Results 51 to 60 of about 9,962 (180)

Baicalein, a Bioflavonoid, Prevents Cisplatin-Induced Acute Kidney Injury by Up-Regulating Antioxidant Defenses and Down-Regulating the MAPKs and NF-κB Pathways. [PDF]

PLoS ONE, 2015
Acute renal failure is a serious complication of the anticancer drug cisplatin. The potential role of baicalein, a naturally occurring bioflavonoid on cisplatin-induced renal injury is unknown.
Bidya Dhar Sahu, Jerald Mahesh Kumar, Ramakrishna Sistla   +2 more
doaj   +1 more source

Baicalein Exerts Therapeutic Effects against Endotoxin-Induced Depression-like Behavior in Mice by Decreasing Inflammatory Cytokines and Increasing Brain-Derived Neurotrophic Factor Levels

Antioxidants, 2022
Inflammation plays an important role in the pathophysiology of depression. This study aims to elucidate the antidepressant effect of baicalein, an anti-inflammatory component of a traditional Chinese herbal medicine (Scutellaria baicalensis), on ...
Hsin-Tzu Liu, Yu-Ning Lin, Ming-Cheng Tsai, Ya-Chi Wu, Ming-Chung Lee   +4 more
doaj   +1 more source

Application of Baicalein Solution as a Novel Antioxidant After Bleaching: Analysis of Its Effects on Immediate Color Stability and the Reestablishment of Bond Strength in Bleached Enamel

Journal of Esthetic and Restorative Dentistry, EarlyView.
ABSTRACT Objective To evaluate the antioxidant capacity of the baicalein solution (BA), as well as its effect when applied for different times to the surface of bleached dental enamel, considering immediate color stability and bond strength. Materials and Methods Bovine enamel/dentin specimens (4 × 4 × 3 mm) were randomly divided into five groups (n ...
Herica Myllena Correia da Silva, Weslley Felipe Pin, Marina Rodrigues Santi, Beatriz Ometto Sahadi, Luís Roberto Marcondes Martins   +4 more
wiley   +1 more source

Natural Compounds Targeting Oncogenic Signaling Networks in Glioblastoma: Molecular Mechanisms, Translational Advances, and Clinical Perspectives

Brain and Behavior, Volume 16, Issue 9, September 2026.
Glioblastoma (GBM) is a highly aggressive brain tumor with a poor prognosis, driven by abnormal signaling pathways that promote growth and resistance to treatment. Conventional therapies are inadequate, highlighting the need for novel multitargeted approaches.
Mehrukh Zehravi, Md Abul Hassan, Md. Al Amin, Sherouk Hussein Sweilam, Jeetendra Kumar Gupta, Ramenani Hari Babu, Pericharla Venkata Narasimha Raju, Krishna Vamsi Kandimalla, Phanindra Erukulla, Patibandla Jahnavi, Rajeshwar Vodeti, Abdul Ajeed Mohathasim Billah, Safia Obaidur Rab, Sharuk L. Khan   +13 more
wiley   +1 more source

Synthesis of Heterocyclic Baicalein Derivatives

Bulletin of the Korean Chemical Society, 2013
Flavonoids are widely distributed in plant kingdom and they belong to the secondary metabolites of plants. Their diverse structures (Figure 1) combined with variety of biological activities such as anti-cancer, anti-inflammatory, anti-viral, apoptosis and anti-oxidation drew much attention during last decades. The importance of Baicalein derivatives in
Ki-Jun Hwang, Kwang-Jin Cho, Beom-Tae Kim   +2 more
openaire   +2 more sources

The Effects of Baicalin and Baicalein on Cerebral Ischemia: A Review [PDF]

Aging and disease, 2017
Ischemic stroke, producing a high mortality and morbidity rate, is a common clinical disease. Enhancing the prevention and control of ischemic stroke is particularly important. Baicalin and its aglycon baicalein are flavonoids extracted from Scutellaria baicalensis, an important traditional Chinese herb. In recent years, a growing body of evidences has
Liang, Wei, Huang, Xiaobo, Chen, Wenqiang   +2 more
openaire   +2 more sources

Baicalein Inhibits Stx1 and 2 of EHE: Effects of Baicalein on the Cytotoxicity, Production, and Secretion of Shiga Toxins of Enterohaemorrhagic Escherichia coli

Toxins, 2019
Shiga toxin-producing enterohaemorrhagic Escherichia coli (EHEC) O157:H7 is an important foodborne pathogen. Baicalein (5,6,7-trihydroxylflavone), a flavone isolated from the roots of Scutellaria baicalensis, is considered as a potential antibacterial ...
Pham Thi Vinh, Yui Shinohara, Akifumi Yamada, Hoang Minh Duc, Motokazu Nakayama, Tadahiro Ozawa, Jun Sato, Yoshimitsu Masuda, Ken-Ichi Honjoh, Takahisa Miyamoto   +9 more
doaj   +1 more source

Induction of DNMT1-dependent demethylation of SHP-1 by the natural flavonoid compound Baicalein overcame Imatinib-resistance in CML CD34+ cells

Cell Communication and Signaling, 2023
Background The most significant cause of treatment failure in chronic myeloid leukemia (CML) is a persistent population of minimal residual cells. Emerging evidences showed that methylation of SHP-1 contributed to Imatinib (IM) resistance.
Xuefen Xu, Shufan Ji, Yuan Chen, Siwei Xia, Yang Li, Li Chen, Yujia Li, Feng Zhang, Zili Zhang, Shizhong Zheng   +9 more
doaj   +1 more source

Mitochondria as the Hub of Apoptosis: A Comprehensive Insight From Mitochondria to Interactions With Other Organelles

MedComm, Volume 7, Issue 9, September 2026.
Mitochondria is the hub of apoptosis in various diseases. The disruption of mitochondrial structure (including membrane rupture, cristae remodeling, and mitochondrial membrane lipid redistribution), the imbalance of mitochondrial dynamics (including fusion and fission, autophagy), the release, disruption, and mutation of mitochondria DNA, as well as ...
Rubin Tan, Jinming Zhao, Rong Wang, Yue Shi, Zaozao Chen, Yixuan Ma, Na Li, Wenqing Duan, Duo Lin, Chunxiang Zhang   +9 more
wiley   +1 more source

Investigation of the mechanism of baicalein in the treatment of periodontitis based on network pharmacology, molecular docking and experimental validation

BMC Oral Health
Purpose To verify the effect and mechanism of baicalein in the treatment of periodontitis through network pharmacology, molecular docking and in vitro experiments.
Yue Liu, Fengdi Cao, Mingyue Shi, Zhuohang Deng, Kaili Guo, Tiantian Fan, Yuhan Meng, Mingyang Bu, Zhe Ma   +8 more
doaj   +1 more source