Results 71 to 80 of about 39,940 (191)

Baculovirus vector-mediated transfer of sodium iodide symporter and plasminogen kringle 5 genes for tumor radioiodide therapy.

PLoS ONE, 2014
BackgroundBoth tumor cells and their supporting endothelial cells should be considered for targeted cell killing when designing cancer treatments.
Min Zhang, Rui Guo, Shuo Shi, Yin Miao, Yifan Zhang, Biao Li   +5 more
doaj   +1 more source

A novel selective stabilizer of the ryanodine receptor 2 prevents stress‐induced ventricular arrhythmias without impairing cardiac function

British Journal of Pharmacology, Volume 183, Issue 15, Page 4321-4343, August 2026.
Abstract Background and Purpose Aberrant activation of type 2 ryanodine receptors (RyR2) causes lethal arrhythmias, such as catecholaminergic polymorphic ventricular tachycardia (CPVT). Developing drugs that suppress RyR2 hyperactivation may be key to novel arrhythmia treatments.
Nagomi Kurebayashi, Masami Kodama, Hana Inoue, Masato Konishi, Masami Sugihara, Takashi Murayama, Ryosuke Ishida, Koichiro Ishii, Shuichi Mori, Yukari Endo, Xi Zeng, Yukiko U. Inoue, Takayoshi Inoue, Satoru Noguchi, Hajime Nishio, Eri Nakashima, Norio Suzuki, Noriko Nakaya, Ryushi Sato, Yuya Otori, Ayuna Tsutsumi, Mirei Takahashi, Takayuki Oka, Haruo Ogawa, Kayoko Kanamitsu, Hiroyuki Kusuhara, Utako Yokoyama, Junko Kurokawa, Hiroyuki Kagechika, Takashi Sakurai   +29 more
wiley   +1 more source

Development of a baculovirus vector carrying a small hairpin RNA for suppression of sf-caspase-1 expression and improvement of recombinant protein production

BMC Biotechnology, 2018
Background The Baculovirus expression vector system (BEVS) is a transient expression platform for recombinant protein production in insect cells. Baculovirus infection of insect cells will shutoff host translation and induce apoptosis and lead to the ...
Xiaoyue Zhang, Keyan Xu, Yanmei Ou, Xiaodong Xu, Hongying Chen   +4 more
doaj   +1 more source

Baculovirus structural proteins

Journal of General Virology, 1992
Introduction. Baculovirus biology. The Baculoviridae are a diverse family of virus pathogens which are infectious for arthropods, particularly insects of the order Lepidoptera. They have also been isolated from the insect orders Hymenoptera, Diptera and Trichoptera, as well as from the crustacean order Decapoda (shrimp) (Couch, 1974).
openaire   +2 more sources

Directional and direct cloning strategy for high-throughput generation of recombinant baculoviruses

BioTechniques, 2006
The baculovirus expression vector system (BEVS) has become one of the most widely used systems for routine protein expression. We have developed an improved strategy to clone foreign genes directionally and directly into the baculovirus genome vector via
Qi Ma, Li Zhou, Lixin Ma, Keke Huo
doaj   +1 more source

Development of a Trivalent Seasonal Influenza Vaccine Using Long α‐Helix‐Mediated Trimeric HA1 Proteins Produced in Baculovirus‐Insect Cell System

MedComm, Volume 7, Issue 8, August 2026.
Ning Guo, Zhibin Xu, Xinyu Chen, Xiaonan Han, Ting Xue, Jinghua Yan, Qingrui Huang   +6 more
wiley   +1 more source

Evaluation of recombinant baculovirus clearance during rAAV production in Sf9 cells using a newly developed fluorescent-TCID50 assay

Frontiers in Medicine
IntroductionRecombinant adeno-associated virus (rAAV) vectors provide a safe and efficient means for in vivo gene delivery, although its large-scale production remains challenging. Featuring high manufacturing speed, flexible product design, and inherent
Ningguang Luo, Xiangqun Chen, Jinzhong Li, Derrick Huynh, Ying Li, Li Ou, Shengjiang Liu   +6 more
doaj   +1 more source

A viral expression factor behaves as a prion

Nature Communications, 2019
Prion-forming proteins have been found in animals, plants, fungi, and bacteria. Here, Nan et al. report that a baculovirus-encoded protein behaves as prion in a yeast system and forms aggregates at high multiplicity of infection in insect cells that ...
Hao Nan, Hongying Chen, Mick F. Tuite, Xiaodong Xu   +3 more
doaj   +1 more source

LEF-6 phosphorylation regulates the binding and trafficking of baculovirus late gene transcripts

Journal of Virology
The Autographa californica multiple nucleopolyhedrovirus (AcMNPV) LEF-6 has been shown to accelerate the infection cycle of AcMNPV, but its specific function is yet to be defined.
Xiaoyue Zhang, Zhihui Zhang, Ziqian Cao, Jianchao Li, Shengqiang Jiang, Hongying Chen   +5 more
doaj   +1 more source

Improving the production of baculovirus expression vector by overexpression of IE0/IE1 through tandem promoter.

PLoS ONE
The baculovirus expression vector system, known for its protein production in insect cells and has been criticized for its relatively low expression capacity.
Sijun He, Weining Li, Ruirui Zhang, Hao Nan, Wangcheng Song, Xiaodong Xu   +5 more
doaj   +1 more source