Results 41 to 50 of about 73,636 (212)

Recombinant neuraminidase pseudotyped baculovirus: a dual vector for delivery of Angiotensin II peptides and DNA vaccine

AMB Express, 2018
Baculovirus is a promising vaccine deliver vector due to its biosafety profiles, gene transfer efficiency, ability to display small foreign antigens on its surface, strong adjuvant activities, etc.
Irisa Trianti, Saengchai Akeprathumchai, Phenjun Mekvichitsaeng, Sansanalak Rachdawong, Kanokwan Poomputsa   +4 more
doaj   +1 more source

The Complete Genome Sequence of Plodia Interpunctella Granulovirus: Evidence for Horizontal Gene Transfer and Discovery of an Unusual Inhibitor-of-Apoptosis Gene. [PDF]

PLoS ONE, 2016
The Indianmeal moth, Plodia interpunctella (Lepidoptera: Pyralidae), is a common pest of stored goods with a worldwide distribution. The complete genome sequence for a larval pathogen of this moth, the baculovirus Plodia interpunctella granulovirus (PiGV)
Robert L Harrison, Daniel L Rowley, C Joel Funk   +2 more
doaj   +1 more source

The Drosophila DIAP1 protein is required to prevent accumulation of a continuously generated, processed form of the apical caspase DRONC [PDF]

, 2002
Although loss of the inhibitor of apoptosis (LAP) protein DIAP1 has been shown to result in caspase activation and spontaneous cell death in Drosophila cells and embryos, the point at which DIAP1 normally functions to inhibit caspase activation is ...
Clem, Rollie J., Hay, Bruce A., Muro, Israel   +2 more
core   +1 more source

Baculovirus and Insect Cell Gene Expression: Review of Baculovirus Biotechnology [PDF]

Environmental Health Perspectives, 1995
The BEVS continues to evolve as a powerful, flexible tool for molecular biology, protein function, and biomedical research. Future developments offer the promise of replacement of hazardous chemical insecticides with environmentally safe biopesticides, construction of baculovirus vectors which encode genes for specific post-translational modifications,
R M Patterson, J K Selkirk, B A Merrick
openaire   +1 more source

Performance of large virus removal filters during AAV processing: Influence of flux and process disruptions

Biotechnology Progress, EarlyView.
Abstract As adeno‐associated viral vectors (AAV) continue to advance through the clinical pipeline, effective downstream purification strategies must be developed to ensure bulk drug purity and safety. AAV are produced within mammalian cells, bringing forth risks associated with viral contamination.
Akshay S. Chaubal, Asingsa W. Arachchige, Annabelle J. Zahn, S. Ranil Wickramasinghe, Xianghong Qian, Andrew L. Zydney   +5 more
wiley   +1 more source

Anti-tumor activity of Escherichia coli Shiga toxin A subunit delivered by SF9 insect cells

Journal of Pharmacological Sciences, 2018
Cancer remains a major health problem around the world. A Shiga toxin is a bacterial toxin often produced by Shigella dysenteriae and Escherichia coli. A subunit of the Shiga toxin (StxA) is a cytotoxic agent which could be used to induce death in cancer
Mana Oloomi, Maryam Imani, Ramezan Behzadi, Mohsen Asori, Saeid Bouzari, Bita Mokhlesi   +5 more
doaj   +1 more source

Expression of an innate immune element (mouse hepcidin-1) in baculovirus expression system and the comparison of its function with synthetic human hepcidin-25 [PDF]

, 2011
Hepcidin is an innate immune element which decreases the iron absorption from diet and iron releasing from macrophage cell. In contrast to the chemical iron chelators, there has been limited effort applied to the specific use of hepcidin as a new drug ...
Alimohammadian, M., Andalib, A., Moazen, F., Rezaei, A., Sadeghi, H., Yazdani, Y.   +5 more
core   +1 more source

Gad65 is recognized by t-cells, but not by antibodies from nod-mice [PDF]

, 1994
Since the 64kDa-protein glutamic acid decarboxylase (GAD) is one of the major autoantigens in T-cell mediated Type 1 diabetes, its relevance as a T-cell antigen needs to be clarified. After isolation of splenic T-cells from non-obese diabetic (NOD) mice,
Alzari PM, Atkinson MA, Baekkeskov S, Bieg S, Christgau S, Christie MR, Diaz JL, Eisenbarth GS, Hackett CJ, Honeyman MC, J. Seissler, Jennings PA, L. Herberg, Leiter EH, Lie W, Mauch L, Miller LP, Ohneda A, Peters PJ, Roep BO, Roep BO, S. Bieg, Seissler J, Seissler J, Solimena M, Solimena M, Velloso LA, W. A. Scherbaum, W. Northemann   +28 more
core   +1 more source

Protocol for Reconstituting Adaptor‐Mediated Activation of Full‐Length Kinesin‐1

Cytoskeleton, EarlyView.
ABSTRACT Kinesin‐1 is a member of the kinesin superfamily that plays an essential role in intracellular cargo transport. In the absence of cargo, Kinesin‐1 exhibits low motor activity due to autoinhibition. Multiple studies have demonstrated that adaptor proteins, which link cargos to Kinesin‐1, can activate Kinesin‐1 by releasing the autoinhibition ...
Haruka Masumoto, Kyoko Chiba
wiley   +1 more source

Residual baculovirus in insect cell-derived influenza virus-like particle preparations enhances immunogenicity.

PLoS ONE, 2012
Influenza virus-like particles are currently evaluated in clinical trials as vaccine candidates for influenza viruses. Most commonly they are produced in baculovirus- or mammalian- expression systems.
Irina Margine, Luis Martinez-Gil, Yi-Ying Chou, Florian Krammer   +3 more
doaj   +1 more source