenge, as many patients do not respond adequately to presently
Andrzej Górski, Andrzej Górski, Andrzej Górski, Ewa Jończyk-Matysiak, Ryszard Międzybrodzki, Ryszard Międzybrodzki, Ryszard Międzybrodzki, Beata Weber-Dąbrowska, Beata Weber-Dąbrowska, Jan Borysowski   +9 more
doaj   +1 more source

An investigation of the properties of bacteriophage M13 and the implications for its large-scale bioprocessing

, 2010
Bacteriophage are a diverse class of viruses that infect bacterial cells. As a result of over 60 years of molecular biology advances, bacteriophage today feature as candidates for vaccination, gene therapy, biomaterial and antibacterial purposes ...
Branston, S.D.
core  

Biomimetic Bone Marrow Monocyte Membrane‐Fused Extracellular Vesicles for Targeted Therapy of Myocardial Infarction

Advanced Science, EarlyView.
This study develops a biomimetic delivery system (M‐hEV) by fusing monocyte membranes with extracellular vesicles for targeted therapy of damaged cardiac tissue. The system homes to injured myocardium through specific molecular pathways. In a myocardial infarction model, M‐hEV effectively accumulates in the heart, reduces infarct size, alleviates ...
Jiaxin Song, Hao Yang, Qiqi Zhang, Wenqin Zhou, Rui Wang, Yuxing Xie, Emeli Chatterjee, Guoping Li, Jizong Jiang, Qiulian Zhou, Cuimei Zhao   +10 more
wiley   +1 more source

Phage Therapy: What Have We Learned?

Viruses, 2018
In this article we explain how current events in the field of phage therapy may positively influence its future development. We discuss the shift in position of the authorities, academia, media, non-governmental organizations, regulatory agencies ...
Andrzej Górski, Ryszard Międzybrodzki, Małgorzata Łobocka, Aleksandra Głowacka-Rutkowska, Agnieszka Bednarek, Jan Borysowski, Ewa Jończyk-Matysiak, Marzanna Łusiak-Szelachowska, Beata Weber-Dąbrowska, Natalia Bagińska, Sławomir Letkiewicz, Krystyna Dąbrowska, Jacques Scheres   +12 more
doaj   +1 more source

AI‐Designed Cyclic Peptides Enable Controllable Modulation of the CD28 Immune Checkpoint

Advanced Science, EarlyView.
AI‐designed cyclic peptides enable controllable modulation of the CD28 immune checkpoint through reversible disruption of CD28‐CD80/CD86 interactions. The lead peptide, CIP‐3, suppresses T‐cell activation without intrinsic agonist activity, demonstrates dose‐dependent efficacy in a murine colitis model, and attenuates inflammatory cytokine production ...
Katarzyna Kuncewicz, Saurabh Upadhyay, Renjie Zhu, Hongliang Duan, Moustafa T. Gabr   +4 more
wiley   +1 more source

Bacteriophage therapy to reduce Campylobacter jejuni colonization of broiler chickens [PDF]

, 2005
Colonization of broiler chickens by the enteric pathogen Campylobacter jejuni is widespread and difficult to prevent. Bacteriophage therapy is one possible means by which this colonization could be controlled, thus limiting the entry of campylobacters ...
Loc Carrillo, C., Dillon, E., Scott, A., Scott, A, Connerton, IF, Connerton, PL, Loc-Carrillo, CM, I. F. Connerton, Atterbury, Robert J., El-Shibiny, A., E. Dillon, Dillon, E, A. Scott, A. El-Shibiny, Connerton, Ian F., El-Shibiny, A, Connerton, Phillippa L., C. Loc Carrillo, R. J. Atterbury, P. L. Connerton, Atterbury, RJ   +20 more
core   +1 more source

Microblasting Wound Dressings Mechanically Disrupt Polymicrobial Biofilms to Enhance Healing in Treatment‐Resistant Wounds

Advanced Science, EarlyView.
Treatment‐resistant wounds caused by polymicrobial biofilms are refractory to conventional therapies due to the dense extracellular matrices. We developed μBLAST, a microblasting wound dressing that combines MnO2‐doped biosilica and a H2O2‐releasing mesh to generate localized oxygen microbubbles that mechanically disrupt biofilms.
Yujin Ahn, Joo Hun Lee, Christian Hurd, Jiye Lee, Junggeon Park, Adam A. Markowicz, Zheyuan Zhang, Joanne Hwang, Guillermo L. Monroy, Simon A. Rogers, Woonggyu Jung, Stephen A. Boppart, Hyunjoon Kong   +12 more
wiley   +1 more source

Phage Therapy in Prostatitis: Recent Prospects

Frontiers in Microbiology, 2018
Prostatitis has various etiology including bacterial infection and dysregulated immunity; some of its forms remain a serious therapeutic challenge. Inflammation occurs in all forms of this disorder and is proposed to predispose to the development of ...
Andrzej Górski, Andrzej Górski, Andrzej Górski, Ewa Jończyk-Matysiak, Marzanna Łusiak-Szelachowska, Ryszard Międzybrodzki, Ryszard Międzybrodzki, Ryszard Międzybrodzki, Beata Weber-Dąbrowska, Beata Weber-Dąbrowska, Jan Borysowski, Sławomir Letkiewicz, Sławomir Letkiewicz, Natalia Bagińska, Karen S. Sfanos, Karen S. Sfanos, Karen S. Sfanos   +16 more
doaj   +1 more source

Bacteriophage-based therapy in cystic fibrosis-associated Pseudomonas aeruginosa infections: rationale and current status

, 2015
Sami Hraiech,1,2 Fabienne Brégeon,1,3 Jean-Marc Rolain1 1Institut Hospitalo-Universitaire Méditerranée Infection, URMITE CNRS IRD INSERM UMR 7278, 2Réanimation Médicale – Détresses Respiratoires et ...
Brégeon F, Rolain JM, Hraiech S
core  

Nanomaterials for Allergy Diagnosis and Treatment: Advances, Opportunities and Translational Challenges

Advanced Science, EarlyView.
Nanomaterials offer dual applications in allergy management. For diagnosis, nanomaterials enhance analytical sensitivity and improve detection in specific IgE and functional assays such as the basophil activation test (BAT). For allergen‐specific immunotherapy, nanomaterials enable allergen masking and controlled release, and effectively modulate the ...
Madiha Habib, Shan Jiang, Joyce ZX Lee, CW Lim, HL Yeung, Nicki YH Leung, Patrick SC Leung, Ting F Leung, Christine YY Wai   +8 more
wiley   +1 more source