Results 11 to 20 of about 9,962 (180)

The interaction between cucurbit[8]uril and baicalein and the effect on baicalein properties [PDF]

Beilstein Journal of Organic Chemistry, 2020
The host–guest interactions between baicalein (BALE) and cucurbit[8]uril (Q[8]) and the corresponding properties of the inclusion complex were studied using 1H NMR, IR and UV–vis spectroscopy and DTA. The results showed that BALE forms an inclusion compound (1:1) with Q[8], and the properties of baicalein are changed by cucurbit[8]uril.
Xiaodong Zhang, Jun Xie, Zhiling Xu, Zhu Tao, Qianjun Zhang   +4 more
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Inhibition of microsomal lipid peroxidation by baicalein: A possible formation of an iron‐baicalein complex [PDF]

IUBMB Life, 1996
AbstractBaicalein decreased the production of thiobarbituric acid reactive substances, the rate of oxygen consumption and iron reduction in the reaction system of ascorbic acid with FeCl3. Superoxide dismutase, catalase and hydroxyl radical scavengers had no significant effect. Ironchelators had an inhibitory effect similar to that of baicalein.
D, Gao, K, Sakurai, M, Katoh, J, Chen, T, Ogiso   +4 more
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Beneficial effects of baicalein on a model of allergic rhinitis

Acta Pharmaceutica, 2020
Allergic rhinitis (AR) is a common disease that causes severe inflammation and even disabilities. Previous studies have reported baicalein to have an anti-inflammatory effect.
Liu Tao, Xu Jing, Wu Yungang, Li Xiaoxia, Ding Detao, Ma Dengdian, Yao Mengwei, Wei Wenzhong, Zhang Wei, Wang Shaohua, Yao Jing, Li Xiaoyu   +11 more
doaj   +1 more source

Cell type-specific dependency on the PI3K/Akt signaling pathway for the endogenous Epo and VEGF induction by baicalein in neurons versus astrocytes. [PDF]

PLoS ONE, 2013
The neuroprotective effect of baicalein is generally attributed to inhibition of 12/15-lipoxygenase (12/15-LOX) and suppression of oxidative stress, but recent studies showed that baicalein also activates hypoxia-inducible factor-α (HIF1α) through ...
Yu-Yo Sun, Shang-Hsuan Lin, Hung-Cheng Lin, Chia-Chi Hung, Chen-Yu Wang, Yen-Chu Lin, Kuo-Sheng Hung, Cheng-Chang Lien, Chia-Yi Kuan, Yi-Hsuan Lee   +9 more
doaj   +1 more source

Binding Mechanism and Conformation and Functional Changes of Soybean Protein-Baicalein Complexes [PDF]

Shipin Kexue, 2023
This study aimed to explore the binding mechanism of soybean β-conglycinin (7S)/glycinin (11S) with baicalein, and to investigate the changes in the conformational and functional properties of the complexes.
YAN Xinyue, JIA Yijia, SUN Shiyan, ZHANG Dongmeng, GENG Mengjie, YANG Jinjie, Stanislav Sukhikh, Olga Babich, QI Baokun, LI Yang
doaj   +1 more source

Potential therapeutic effects of baicalin and baicalein.

Avicenna journal of phytomedicine, 2023
Baicalin and baicalein are natural flavonoids reported for the first time from Scutellaria baicalensis Georgi. Recently, attention has been paid to these valuable flavonoids due to their promising effects. This paper aims to have a comprehensive review of their pharmacological effects.An extensive search through scientific databases including Scopus ...
Sabry, Kamyar, Jamshidi, Zahra, Emami, Seyed Ahmad, Sahebkar, Amir Hossein, Akaberi, Maryam   +4 more
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Baicalein facilitates gastric cancer cell apoptosis by triggering endoplasmic reticulum stress via repression of the PI3K/AKT pathway

Applied Biological Chemistry, 2023
Objective Gastric cancer (GC) remains a prevailing threat to life. Baicalein exhibits anti-cancer properties. This study estimated the mechanism of baicalein in GC cell apoptosis by mediating endoplasmic reticulum stress (ERS) through the PI3K/AKT ...
Junjie Shen, Zhiwen Yang, Xinlin Wu, Guodong Yao, Mingxing Hou   +4 more
doaj   +1 more source

Molecular Elucidation of Pancreatic Elastase Inhibition by Baicalein [PDF]

Journal of Biomolecular Structure and Dynamics, 2020
ABSTRACT The serine protease, elastase exists in various forms and plays diverse roles in the human body. Pharmacological inhibition of elastase has been investigated for its therapeutic role in managing conditions such as diabetes, pneumonia and arthritis.
Debajeet Ghosh, Sneha Bansode, Rakesh Joshi, Baban Kolte, Rajesh Gacche   +4 more
openaire   +3 more sources

Baicalein inhibits the pharmacokinetics of simvastatin in rats via regulating the activity of CYP3A4

Pharmaceutical Biology, 2021
Context Baicalein and simvastatin possess similar pharmacological activities and indications. The risk of their co-administration was unclear. Objective The interaction between baicalein and simvastatin was investigated to provide reference and guidance ...
Meng Meng, Xin Li, Xiuwen Zhang, Bin Sun
doaj   +1 more source

Baicalein Inhibits Metastatic Phenotypes in Nasopharyngeal Carcinoma Cells via a Focal Adhesion Protein Integrin β8

Pharmaceuticals, 2021
Baicalein, a prominent flavonoid from the indigenous herbal plant Scutellaria baicalensis Georgi, possesses broad-spectrum anticancer activities. However, the biological effects of baicalein on nasopharyngeal carcinoma (NPC) and its underlying mechanisms
Pichamon Kiatwuthinon, Thana Narkthong, Utapin Ngaokrajang, Supeecha Kumkate, Tavan Janvilisri   +4 more
doaj   +1 more source