The Role of the Gut Microbiota in Allogeneic Hematopoietic Cell Transplantation
American Journal of Hematology, EarlyView.ABSTRACT Allogeneic hematopoietic cell transplantation (allo‐HCT) is an effective treatment for patients with high‐risk hematologic malignancies. Over the last decade, gut microbiota composition during allo‐HCT has been associated with patients' outcomes.
Wenjing Hao +4 more
wiley +1 more source
Para-cresol production by Clostridium difficile affects microbial diversity and membrane integrity of Gram-negative bacteria [PDF]
, 2018 Clostridium difficile is a Gram-positive spore-forming anaerobe and a major cause of antibiotic-associated diarrhoea. Disruption of the commensal microbiota, such as through treatment with broad-spectrum antibiotics, is a critical precursor for ...
Baines, Simon D +12 more
core +6 more sources
Introduction of the Bacteroides ruminicola xylanase gene into the Bacteroides thetaiotaomicron chromosome for production of xylanase activity [PDF]
Applied and Environmental Microbiology, 1991 The xylanase gene from the ruminal bacterium Bacteroides ruminicola 23 is highly expressed in colonic Bacteroides species when carried on plasmid pVAL-RX. In order to stabilize xylanase expression in the absence of antibiotic selection, the xylanase gene was introduced into the chromosome of Bacteroides thetaiotaomicron 5482 by using suicide vector ...
T R, Whitehead, M A, Cotta, R B, Hespell
openaire +2 more sources
Molecular monitoring of the fecal microbiota of healthy human subjects during administration of lactulose and Saccharomyces boulardii [PDF]
, 2006 A
Vanhoutte, Tom +5 more
core +2 more sources
Modulation of Animal Gut Health by Milk Oligosaccharide
Animal Research and One Health, EarlyView.This review summarizes the composition and structural characteristics of MOs across different mammalian species, and elucidates their roles and mechanisms in maintaining intestinal homeostasis by regulating gut microbiome and enhancing intestinal chemical, physical and immune barriers.
Ningtao Chen +7 more
wiley +1 more source
MicrobiologyOpenThe gut microbiota significantly contributes to human health and well‐being. The aim of this study was to evaluate the stability and resilience of a consortium composed of three next‐generation probiotics (NGPs) candidates originally found in the human ...
Anna Kattel +6 more
doaj +1 more source
Antibiotic Remodeling of the Gut Microbiota Impairs Host Resistance to Secondary Infection
iMetaMed, EarlyView.Gut microbial dynamics induced by four antibiotics, revealed distinct taxonomic and functional shifts. Vancomycin‐perturbed bacteriomes were proven to promote pathogen resistance to antibiotic treatment. Metronidazole‐treated mice showed pronounced Salmonella translocation to hepatic tissue, and altered Enterococcus avium populations modulated host ...
Miaoyu Li +17 more
wiley +1 more source
Gnotobiotic Rodents: An In Vivo Model for the Study of Microbe–Microbe Interactions [PDF]
, 2016 Germ-free rodents have no microorganisms living in or on them, allowing researchers to specifically control an animal’s microbiota through the direct inoculation of bacteria of interest.
Luis G. Bermúdez-Humarán +2 more
core +3 more sources
iMetaOmics, EarlyView.The “efficacy paradox” of phytochemicals, low bioavailability yet significant health benefits, is associated with gut microbiota, which biotransforms dietary precursors into bioactive metabolites, enabling systemic effects. Thus, health outcomes of diet depend not just on intake “the rainbow”, but on gut microbial metabolism, redefining “you are what ...
Peng Yang, Ren‐You Gan
wiley +1 more source
Structural basis of mammalian high-mannose N-glycan processing by human gut Bacteroides
Nature Communications, 2020 Human gut bacteria depolymerize glycans into their sugar components, which otherwise cannot be processed by their host. Here, the authors characterise the endo-β-N-acetylglucosaminidase EndoBT-3987 from the Gram-negative symbiont Bacteroides ...
Beatriz Trastoy +7 more
doaj +1 more source