Results 91 to 100 of about 15,598 (206)

The Mechanism of Peptide Hydrolysis Catalysed by Dipeptidyl Peptidase III from Bacteroides thetaiotaomicron [PDF]

, 2018
Dipeptidyl peptidase III (DPP III) is a zinc- dependent peptidase that cleaves dipeptides off of N-termini of its substrates. Previous studies on human DPP III reveal a reaction mechanism similar to that of thermolysin. Since the active site is conserved
Kovačević, Borislav, Tomin, Marko, Tomić, Antonija, Tomić, Sanja   +3 more
core   +2 more sources

Bifidobacterium bifidum G9‐1 Intake Improves Gastrointestinal Symptoms in Type 2 Diabetes Mellitus: An Open‐Label, Randomized Controlled Trial (Binary STAR Study)

Diabetes, Obesity and Metabolism, Volume 28, Issue 7, Page 5952-5967, July 2026.
ABSTRACT Aims To evaluate the effects of probiotics Bifidobacterium bifidum G9‐1 (BBG9‐1) on gastrointestinal symptoms in patients with Type 2 diabetes mellitus (T2DM) with diarrhoea or constipation. Materials and Methods In a 12‐week open‐label randomised controlled trial, 100 participants were randomized 1:1 to a control or BBG9‐1 group, with 12 mg ...
Genki Kobayashi, Yoshitaka Hashimoto, Tomoyuki Matsuyama, Noriyuki Kitagawa, Saori Majima, Takafumi Senmaru, Emi Ushigome, Hiroshi Okada, Naoko Nakanishi, Masahide Hamaguchi, Michiaki Fukui   +10 more
wiley   +1 more source

Developing a Bacteroides System for Function-Based Screening of DNA from the Human Gut Microbiome

mSystems, 2018
Functional metagenomics is a powerful method that allows the isolation of genes whose role may not have been predicted from DNA sequence. In this approach, first, environmental DNA is cloned to generate metagenomic libraries that are maintained in ...
Kathy N. Lam, Eric C. Martens, Trevor C. Charles   +2 more
doaj   +1 more source

Crystal structure of dipeptidyl peptidase III from the human gut symbiont Bacteroides thetaiotaomicron. [PDF]

PLoS ONE, 2017
Bacteroides thetaiotaomicron is a dominant member of the human intestinal microbiome. The genome of this anaerobe encodes more than 100 proteolytic enzymes, the majority of which have not been characterized.
Igor Sabljić, Nevenka Meštrović, Bojana Vukelić, Peter Macheroux, Karl Gruber, Marija Luić, Marija Abramić   +6 more
doaj   +1 more source

Modelling the emergent dynamics and major metabolites of the human colonic microbiota [PDF]

, 2015
Funded by Scottish Government's Rural and Environment Science and Analytical Services Division (RESAS) Acknowledgements We would like to thank Thanasis Vogogias, David Nutter and Alec Mann for their assistance in developing the software for this model ...
Aminov, Bagramyan, Barcenilla, Bratbak, Cotillard, David, Drake, Duncan, Duncan, Duncan, Duncan, Duncan, Duncan, Eckburg, Egert, Feijó Delgado, Filippo, Flint, Flint, Flint, Gottschalk, Kettle, Kovarova-Kovar, Latham, Liu, Lopez-Siles, Louis, Louis, Macfarlane, Marquet, Moore, Munoz-Tamayo, Nava, Norberg, Prins, Qin, Ragsdale, Reichardt, Richardson, Robert, Rogers, Russell, Salyers, Seeliger, Stephen, Swidsinski, Tap, Turnbaugh, Walker, Walker, Walker, Whitman, Wolin, Wu, Yachi, Ze   +55 more
core   +1 more source

Maternal Preconception Antibiotic Exposure Disrupts Microbial Succession: A Transgenerational Risk for Offspring Gut Mucosal Immaturity and Colitis Susceptibility

Advanced Science, Volume 13, Issue 29, 22 May 2026.
This study reveals that maternal antibiotic exposure prior to conception disrupts intergenerational gut microbial succession. By enhancing maternal‐offspring microbial transmission, altering microbial developmental trajectories and increasing selective pressures during community assembly, these disturbances lead to persistent gut mucosal immaturity and
Yuzhu Chen, Ruqiao Duan, Cunzheng Zhang, Gaonan Li, XiaoLin Ji, Qi Zhang, Fei Pei, Kun Wang, Liping Duan   +8 more
wiley   +1 more source

Use of randomly cloned DNA fragments for identification of Bacteroides thetaiotaomicron [PDF]

Journal of Bacteriology, 1983
Randomly cloned fragments of DNA from Bacteroides thetaiotaomicron were used as hybridization probes for differentiation of B. thetaiotaomicron from closely related Bacteroides species. HindIII digestion fragments of DNA from B. thetaiotaomicron (type strain) were inserted into plasmid pBR322 and labeled with [alpha-32P]dCTP by nick translation.
A A, Salyers, S P, Lynn, J F, Gardner
openaire   +2 more sources

Distinct effects of different Bacteroides strains on depressive-like behavior via a gut-Th1/Th17 cells-brain axis

Communications Biology
Extensive evidence links gut microbiota to the pathogenesis of major depressive disorder (MDD), yet the specific microbial species involved remain unclear. Here, we identify distinct roles of three Bacteroides species—B. uniformis, B.
Zhiyu Li, Peilin Qin, Zuoli Sun, Liangkang Li, Peng Liang, Yimei Zhao, Siyu Ren, Gang Wang, Jian Yang   +8 more
doaj   +1 more source

Effects of diet on resource utilization by a model human gut microbiota containing Bacteroides cellulosilyticus WH2, a symbiont with an extensive glycobiome [PDF]

, 2013
The human gut microbiota is an important metabolic organ, yet little is known about how its individual species interact, establish dominant positions, and respond to changes in environmental factors such as diet.
Erickson, Alison R., Erickson, Brian K., Gordon, Jeffrey I., Henrissat, Bernard, Hettich, Robert L., Martens, Eric C., McNulty, Nathan P., Meng, Wu, Muegge, Brian D., Pan, Chongle, Pudlo, Nicholas A., Wu, Meng   +11 more
core   +5 more sources

Multicohort Validation of Gut Microbiome Signatures for Cholangiocarcinoma Diagnosis and Functional Characterization of Bifidobacterium Pseudocatenulatum

Advanced Science, Volume 13, Issue 27, 13 May 2026.
This study analyzes gut bacteria in cholangiocarcinoma patients, revealing distinct microbial signatures that enable accurate disease detection. Species‐based diagnostic models achieved over 98% accuracy in identifying cholangiocarcinoma and distinguished it from other liver diseases. The research demonstrates that specific beneficial bacteria suppress
Benchen Rao, Jianwen Jiang, Ruiqing Zhang, Dongya Zhang, Chenchen Zhang, Ang Li, Haifeng Lu, Hua Zhang, Lin Zhou, Wenzhi Guo, Peihao Wen, Jianfeng Xue, Jie Pan, Tuerganaili Aji, Zhou Lan, Xianzhi Jiang, Shusen Zheng, Zujiang Yu, Zhigang Ren   +18 more
wiley   +1 more source