Results 171 to 180 of about 48,920 (278)

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

The Role of Genomics in Advancing and Standardising Bacteriophage Therapy. [PDF]

Antibiotics (Basel)
Abdraimova N, Shitikov E, Kornienko M.
europepmc   +1 more source

Multivalent antibody‐based conjugates as new tools for tailored modulation of G protein–coupled receptors

British Journal of Pharmacology, EarlyView.
The G protein–coupled receptor (GPCR) superfamily consists of the most common targets of approved drugs. Targeting GPCRs offers appealing avenues for therapeutic development. Antibodies and their fragments, such as single‐domain antibodies (VHHs or nanobodies), have emerged as useful alternatives to small molecule pharmacophores as building blocks in ...
Shivani Sachdev, Ross W. Cheloha
wiley   +1 more source

Bacteriophage Therapy Against <i>Shigella</i> spp.: A Precision Antimicrobial Strategy. [PDF]

Antibiotics (Basel)
Scarlata GGM, Belančić A, Štimac D, Fajkić A, Meštrović T, Abenavoli L.   +5 more
europepmc   +1 more source

Microbiome–Driven Carcinogenesis and Circulating Microbial Signals in Genitourinary Cancers

Cancer Science, EarlyView.
Experimental BBN models link gut microbial metabolism and diet‐microbiome interactions to urothelial carcinogenesis, while circulating extracellular vesicle‐associated bacterial DNA signals may reflect tumor immune contexture and immune checkpoint inhibitor outcomes in urothelial and renal cell carcinoma.
Atsunari Kawashima, Kentaro Jingushi, Takuro Saito, Toshihiro Uemura, Akinaru Yamamoto, Nesrine Sassi, Hiromu Horitani, Shunsuke Inoguchi, Yuki Horibe, Yu Ishizuya, Takuji Hayashi, Yoshiyuki Yamamoto, Norio Nonomura   +12 more
wiley   +1 more source

Bacteriophage therapy for multidrug-resistant pediatric infections: a re-emerging precision antimicrobial strategy. [PDF]

Ann Med Surg (Lond)
Amjad A, Shahzad A, Segawa F.
europepmc   +1 more source

Unveiling Gut Homeostasis Disruption in Sepsis: Towards an Integrated Mechanistic and Translational Roadmap

Cell Proliferation, EarlyView.
Elucidating the contribution of gut‐organ axes will provide new insights for developing combined therapeutic strategies against sepsis‐associated multiple organ dysfunction. ABSTRACT Sepsis, a life‐threatening clinical syndrome precipitated by a maladaptive host response to infection, is associated with substantial morbidity and high mortality rates ...
Yichen Bao, Lin Qi, Guijun Zou, Xingpeng Yang, Yizhao Ma, Zhifu Li, Xiaohui Du, Pengyue Zhao   +7 more
wiley   +1 more source

Bacteriophage therapy against multidrug resistant bacterial infections demonstrates clinical advances and engineering innovations between 2020-2026. [PDF]

Front Microbiol
Alzahrani AJ.
europepmc   +1 more source

Bacteriophage Interactions With Epithelial Cells: Therapeutic Implications

Frontiers in Microbiology, 2021
Andrzej Górski, Andrzej Górski, Andrzej Górski, Jan Borysowski, Ryszard Miȩdzybrodzki, Ryszard Miȩdzybrodzki, Ryszard Miȩdzybrodzki   +6 more
doaj   +1 more source

The use of bacteriophage therapy for curing the Escherichia coli 0157 infection in mice

, 2015
Background: Diarrhea is still a problem in public health, especially in developing country such as Indonesia. Escherichia coli 0157:H7 {Enterohemorrhagic Escherichia coli (EHEC)} is one of the important strains as the etiology of bloody diarrhea with ...
Metha Restu, Rio Rendy, Hera Nirwati, Susi Iravati, Mova Aria, Ida Ayu Putu
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