Results 31 to 40 of about 9,962 (180)

Baicalein Inhibits MMPs Expression via a MAPK-Dependent Mechanism in Chondrocytes

Cellular Physiology and Biochemistry, 2015
Background: Baicalein is a flavonoid isolated from Scutellaria baicalensis Georgi. Here, we investigated the anti-osteoarthritic effect of baicalein in vitro and in vivo.
Wei-Ping Chen, Yan Xiong, Peng-Fei Hu, Jia-Peng Bao, Li-Dong Wu   +4 more
doaj   +1 more source

Therapeutic mechanism of baicalein in peritoneal dialysis-associated peritoneal fibrosis based on network pharmacology and experimental validation

Frontiers in Pharmacology, 2023
Baicalein (5,6,7-trihydroxyflavone) is a traditional Chinese medicine with multiple pharmacological and biological activities including anti-inflammatory and anti-fibrotic effects.
Xiaohui Lu, Xiaohui Lu, Kefei Wu, Kefei Wu, Simin Jiang, Simin Jiang, Yi Li, Yi Li, Yating Wang, Yating Wang, Hongyu Li, Hongyu Li, Guanglan Li, Guanglan Li, Qinghua Liu, Qinghua Liu, Yi Zhou, Yi Zhou, Wei Chen, Wei Chen, Haiping Mao, Haiping Mao   +21 more
doaj   +1 more source

Baicalein as a potent neuroprotective agent: A review

Biomedicine & Pharmacotherapy, 2017
In recent times, neurodegenerative diseases are the most challenging global health problems. Neuronal cell death or damage is a key factor for many neurodegenerative disorders. Therefore, there has been a growing interest in the development of effective neuroprotective agents, especially from natural sources.
Kandhasamy, Sowndhararajan, Ponnuvel, Deepa, Minju, Kim, Se Jin, Park, Songmun, Kim   +4 more
openaire   +2 more sources

Baicalein as a potent antifungal agent against Candida albicans: synergy with fluconazole and sustainable production through probiotic-mediated bioconversion

Frontiers in Microbiology
Fungal infections, particularly those caused by Candida albicans, represent a significant global health concern, with drug resistance and biofilm formation posing considerable challenges to effective treatment.
Hang Zhai, Jialing Zeng, Xiaonan Ma, Fuju Wang, Wei Xu, Ming Song, Weizhuo Xu   +6 more
doaj   +1 more source

Light‐Controlled Modulation of 15‐Lipoxygenase‐1 Regulates Intestinal Inflammatory Signaling

Angewandte Chemie International Edition, EarlyView.
The developed target‐guided strategy enables the rational design of diazo‐based photoswitchable inhibitors of 15‐lipoxygenase‐1. Distinct molecular architectures program opposite light‐dependent activity, allowing on‐demand control of enzyme inhibition.
Anastasia Louka, Eirini‐Eleni Kalaitzaki, Athanasios Panousis, Sotirios Bonoras, Charalampos Livas, George Froudakis, Ioannis Drygiannakis, Athina Damianaki, George Kolios, Vassilis Valatas, Nikolaos Eleftheriadis   +10 more
wiley   +1 more source

Targeting eEF1A1 With Baicalein to Block eEF1A1/Prdx4 Interaction for Treating Sepsis‐Mediated Lung Injury

Exploration, EarlyView.
Targeting eEF1A1 with baicalein disrupts the eEF1A1‐Prdx4 interaction to prevent RNF14‐mediated ubiquitination and degradation of Prdx4. This stabilizes Prdx4 to suppress NF‐κB, thereby alleviating sepsis‐induced acute lung injury. ABSTRACT Sepsis is a systemic inflammatory response syndrome triggered by an uncontrolled host response to infection ...
Jing Chang, Hui‐Lin Zhang, Qi‐Meng Zhu, Si‐Wen Hui, Xin‐Rong Xu, Mahmood Brobbey Oppong, Yan‐Li Feng, Juan Zhang, Cheng‐Peng Sun, Feng Qiu   +9 more
wiley   +1 more source

Baicalein inhibits progression of gallbladder cancer cells by downregulating ZFX. [PDF]

PLoS ONE, 2015
Baicalein, a widely used Chinese herbal medicine, has multiple pharmacological activities. However, the precise mechanisms of the anti-proliferation and anti-metastatic effects of baicalein on gallbladder cancer (GBC) remain poorly understood. Therefore,
Tian-Yu Liu, Wei Gong, Zhu-Jun Tan, Wei Lu, Xiang-Song Wu, Hao Weng, Qian Ding, Yi-Jun Shu, Run-Fa Bao, Yang Cao, Xu-An Wang, Fei Zhang, Huai-Feng Li, Shan-Shan Xiang, Lin Jiang, Yun-Ping Hu, Jia-Sheng Mu, Mao-Lan Li, Wen-Guang Wu, Bai-Yong Shen, Li-Xin Jiang, Ying-Bin Liu   +21 more
doaj   +1 more source

Plant‐Derived Extracts Disrupt Biofilm Formation and Quorum Sensing in Yersinia enterocolitica: Insights From GC‐MS and Molecular Docking

Food Chemistry International, EarlyView.
The graphical abstract represents how natural plant products that preferentially target the specific receptors of quorum sensing could be developed to combat biofilms linked to Yersinia enterocolitica using the potent abilities of protein–ligand complexes with high docking scores.
Rajendran Thomas, Songeeta Singha, Devarshi Bharadwaj, Abinash Kumar, Dolly Sharma, Sadhana Ojha, Hirakjyoti Das, Vivek Kumar Gupta   +7 more
wiley   +1 more source

Polydatin Alleviates APAP‐Induced Hepatotoxicity by Targeting C/EBPβ to Suppress the NLRP3 Inflammasome Signaling Pathway

iNew Medicine, EarlyView.
PD alleviates APAP‐induced ALI by inhibiting the NLRP3 inflammasome signaling pathway. C/EBPβ is identified as a direct target via multimethod validation. PD promotes the deacetylation of C/EBPβ via Sirt1. The Sirt1/C/EBPβ/NLRP3 signaling axis is defined for PD's hepatoprotective effect.
Tian‐Yu Yang, Chen Wang, Yi Ding, Wei‐Kang Zhang, Ling Zheng, Li Yue, Lei Zhang   +6 more
wiley   +1 more source

Kaempferol Attenuates Myocardial Ischemia–Reperfusion Injury by Suppressing Ferroptosis via the KEAP1–Nrf2–GPX4 Axis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Myocardial ischemia/reperfusion (I/R) injury is characterized by cardiomyocyte death, excessive oxidative stress, inflammation, and ferroptosis, which collectively limit the efficacy of reperfusion therapy. In this study, we investigated whether kaempferol (KAE), a natural flavonol with antioxidative and antiinflammatory properties, could ...
Yan‐Bo Zhao, Ling‐Ling Sun, Xiao‐Hua Shen, Min Wang, Mei‐Hui Wang, Lu‐Lu Liu, Kai Zhang   +6 more
wiley   +1 more source