Results 61 to 70 of about 20,980 (270)

Dietary Baicalin Supplementation Can Enhance the Growth Performance of Weaned Piglets and Maintain the Intestinal Barrier Integrity

Animal Research and One Health, EarlyView.
This research innovatively illustrates baicalin’s multifaceted mechanisms in enhancing piglets’ intestinal health: modulating bile acid metabolism via probiotics, reinforcing tight junction proteins (ZO‐1/claudin), suppressing TLR4/NF‐κB‐mediated inflammation, whereas promoting growth and reducing diarrhea.
Yuhui Gao, Jie Liu, Rui Yang, Xizhen Fan, Cheng Liang, Xin'e Shi, Jianjun Jin   +6 more
wiley   +1 more source

Baicalin Mitigates Cardiac Hypertrophy and Fibrosis by Inhibiting the p85a Subunit of PI3K

Biomedicines
Background: Heart failure (HF) is a serious public health concern. Baicalin is one of the major active ingredients of a traditional Chinese herbal medicine, Huang Qin, which is used to treat patients with chest pain or cardiac discomfort.
Lu He, Min Zhu, Rui Yin, Liangli Dai, Juan Chen, Jie Zhou   +5 more
doaj   +1 more source

Inhibition of baicalin on metabolism of phenacetin, a probe of CYP1A2, in human liver microsomes and in rats.

PLoS ONE, 2014
Baicalin has been used as mainly bioactive constituent of about 100 kinds of traditional Chinese medicines in Chinese pharmacopoeia. The effect of baicalin on cytochrome P450 should be paid more attention because baicalin was used widely. The aim of this
Na Gao, Bing Qi, Fang-jun Liu, Yan Fang, Jun Zhou, Lin-jing Jia, Hai-ling Qiao   +6 more
doaj   +1 more source

Inspiration for COVID-19 Treatment: Network Analysis and Experimental Validation of Baicalin for Cytokine Storm

Frontiers in Pharmacology, 2022
Background: Cytokine storm (CS) is a systemic inflammatory syndrome and a major cause of multi-organ failure and even death in COVID-19 patients. With the increasing number of COVID-19 patients, there is an urgent need to develop effective therapeutic ...
Jia You, Huawei Li, Peng Fan, Xi Yang, Yuanfeng Wei, Lingnan Zheng, Zhaojun Li, Cheng Yi   +7 more
doaj   +1 more source

Danshen-Chuanxiong-Honghua Ameliorates Cerebral Impairment and Improves Spatial Cognitive Deficits after Transient Focal Ischemia and Identification of Active Compounds. [PDF]

, 2017
Previously, we only apply a traditional Chinese medicine (TCM) Danshen-Chuanxiong-Honghua (DCH) for cardioprotection via anti-inflammation in rats of acute myocardial infarction by occluding coronary artery. Presently, we select not only DCH but also its
Fushun Wang, Jian Wang, Ping Ren, Tingrui Wang, Wan Zheng, Xi Huang, Xi Huang, Xianhua Zhang, Xianhua Zhang, Xinliang Ma   +9 more
core   +3 more sources

Baicalin alleviates angiotensin II‐induced cardiomyocyte apoptosis and autophagy and modulates the AMPK/mTOR pathway

Journal of Cellular and Molecular Medicine
As a main extraction compound from Scutellaria baicalensis Georgi, Baicalin exhibits various biological activities. However, the underlying mechanism of Baicalin on hypertension‐induced heart injury remains unclear.
Ying Cheng, Mengchao Yan, Shuyu He, Yi Xie, Li-hui Wei, Bihan Xuan, Zucheng Shang, Mei-zhu Wu, Huifang Zheng, You-qin Chen, Meng Yuan, Jun Peng, A-ling Shen   +12 more
semanticscholar   +1 more source

Harnessing nanomaterials to precisely regulate the immunosuppressive tumor microenvironment for enhanced immunotherapy

BMEMat, EarlyView.
The immunosuppressive tumor microenvironment, characterized by hypoxia, redox imbalance, elevated interstitial fluid pressure, and acidity, was comprehensively elucidated. This review discussed the etiology and consequences of the characteristics of the immunosuppressive tumor microenvironment, and analyzed the recent advancements in nanomaterials for ...
Wen Zhang, Xueyin Hu, Wei Cheng, Lumeng Zhang, Yuanfang Chen, Qinrui Fu, Luntao Liu, Saijun Fan   +7 more
wiley   +1 more source

Baicalin Attenuates Cardiac Dysfunction and Myocardial Remodeling in a Chronic Pressure-Overload Mice Model

Cellular Physiology and Biochemistry, 2017
Background/Aims: Baicalin has been shown to be effective for various animal models of cardiovascular diseases, such as pulmonary hypertension, atherosclerosis and myocardial ischaemic injury.
Yanqing Zhang, Pingping Liao, Meng’en Zhu, Wei Li, Dan Hu, Siming Guan, Long Chen   +6 more
doaj   +1 more source

Consecutive baicalin treatment relieves its accumulation in rats with intrahepatic cholestasis by increasing MRP2 expression

Heliyon, 2023
Baicalin, an important flavonoid isolated from Scutellaria baicalensis Georgi, is a Chinese herb widely used in clinical practice. We previously reported the in vivo accumulation of baicalin in rats with intrahepatic cholestasis (IHC) after a single dose.
Yue Zu, Yanan Liu, Lulu Lan, Chen Zhu, Chengliang Zhang, Dong Liu   +5 more
doaj   +1 more source

Identity issues surrounding American skullcap (Scutellaria lateriflora) and an optimised high performance liquid chromatography method to authenticate commercially available products [PDF]

Traditional use of American skullcap (Scutellaria lateriflora) for anxiety and related conditions is well documented. There is evidence of flavonoid instability in S. lateriflora and a high rate of substitution with other skullcap species or adulteration
Awad, Barceloux, Bedir, Ciddi, de Oliveira, de Smet, Eclectic Institute Inc., Farrell, Felter, Foster, Gafner, Gafner, Gao, Gorman, Greenfield, Joshee, Khosh, Kuhn, Lin, Luthria, Malikov, Rader, Russell, U.S.D.A., Upton, Upton, Wills, Wohlmuth, Wohlmuth, Wohlmuth, Wolfson, Yaghmai, Yarnell, Zhang   +33 more
core   +1 more source