Results 21 to 30 of about 33,886 (209)

Spliceosomal disruption of the non-canonical BAF complex in cancer. [PDF]

Nature, 2019
SF3B1 is the most commonly mutated RNA splicing factor in cancer1-4, but the mechanisms by which SF3B1 mutations promote malignancy are poorly understood. Here we integrated pan-cancer splicing analyses with a positive-enrichment CRISPR screen to prioritize splicing alterations that promote tumorigenesis. We report that diverse SF3B1 mutations converge
Inoue D, Chew GL, Liu B, Michel BC, Pangallo J, D'Avino AR, Hitchman T, North K, Lee SC, Bitner L, Block A, Moore AR, Yoshimi A, Escobar-Hoyos L, Cho H, Penson A, Lu SX, Taylor J, Chen Y, Kadoch C, Abdel-Wahab O, Bradley RK.   +21 more
europepmc   +4 more sources

Altered BAF occupancy and transcription factor dynamics in PBAF-deficient melanoma

Cell Reports, 2022
Summary: ARID2 is the most recurrently mutated SWI/SNF complex member in melanoma; however, its tumor-suppressive mechanisms in the context of the chromatin landscape remain to be elucidated.
Saul Carcamo, Christie B. Nguyen, Elena Grossi, Dan Filipescu, Aktan Alpsoy, Alisha Dhiman, Dan Sun, Sonali Narang, Jochen Imig, Tiphaine C. Martin, Ramon Parsons, Iannis Aifantis, Aristotelis Tsirigos, Julio A. Aguirre-Ghiso, Emily C. Dykhuizen, Dan Hasson, Emily Bernstein   +16 more
doaj   +1 more source

Degradation of the BAF Complex Factor BRD9 by Heterobifunctional Ligands. [PDF]

Angew Chem Int Ed Engl, 2017
AbstractThe bromodomain‐containing protein BRD9, a subunit of the human BAF (SWI/SNF) nucleosome remodeling complex, has emerged as an attractive therapeutic target in cancer. Despite the development of chemical probes targeting the BRD9 bromodomain, there is a limited understanding of BRD9 function beyond acetyl‐lysine recognition.
Remillard D, Buckley DL, Paulk J, Brien GL, Sonnett M, Seo HS, Dastjerdi S, Wühr M, Dhe-Paganon S, Armstrong SA, Bradner JE.   +10 more
europepmc   +4 more sources

The BAF chromatin remodeling complex licenses planarian stem cells access to ectodermal and mesodermal cell fates

BMC Biology, 2023
Background The flatworm planarian, Schmidtea mediterranea, has a large population of adult stem cells (ASCs) that replace any cell type during tissue turnover or regeneration.
Mallory Wiggans, Shu Jun Zhu, Alyssa M. Molinaro, Bret J. Pearson   +3 more
doaj   +1 more source

Mammalian SWI/SNF Chromatin Remodeling Complexes in Embryonic Stem Cells: Regulating the Balance Between Pluripotency and Differentiation

Frontiers in Cell and Developmental Biology, 2021
The unique capability of embryonic stem cells (ESCs) to maintain and adjust the equilibrium between self-renewal and multi-lineage cellular differentiation contributes indispensably to the integrity of all developmental processes, leading to the advent ...
Ying Ye, Xi Chen, Wensheng Zhang
doaj   +1 more source

Language Impairments in Individuals With Coffin-Siris Syndrome

Frontiers in Neuroscience, 2022
Coffin-Siris syndrome (CSS, MIM 135900) is a now well-described, multiple congenital anomaly/intellectual disability syndrome classically characterized by fifth digit/nail hypoplasia, coarse facial features, and a range of organ-system related anomalies.
Ashley Vasko, Samantha A. Schrier Vergano, Samantha A. Schrier Vergano   +2 more
doaj   +1 more source

The BAF chromatin remodelling complex is an epigenetic regulator of lineage specification in the early mouse embryo. [PDF]

, 2016
Dynamic control of gene expression is essential for the development of a totipotent zygote into an embryo with defined cell lineages. The accessibility of genes responsible for cell specification to transcriptional machinery is dependent on chromatin ...
Bulgakova, Natalia, Butler, Richard, Cox, Andy, Crabtree, Gerald, Jeon, Shin, Panamarova, Maryna, Rosen, Barry, Seong, Rho H, Skarnes, William, Wicher, Krzysztof B, Zernicka-Goetz, Magdalena   +10 more
core   +10 more sources

BAFfling pathologies: Alterations of BAF complexes in cancer [PDF]

Cancer Letters, 2018
To activate or repress specific genes, chromatin is constantly modified by chromatin-remodeling complexes. Among these complexes, the SWItch/Sucrose Non-Fermenting (SWI/SNF) complex, also referred to as BRG1-Associated Factor (BAF) complex, moves the nucleosome along chromatin using energy provided by ATP hydrolysis. In mammalian organisms, the SWI/SNF
Arnaud, Ophélie, Le Loarer, Francois, Tirode, Franck   +2 more
openaire   +2 more sources

SS18 regulates pluripotent-somatic transition through phase separation

Nature Communications, 2021
Emerging evidence suggests that exit from pluripotency is a regulated, rather than passive process. Here the authors identify a requirement for SS18-mediated Brg/Brahma-associated factors (BAF) chromatin remodeling complex assembly during exit from ...
Junqi Kuang, Ziwei Zhai, Pengli Li, Ruona Shi, Wenjing Guo, Yuxiang Yao, Jing Guo, Guoqing Zhao, Jiangpin He, Shuyang Xu, Chuman Wu, Shengyong Yu, Chunhua Zhou, Linlin Wu, Yue Qin, Baomei Cai, Wei Li, Zichao Wu, Xiaoxi Li, Shilong Chu, Tingting Yang, Bo Wang, Shangtao Cao, Dongwei Li, Xiaofei Zhang, Jiekai Chen, Jing Liu, Duanqing Pei   +27 more
doaj   +1 more source

BAF complexes and the glucocorticoid receptor in breast cancers

Current Opinion in Endocrine and Metabolic Research, 2020
Breast cancers are a diverse group of diseases and are often characterized by their expression of receptors for hormones such as estrogen and progesterone. Recently another steroid hormone receptor, the glucocorticoid receptor (GR) has been shown to be a key player in breast cancer progression, metastasis, and treatment.
Nicholas Dietrich, Jackson A. Hoffman, Trevor K. Archer   +2 more
openaire   +3 more sources