Results 61 to 70 of about 52,750 (225)
BMC Microbiology, 2008 Background The worldwide outbreak of influenza A (H5N1) viruses among poultry species and humans highlighted the need to develop efficacious and safe vaccines based on efficient and scaleable production. Results White spot syndrome virus (WSSV) immediate-
Yu Li, Ho YuenFern, He Fang, Kwang Jimmy
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Frontiers in Immunology, 2020 Although the modulation of host physiology has been interpreted as an essential process supporting baculovirus propagation, the requirement of energy supply for host antivirus reactions could not be ruled out.
Yu-Hsien Lin +8 more
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Status and future of recombinant adeno‐associated virus vector manufacturing
Biotechnology Progress, EarlyView.Abstract Sixty years of adeno‐associated virus (AAV) research illustrates a trajectory marked by basic science exploration, iterative innovation, persistent challenges, a number of clinical setbacks, as well as commercial therapeutic triumphs. This continual evolution has led to recombinant AAV (rAAV) becoming a cornerstone of modern gene therapy ...
Frank Agbogbo, David Dismuke
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, 2023 Baculoviruses are arthropod-specific viruses containing large double-stranded circular DNA genomes of 80,000–180,000 bp. In recent years, they have been utilized for producing complex eukaryotic proteins in insect cell cultures.
Marcia Brady
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Development of a replication-defective baculovirus platform [PDF]
, 2020 Baculovirus expression vector systems are used for the production of an increasing number of licensed commercial subunit vaccines. Though baculoviruses are incapable of replicating outside a narrow host range of lepidopteran insects, a replication ...
Ackerman, Scott
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RNA transmission and expression from inert HIV candidate vaccine virus-like-particles [PDF]
, 2008 Includes abstract.Includes bibliographical references (leaves 136-158).HIV-1 Gag virus-like-particles (VLPs) produced in various expression systems are potent stimulators of both cellular and humoral immune responses in animal models.
Valley-Omar, Ziyaad
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Increase in gut microbiota after immune suppression in baculovirus-infected larvae.
PLoS Pathogens, 2013 Spodoptera exigua microarray was used to determine genes differentially expressed in S. exigua cells challenged with the species-specific baculovirus SeMNPV as well as with a generalist baculovirus, AcMNPV.
Agata K Jakubowska +2 more
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Inhibition of melanization by serpin-5 and serpin-9 promotes baculovirus infection in cotton bollworm Helicoverpa armigera. [PDF]
PLoS Pathogens, 2017 Melanization, an important insect defense mechanism, is mediated by clip-domain serine protease (cSP) cascades and is regulated by serpins. Here we show that proteolytic activation of prophenoloxidase (PPO) and PO-catalyzed melanization kill the ...
Chuanfei Yuan +7 more
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Demonstration of nanofiltration‐based virus safety for AAV manufacturing using model viruses
Biotechnology Progress, EarlyView.Abstract Virus safety for biopharmaceutical products has been a well‐established concern for several decades. While various virus reduction steps have been identified and implemented for traditional plasma‐derived and monoclonal antibody products, there are various challenges to achieving the same virus safety in emerging gene therapy products.
Brian Buesing +2 more
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Baculovirus structural proteins
Journal of General Virology, 1992 Introduction. Baculovirus biology. The Baculoviridae are a diverse family of virus pathogens which are infectious for arthropods, particularly insects of the order Lepidoptera. They have also been isolated from the insect orders Hymenoptera, Diptera and Trichoptera, as well as from the crustacean order Decapoda (shrimp) (Couch, 1974).
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