β-Barrel Assembly Machinery (BAM) Complex as Novel Antibacterial Drug Target [PDF]
Molecules, 2023 The outer membrane of Gram-negative bacteria is closely related to the pathogenicity and drug resistance of bacteria. Outer membrane proteins (OMPs) are a class of proteins with important biological functions on the outer membrane.
Qian Xu, Min Guo, Feiyuan Yu
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Distortion of the bilayer and dynamics of the BAM complex in lipid nanodiscs [PDF]
Communications Biology, 2020 With cryo-EM, single-molecule FRET and MD simulations, Iadanza et al. characterise the membrane protein insertase complex BAM in lipid bilayer nanodiscs.
Matthew G. Iadanza +11 more
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BB0324 and BB0028 are constituents of the
BMC Microbiology, 2012 Background Similar to Gram-negative bacteria, the outer membrane (OM) of the pathogenic spirochete, Borrelia burgdorferi, contains integral OM-spanning proteins (OMPs), as well as membrane-anchored lipoproteins.
Lenhart Tiffany R +4 more
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Combining Cell Envelope Stress Reporter Assays in a Screening Approach to Identify BAM Complex Inhibitors. [PDF]
ACS Infect Dis, 2021 The development of new antibiotics is particularly problematic in Gram-negative bacteria due to the presence of the outer membrane (OM), which serves as a permeability barrier. Recently, the β-barrel assembly machine (BAM), located in the OM and responsible for β-barrel type OM protein (OMP) assembly, has been validated as a novel target for ...
Steenhuis M +9 more
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Lateral opening in the intact β-barrel assembly machinery captured by cryo-EM [PDF]
Nature Communications, 2016 The β-barrel assembly machinery (BAM complex) is a key mediator of outer membrane protein biogenesis in Gram-negative bacteria. Here the authors report a cryo-EM structure of the intact BAM complex that suggests that lateral gate opening is a necessary ...
Matthew G. Iadanza +7 more
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Dynamic interplay between the periplasmic chaperone SurA and the BAM complex in outer membrane protein folding. [PDF]
Commun Biol, 2022 Schiffrin B +6 more
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Improper Coordination of BamA and BamD Results in Bam Complex Jamming by a Lipoprotein Substrate [PDF]
mBio, 2019 The β-barrel assembly machinery, the Bam complex, is central to the biogenesis of integral outer membrane proteins (OMPs) as well as OMP-dependent surface-exposed lipoproteins, such as regulator of capsule synthesis protein F (RcsF).
Muralidhar Tata, Anna Konovalova
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The Synthetic Phenotype of Δ
mBio, 2019 The selective permeability of the Gram-negative outer membrane (OM) is maintained by integral β-barrel outer membrane proteins (OMPs). The heteropentomeric β-barrel assembly machine (Bam) folds and inserts OMPs into the OM.
Elizabeth M. Hart +3 more
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Overexpression of the Bam Complex Improves the Production of Chlamydia trachomatis MOMP in the E. coli Outer Membrane. [PDF]
Int J Mol Sci, 2022 Huynh DT +4 more
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A minimum functional form of the Escherichia coli BAM complex constituted by BamADE assembles outer membrane proteins in vitro. [PDF]
J Biol ChemWang Z +10 more
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