Results 91 to 100 of about 52,750 (225)

The Role of Oxidative Stress in Periodontitis

Journal of Periodontal Research, EarlyView.
Oxidative stress is involved in multiple chemical reactions that take place in different intracellular organelles: mitochondria, rough endoplasmic reticulum, peroxisomes, autophagy, and aging, and can be influenced by exogenous factors: nutrition, physical activity, psychological status, environmental conditions, microbiome, and drugs.
Pedro Bullon, Francesca Giampieri, Beatriz Bullon, Maurizio Battino   +3 more
wiley   +1 more source

Directional and direct cloning strategy for high-throughput generation of recombinant baculoviruses

BioTechniques, 2006
The baculovirus expression vector system (BEVS) has become one of the most widely used systems for routine protein expression. We have developed an improved strategy to clone foreign genes directionally and directly into the baculovirus genome vector via
Qi Ma, Li Zhou, Lixin Ma, Keke Huo
doaj   +1 more source

Rice Orange Leaf Phytoplasma Imp Protein Blocks G–M Interaction by Binding Glycoprotein G to Suppress Rice Stripe Mosaic Virus Infection

Plant, Cell &Environment, EarlyView.
ABSTRACT Plants frequently encounter multiple pathogens concurrently, yet the molecular bases of pathogen–pathogen interactions during mixed infections remain largely unresolved. Here we show that co‐infection of rice by Rice orange leaf phytoplasma (ROLP) and Rice stripe mosaic virus (RSMV) markedly suppresses RSMV proliferation in both host plants ...
Jiaxin Qiu, Yujiao Zheng, Yanmei Yi, Yuxin Zhang, Tianbao Zeng, Hongyan Chen, Taiyun Wei, Xiao‐Feng Zhang   +7 more
wiley   +1 more source

Allosteric Inhibition of Polycomb Repressive Complex 2 by an EZH2‐Selective Small Molecule Inhibitor

Advanced Science, Volume 13, Issue 49, 3 September 2026.
The study characterizes C36, a highly selective EZH2/PRC2 inhibitor that acts via a novel allosteric mechanism. Unlike previous inhibitors, C36 inhibits EZH2/PRC2 by disrupting the allosteric communication between EZH2 and EED in a SAM‐noncompetitive manner.
Ting Cao, Dongdong Liu, Haishan Gao, Chenyang Qin, Wen Zhang, Ziyun Lu, Dongxia Tan, Yuxiu Qu, Yusong Liu, Zhiran Zou, Hongtao Yu, Wei Qi   +11 more
wiley   +1 more source

Nucleases and Their Inhibitors: Exploring Biological Roles, Industrial Applications, and Challenges in Heterologous Expression

Biotechnology Journal, Volume 21, Issue 9, September 2026.
Graphical Abstract and Lay Summary Intracellular nucleases, depicted as blue circles in a nucleosome, hydrolyze phosphodiester bonds, repair damaged DNA using DNA base excision repair (BER), mismatch repair (MMR), and homologous recombination (HR), and are involved in DNA replication.
Wian Vermeulen, Anton Du Preez van Staden, Leon M. T. Dicks   +2 more
wiley   +1 more source

Active pH Modulation by Proton Channel‐Peptide Nucleic Acid Complex for Effective siRNA Endosomal Escape

Small, Volume 22, Issue 53, 21 September 2026.
A bioinspired siRNA nanocarrier is engineered by integrating an influenza A M2 proton channel with siRNA through a peptide nucleic acid linker on liposome surfaces. Active proton transport amplifies osmotic stress within endosomes, triggering membrane rupture and cytosolic release.
Seongmin Ga, Nam Hyeong Kim, Si Yeon Ryu, Kyeonghyun Kim, Eun Sung Kang, Hayeon Bae, Seungmin Ryu, Suhyeon Kim, Yeontae Jang, Bok‐Soo Lee, Jiyoung Nam, Minah Suh, Jaecheol Lee, Seung‐gu Kang, Jaekyung Hyun, Huong T. Kratochvil, Yong Ho Kim   +16 more
wiley   +1 more source

Probability to produce animal vaccines in insect baculovirus expression system [PDF]

, 2013
The insect baculovirus expression system is a valuable tool for the production of vaccine. Many subunit vaccines have been expressed in this system. The first vaccine produced in insect cells for animal use is now in the market.
Roy, B, Miao, YG, Zhou, F, Zhang, P, Wang, MX, David, WCC, Liang, S   +6 more
core   +1 more source

Baculovirus vector-mediated transfer of sodium iodide symporter and plasminogen kringle 5 genes for tumor radioiodide therapy.

PLoS ONE, 2014
BackgroundBoth tumor cells and their supporting endothelial cells should be considered for targeted cell killing when designing cancer treatments.
Min Zhang, Rui Guo, Shuo Shi, Yin Miao, Yifan Zhang, Biao Li   +5 more
doaj   +1 more source

Development of a baculovirus vector carrying a small hairpin RNA for suppression of sf-caspase-1 expression and improvement of recombinant protein production

BMC Biotechnology, 2018
Background The Baculovirus expression vector system (BEVS) is a transient expression platform for recombinant protein production in insect cells. Baculovirus infection of insect cells will shutoff host translation and induce apoptosis and lead to the ...
Xiaoyue Zhang, Keyan Xu, Yanmei Ou, Xiaodong Xu, Hongying Chen   +4 more
doaj   +1 more source

KAT6A–inhibitor co‐crystal structures: tackling a challenging crystallization target via two alternative approaches

Acta Crystallographica Section D, Volume 82, Issue 9, Page 1111-1124, September 2026.
We report a novel cysteine‐to‐serine surface‐mutation approach to determine co‐crystal structures of KAT6A with small‐molecule inhibitors and compare it with the previously published MYSTcryst approach which uses mutated KAT8 as a surrogate for KAT6A.
Vera Puetter, Léa Bouché, Katrin Nowak-Reppel, Steven J. Ferrara, Stefan N. Gradl, Daniel Korr, Craig A. Strathdee, Antonius ter Laak, Roman C. Hillig   +8 more
wiley   +1 more source