Loss of BAF Complex in Developing Cortex Perturbs Radial Neuronal Migration in a WNT Signaling-Dependent Manner [PDF]
Frontiers in Molecular Neuroscience, 2021 Radial neuronal migration is a key neurodevelopmental event indispensable for proper cortical laminar organization. Cortical neurons mainly use glial fiber guides, cell adhesion dynamics, and cytoskeletal remodeling, among other discrete processes, to ...
Godwin Sokpor +17 more
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YY1 Positively Regulates Transcription by Targeting Promoters and Super-Enhancers through the BAF Complex in Embryonic Stem Cells [PDF]
Stem Cell Reports, 2018 Summary: Yin Yang 1 (YY1) regulates early embryogenesis and adult tissue formation. However, the role of YY1 in stem cell regulation remains unclear. YY1 has a Polycomb group (PcG) protein-dependent role in mammalian cells.
Jia Wang +21 more
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Tissue-specific co-expression patterns of BAF complex genes across human endocrine and non-endocrine tissues [PDF]
Endocrine ConnectionsBRG1/BRM-associated factor (BAF) chromatin remodeling complexes are essential for normal endocrine function and are implicated in various metabolic and developmental disorders.
Xiaowei Dong +3 more
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The BAF complex in development and disease [PDF]
Epigenetics & Chromatin, 2019 The ATP-dependent chromatin remodelling complex BAF (= mammalian SWI/SNF complex) is crucial for the regulation of gene expression and differentiation. In the course of evolution from yeast to mammals, the BAF complex evolved an immense complexity with a
Amelie Alfert +2 more
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BAF (mSWI/SNF) complex regulates mediolateral cortical patterning in the developing forebrain
Frontiers in Cell and Developmental Biology, 2022 Early forebrain patterning entails the correct regional designation of the neuroepithelium, and appropriate specification, generation, and distribution of neural cells during brain development.
Huong Nguyen +22 more
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BAF Complex in Embryonic Stem Cells and Early Embryonic Development [PDF]
Stem Cells International, 2021 Embryonic stem cells (ESCs) can self-renew indefinitely and maintain their pluripotency status. The pluripotency gene regulatory network is critical in controlling these properties and particularly chromatin remodeling complexes.
Heyao Zhang +4 more
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BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design. [PDF]
Nat Chem Biol, 2019 Targeting subunits of BAF/PBAF chromatin remodeling complexes has been proposed as an approach to exploit cancer vulnerabilities. Here, we develop proteolysis targeting chimera (PROTAC) degraders of the BAF ATPase subunits SMARCA2 and SMARCA4 using a ...
Farnaby W +36 more
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The BAF complex enhances transcription through interaction with H3K56ac in the histone globular domain [PDF]
Nature CommunicationsHistone post-translational modifications play pivotal roles in eukaryotic gene expression. To date, most studies have focused on modifications in unstructured histone N-terminal tail domains and their binding proteins. However, transcriptional regulation
Kwangbeom Hyun +8 more
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Hijacking the BAF complex: the mechanistic interplay of ARID1A and EWS::FLI1 in Ewing sarcoma [PDF]
Molecular OncologyEwing sarcoma, an aggressive pediatric cancer, is driven by the EWS::FLI1 fusion protein, which disrupts gene expression by hijacking the BAF chromatin remodeling complex.
Erich J. Sohn, David S. Libich
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Structural Insights into the Evolutionarily Conserved BAF Chromatin Remodeling Complex
Biology, 2020 The switch/sucrose nonfermentable (SWI/SNF) family of proteins acts to regulate chromatin accessibility and plays an essential role in multiple cellular processes.
Ryan D. Marcum, Alexis A. Reyes, Yuan He
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