Synthesis and Biochemical Evaluation of Baicalein Prodrugs [PDF]
Pharmaceutics, 2021 Baicalein (5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one), a flavonoid analog from Scutellaria baicalensis, possesses several pharmacological activities including antioxidant, antiproliferative, and anti-inflammatory activities.
Sang-Hyun Son +8 more
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Baicalein induces apoptosis by inhibiting the glutamine-mTOR metabolic pathway in lung cancer
Journal of Advanced ResearchIntroduction: Baicalein, a bioactive component of Scutellaria baicalensis Georgi, has been shown to promote apoptosis in non-small cell lung cancer cells.
Shaohui Wang, Xianli Meng
exaly +3 more sources
Baicalein Enhances Longevity and Healthspan of C. elegans Through the Insulin/IGF‐1 Signaling Pathway [PDF]
MedCommBaicalein, a bioactive flavonoid derived from Scutellaria baicalensis, possesses notable anti‐inflammatory, antioxidative, and anticancer properties. Despite its therapeutic potential, the full scope of its effects on healthspan and longevity remains ...
Chen Zhao +2 more
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Calcium-dependent serine-threonine phosphatase and autophagy inactivation mediated by Baicalein attenuates prion protein-mediated neuronal cell damage [PDF]
BMC Complementary Medicine and TherapiesBackground Prion diseases are a group of incurable and fatal neurodegenerative disorders characterized by neuronal cell death. Calcineurin and autophagy induce neurotoxicity by prion proteins, which may have therapeutic benefits by inhibiting calcineurin
Jeong-Min Hong +5 more
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Frontiers in Immunology, 2023 Pancreatic ductal adenocarcinoma (PDAC) is one of the most malignant and lethal human cancers in the world due to its high metastatic potential, and patients with PDAC have a poor prognosis, yet quite little is understood regarding the underlying ...
Citing Zhang +10 more
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Baicalein Potentiated M1 Macrophage Polarization in Cancer Through Targeting PI3Kγ/ NF-κB Signaling
Frontiers in Pharmacology, 2021 Baicalein is one of the bioactive compounds extracted from Scutellaria baicalensis. Recent studies indicated the antitumor effects of baicalein, however, the underlying mechanisms are needed to be further determined.
Shan He +5 more
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Frontiers in Neurology, 2022 Parkinson's disease (PD) is a prevailing neurodegenerative disorder. Baicalein has neuroprotective effects on PD animals, but its mechanism is not clarified. We explored baicalein effects on PD rats.
Min Chen +6 more
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Inhibition of Autophagy Amplifies Baicalein-Induced Apoptosis in Human Colorectal Cancer
Molecular Therapy: Oncolytics, 2020 Baicalein is a Chinese herbal compound extracted from Scutellaria baicalensis that has anti-tumor properties. The aim of this study was to elucidate the mechanisms of action of baicalein against human colorectal cancer cell lines and to assess whether ...
Thuy Phan +6 more
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Pharmaceutical Biology, 2023 Context Fibroblast senescence was reported to contribute to the pathological development of idiopathic pulmonary fibrosis (IPF), and baicalein is reported to attenuate IPF.Objective This study explores whether baicalein attenuates lung fibrosis by ...
Yuan Ji-hong +6 more
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Baicalein inhibits the invasion and metastatic capabilities of hepatocellular carcinoma cells via down-regulation of the ERK pathway. [PDF]
PLoS ONE, 2013 Baicalein, a widely used Chinese herbal medicine, has historically been used in anti-inflammatory and anti-cancer therapies. However, the anti-metastatic effect and molecular mechanism(s) of baicalein on hepatocellular carcinoma (HCC) remain poorly ...
Kunlun Chen +8 more
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