Results 1 to 10 of about 94 (88)

MD-ALL: an integrative platform for molecular diagnosis of B-acute lymphoblastic leukemia

Haematologica, 2023
B-acute lymphoblastic leukemia (B-ALL) consists of dozens of subtypes defined by distinct gene expression profiles (GEP) and various genetic lesions. With the application of transcriptome sequencing (RNA sequencing [RNA-seq]), multiple novel subtypes ...
Zunsong Hu, Zhilian Jia, Jiangyue Liu, Allen Mao, Helen Han, Zhaohui Gu   +5 more
doaj   +1 more source

PAX5 and TDT-Negative B-Acute Lymphoblastic Leukemia with Unusual Genetic Mutations: A Case Report

Avicenna Journal of Medicine, 2022
B-acute lymphoblastic leukemia (B-ALL) is commonly encountered in clinical practice. Patients present with increased percentage of lymphoblasts in bone marrow and/or peripheral blood.
Tariq N. Aladily, Jamil F. Qiqieh, Alaa Alshorman, Salem Alhyari, Majd Khader   +4 more
doaj   +1 more source

Unexpected Mediastinal Mass Etiology in B-Acute Lymphoblastic Leukemia [PDF]

Journal of Immunotherapy and Precision Oncology
Leukemic masses are a known complication in patients with hematologic malignancies. Here we present a case regarding a patient with recently diagnosed B-acute lymphoblastic leukemia (B-ALL) who presented with multiple sites of extramedullary involvement ...
Luan Phan, Elias Jabbour, Mara B. Antonoff, Nitin Jain, Pei Lin, Cesar Moran, Naveen Pemmaraju   +6 more
doaj   +1 more source

The role of CD58 and CD38 in evaluation of minimal residual disease in childhood B-acute lymphoblastic leukemia [PDF]

Zagazig University Medical Journal, 2022
Background: Measurement of minimal residual disease (MRD) reflects the overall response to therapy, and could be used to refine the treatment of acute lymphoblastic leukemia (ALL). MRD studies by flowcytometry rely on panels of antibodies (Abs) to define
Ahmed Ahmed, Maha Atfy, Tamer Hasan Hassan, Ahmed Baraka, Mervat Azab, Eman Abdel Aziz   +5 more
doaj   +1 more source

Gene copy number alterations in Indian children with B-acute Lymphoblastic Leukemia: Correlation with survival outcome

Pediatric Hematology Oncology Journal, 2021
Background: Acute Lymphoblastic Leukemia (ALL) is the most common lymphoid malignancy occurring in children. Copy number alterations like CDKN2A/B, IKZF1, ETV6, RB1 and BTG1 gene deletions have been shown to be associated with differential survival ...
M. Agarwal, R. Shukla, S.N. Dwivedi, R. Saxena, K. Luthra, M. Kabra, Rachna Seth   +6 more
doaj   +1 more source

Impact of CD105 Flow-Cytometric Expression on Childhood B-Acute Lymphoblastic Leukemia

Journal of Blood Medicine, 2021
Rasha A Elkholy,1 Mohamed H Fouda,1 Eslam E Elhawary,2 Reem A Elkholy,3 Ola A Elshora1 1Clinical Pathology Department, Faculty of Medicine, Tanta University, Tanta, Egypt; 2Pediatrics Department, Faculty of Medicine, Tanta University, Tanta, Egypt ...
Elkholy RA, Fouda MH, Elhawary EE, Elkholy RA, Elshora OA   +4 more
doaj  

Regulome analysis in B-acute lymphoblastic leukemia exposes Core Binding Factor addiction as a therapeutic vulnerability

Nature Communications, 2022
The ETV6-RUNX1 chimeric- and native RUNX1-responsive regulomes in paediatric B-acute lymphoblastic leukemia (B-ALL) remain to be characterized. Here, the authors reveal functional antagonism between the two transcription factors predominantly for the ...
Jason P. Wray, Elitza M. Deltcheva, Charlotta Boiers, Simon Е Richardson, Jyoti Bikram Chhetri, John Brown, Sladjana Gagrica, Yanping Guo, Anuradha Illendula, Joost H. A. Martens, Hendrik G. Stunnenberg, John H. Bushweller, Rachael Nimmo, Tariq Enver   +13 more
doaj   +1 more source

An Adult Patient with Systemic Mastocytosis and B-Acute Lymphoblastic Leukemia

Case Reports in Medicine, 2014
Mastocytosis is a myeloproliferative neoplasm characterized by clonal expansion of abnormal mast cells, ranging from the cutaneous forms of the disease to mast cell leukemia.
Theodoros Iliakis, Niki Rougkala, Panagiotis T. Diamantopoulos, Vasiliki Papadopoulou, Fani Kalala, Konstantinos Zervakis, Nefeli Giannakopoulou, Polixeni Chatzinikolaou, Georgia Levidou, Eleftheria Lakiotaki, Penelope Korkolopoulou, Efstratios Patsouris, Eleni Variami, Nora-Athina Viniou   +13 more
doaj   +1 more source

Pediatric B-Acute lymphoblastic leukemia with ETV6-RUNX1 rearrangment and eosinophilic globular cytoplasmic inclusions – Report and review of literature

Pediatric Hematology Oncology Journal, 2021
B-Acute lymphoblastic leukemia (B-ALL) with intracytoplasmic inclusions in lymphoblasts is an unusual presentation. Here, we present a pediatric case of B-ALL with ETV6-RUNX1 rearrangment and unusual blast morphology showing distinct intracytoplasmic ...
Riju Rani Deka, Shano Naseem, Amita Trehan, Neelam Varma, Jasmina Ahluwalia   +4 more
doaj   +1 more source

Chimeric Antigen Receptor T-Cells in B-Acute Lymphoblastic Leukemia: State of the Art and Future Directions

Frontiers in Oncology, 2020
Use of adoptive T-cell therapy modified with chimeric antigen receptor (CAR-T) has revolutionized treatment of patients with relapsed/refractory (r/r) B-cell acute lymphoblastic leukemia (B-ALL).
Uri Greenbaum, Kris Michael Mahadeo, Partow Kebriaei, Elizabeth J. Shpall, Neeraj Y. Saini   +4 more
doaj   +1 more source