Results 31 to 40 of about 33,886 (209)

Interplay of BAF and MLL4 promotes cell type-specific enhancer activation

Nature Communications, 2021
The SWI/SNF complex BAF and the histone H3K4 methyltransferase MLL4 (KMT2D) play critical roles in enhancer activation, however the interplay between them has remained unclear.
Young-Kwon Park, Ji-Eun Lee, Zhijiang Yan, Kaitlin McKernan, Tommy O’Haren, Weidong Wang, Weiqun Peng, Kai Ge   +7 more
doaj   +1 more source

Chromatin-Remodeling Components of the BAF Complex Facilitate Reprogramming [PDF]

Cell, 2010
Reprogramming of somatic cells achieved by combination of the four transcription factors Oct4, Sox2, Klf4, and c-Myc has very low efficiency. To increase the reprogramming efficiency and better understand the process, we sought to identify factors that mediate reprogramming with higher efficiency.
Singhal, N., Graumann, J., Wu, G., Arauzo-Bravo, M., Han, D., Greber, B., Gentile, L., Mann, M., Schöler, H.   +8 more
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Identification of H3K4me1-associated proteins at mammalian enhancers. [PDF]

, 2017
Enhancers act to regulate cell-type-specific gene expression by facilitating the transcription of target genes. In mammalian cells, active or primed enhancers are commonly marked by monomethylation of histone H3 at lysine 4 (H3K4me1) in a cell-type ...
Albuquerque, Claudio P, Corbett, Kevin D, Ge, Kai, Hsia, Judy E, Huang, Hui, Lee, Ah Young, Local, Andrea, Ren, Bing, Shiau, Andrew K, Singh, Namit, Wang, Chaochen, Wang, Dong, Wang, Wei, Zhou, Huilin   +13 more
core   +2 more sources

BAF complexes facilitate decatenation of DNA by topoisomerase IIα [PDF]

Nature, 2013
Recent exon-sequencing studies of human tumours have revealed that subunits of BAF (mammalian SWI/SNF) complexes are mutated in more than 20% of all human malignancies, but the mechanisms involved in tumour suppression are unclear. BAF chromatin-remodelling complexes are polymorphic assemblies that use energy provided by ATP hydrolysis to regulate ...
Emily C, Dykhuizen, Diana C, Hargreaves, Erik L, Miller, Kairong, Cui, Andrey, Korshunov, Marcel, Kool, Stefan, Pfister, Yoon-Jae, Cho, Keji, Zhao, Gerald R, Crabtree   +9 more
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Conditional Loss of BAF (mSWI/SNF) Scaffolding Subunits Affects Specification and Proliferation of Oligodendrocyte Precursors in Developing Mouse Forebrain

Frontiers in Cell and Developmental Biology, 2021
Oligodendrocytes are responsible for axon myelination in the brain and spinal cord. Generation of oligodendrocytes entails highly regulated multistage neurodevelopmental events, including proliferation, differentiation and maturation.
Eman Abbas, Eman Abbas, Eman Abbas, Mohamed A. Hassan, Godwin Sokpor, Godwin Sokpor, Kamila Kiszka, Linh Pham, Linh Pham, Cemil Kerimoglu, Andre Fischer, Andre Fischer, Andre Fischer, Huu Phuc Nguyen, Jochen F. Staiger, Tran Tuoc, Tran Tuoc   +16 more
doaj   +1 more source

myomiR-dependent switching of BAF60 variant incorporation into Brg1 chromatin remodeling complexes during embryo myogenesis [PDF]

, 2014
Myogenesis involves the stable commitment of progenitor cells followed by the execution of myogenic differentiation, processes that are coordinated by myogenic regulatory factors, microRNAs and BAF chromatin remodeling complexes.
Bajard, Bartel, Buckingham, Béthune, Chen, Chen, Darnell, de la Serna, de la Serna, Ebert, Forcales, Goljanek-Whysall, Goljanek-Whysall, Goljanek-Whysall, Gros, Hamburger, Hirai, Ho, Hornstein, Ivey, Kadam, Krützfeldt, Lamba, Lessard, Lickert, Liu, Liu, Loeb, Mallappa, Mann, McCarthy, McGlinn, Mishima, Mok, Ochi, Puri, Rao, Rosenberg, Saccone, Simone, Sohni, Stark, Sweetman, Sweetman, Takeuchi, van Rooij, Wang, Williams, Williams, Wu, Yoo, Yoo, Zhao   +52 more
core   +1 more source

The BAF complex and HIV latency [PDF]

Transcription, 2012
The persistence of a reservoir of transcriptionally competent but latent virus in the presence of antiviral regimens presents the main impediment to a curative therapy against HIV. Therefore it is critical to understand the molecular mechanisms, which lead to the establishment and maintenance of HIV latency, and which contribute to the reversal of this
openaire   +3 more sources

BAF chromatin remodeling complex: Cortical size regulation and beyond [PDF]

Cell Cycle, 2013
The multi-subunit chromatin remodeling BAF complex controls different developmental processes. Using cortex-specific conditional knockout and overexpression mouse models, we have recently reported that BAF170, a subunit of the vertebrate BAF chromatin remodeling complex, interacts with transcription factor (TF) Pax6 to control cortical size and volume.
Tuoc, T., Narayanan, R., Stoykova, A.
openaire   +4 more sources

Calcium release through P2X4 activates calmodulin to promote endolysosomal membrane fusion [PDF]

, 2015
Intra-endolysosomal Ca(2+) release is required for endolysosomal membrane fusion with intracellular organelles. However, the molecular mechanisms for intra-endolysosomal Ca(2+) release and the downstream Ca(2+) targets involved in the fusion remain ...
Baars, Bakker, Brandhorst, Calcraft, Cang, Cao, Chen, Cheng, Christensen, Clarke, Coddou, Colombo, Cong, Dong, Dong, Dong, Efe, Graves, Grimm, Guo, Hay, Huang, Huynh, Khakh, Lange, Lin-Moshier, Lloyd-Evans, Luzio, Luzio, Martinez, Michael X. Zhu, Miklavc, Moreau, Morgan, Nielsen, Ogunbayo, Parkinson, Peri, Peters, Piper, Pittman, Poole, Pryor, Qi Cao, Quetglas, Qureshi, Rong, Ruas, Rudge, Ruth Murrell-Lagnado, Saftig, Samie, Schieder, Shen, Shen, Silberberg, Stoop, Sumoza-Toledo, Tapper, Treusch, Tsuboi, van den Berghe, Vergarajauregui, Wang, Ward, Weinert, Xi Zoë Zhong, Xia, Xian-Ping Dong, Yuanjie Zou, Zhao   +70 more
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SWI/SNF (BAF) Complexes: Guardians of the Epigenome [PDF]

Annual Review of Cancer Biology, 2018
The genomics-era search for cancer-causing mutations has identified subunits of SWI/SNF (BAF) chromatin remodeling complexes as major targets of mutation. The mechanism by which mutations in SWI/SNF complexes might drive cancer has become the subject of debate, as these complexes have roles in both transcriptional regulation and maintenance of genomic
Radhika Mathur, Charles W.M. Roberts
openaire   +1 more source