Results 71 to 80 of about 884 (154)

Integration of SFTSV Viral Load, Age, and Double‐Negative B‐Cells as Prognostic Biomarkers for Severe Fever With Thrombocytopenia Syndrome Outcomes

Journal of Immunology Research, Volume 2026, Issue 1, 2026.
Background Severe fever with thrombocytopenia syndrome (SFTS) is a tick‐borne viral illness with high mortality, yet early risk stratification remains challenging. Recent evidence suggests that B‐cell dysregulation contributes to disease severity. Methods A cohort of 168 patients with confirmed SFTS was retrospectively analyzed. Flow cytometry was used
Wei Wei, Qian Tai, Heng Liu, Rujia Chen, Yun Wang, Ting Wang, Renren Ouyang, Shiji Wu, Feng Wang, Hongyan Hou, Poorani Gurumallesh   +10 more
wiley   +1 more source

Broad‐Spectrum Antiviral Agents against SARS‐CoV‐2 Variants Inhibit the Conserved Viral Protein Nsp1–RNA Interaction

Angewandte Chemie, Volume 136, Issue 47, November 18, 2024.
The demand for robust antiviral approaches is underscored by the continued COVID‐19 spread. SARS‐CoV‐2 Nsp1, highly conserved among SARS‐CoV‐2 variants, plays a pivotal role in controlling host protein expression and viral RNA translation. A small‐molecule Nsp1 inhibitor exhibited antiviral activity against various sarbecoviruses, signifying a ...
Wan Gi Byun, Minha Lee, Meehyun Ko, Ji Hyae Lee, Sihyeong Yi, JinAh Lee, Seungtaek Kim, Seung Bum Park   +7 more
wiley   +2 more sources

Pathogenesis and virulence of Heartland virus

Virulence
Heartland virus (HRTV), an emerging tick-borne pathogenic bunyavirus, has been a concern since 2012, with an increasing incidence, expanding geographical distribution, and high pathogenicity in the United States.
Kuan Feng, Benjamin Bendiwhobel Ushie, Haiyan Zhang, Shu Li, Fei Deng, Hualin Wang, Yun-Jia Ning   +6 more
doaj   +1 more source

A machine learning model for mortality prediction in patients with severe fever with thrombocytopenia syndrome: a prospective, multicenter cohort study

Emerging Microbes and Infections
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease that imposes a considerable medical burden. In this study, we enrolled 1,606 SFTS patients, developed and validated machine learning models for mortality prediction, and
Yanan Liu, Lei Fan, Wencai Wang, Hongxuan Song, Zhenhua Zhang, Qian Liu, Zhongji Meng, Shibo Li, Hua Wang, Shijun Zhou, Wanjun Liu, Guomei Xia, Jianping Duan, Chunxia Guo, Lu Wang, Ling Xu, Tong Wang, Hanxin Li, Xinyue Zhang, Tiandan Xiang, Di Liu, Zujiang Yu, Yuliang Liu, Junzhong Wang, Xin Zheng   +24 more
doaj   +1 more source

Animal Model of Severe Fever With Thrombocytopenia Syndrome Virus Infection

Frontiers in Microbiology, 2022
Severe fever with thrombocytopenia syndrome (SFTS), an emerging life-threatening infectious disease caused by SFTS bunyavirus (SFTSV; genus Bandavirus, family Phenuiviridae, order Bunyavirales), has been a significant medical problem.
Jiawen Sun, Jiawen Sun, Yuan-Qin Min, Yuan-Qin Min, Yunjie Li, Xiulian Sun, Xiulian Sun, Fei Deng, Fei Deng, Hualin Wang, Hualin Wang, Yun-Jia Ning, Yun-Jia Ning   +12 more
doaj   +1 more source

Recent Advances in Humoral Immunity Dysregulation in Severe Fever With Thrombocytopenia Syndrome Virus (SFTSV) Infection: A Systematic Review

Health Science Reports, Volume 8, Issue 10, October 2025.
ABSTRACT Background and Aims Severe fever with thrombocytopenia syndrome virus (SFTSV) infection causes profound dysregulation of humoral immunity, leading to immunopathology and impaired viral clearance. However, the mechanisms underlying B cell dysfunction and inadequate antibody responses remain poorly defined.
Hongyan Hou, Xu Yuan, Rujia Chen, Zhigang Xiong, Shiji Wu, Feng Wang   +5 more
wiley   +1 more source

Macroevolution of virulence shifts in human-infective RNA virus species [PDF]

, 2023
Study Objectives: To determine the frequency and distribution of virulence shifts across 40 viral genera that include human-infective RNA virus species using evolutionary discrete trait models. Methods: An inhouse database containing RNA-dependent RNA
Dalhuisen, Thomas
core   +1 more source

Effective treatment of advanced Oropouche virus, Rift Valley fever virus, and Dabie bandavirus infections with 4'-fluorouridine. [PDF]

mBio
ABSTRACT Oropouche virus (OROV), Rift Valley fever virus (RVFV), and Dabie bandavirus (DBV) are significant re-emerging and emerging human pathogens with major public health implications. Notably, the ongoing OROV disease epidemic spanning South America, Central America, and the Caribbean now exceeds 11,000 cases ...
Westover JB, Jung KH, Rojas I, Bailey KW, Landinez-Aponte J, Blumeling GR, Mao S, Kolykhalov AA, Natchus MG, Painter GR, Gowen BB.   +10 more
europepmc   +3 more sources

Multiple Introductions of the Asian Longhorned Tick (Haemaphysalis longicornis) to the United States Revealed Using Mitogenomics

Ecology and Evolution, Volume 15, Issue 4, April 2025.
The Asian longhorned tick, Haemaphysalis longicornis, is a significant global vector and threat to both agriculture and public health. Formerly known only in the Eastern Hemisphere, parthenogenetic ALT have been reported from 20 states across the eastern and central US, with a pattern of expansion suggestive of multiple distinct populations.
Zoe E. Narvaez, Andrea M. Egizi, Michael J. Yabsley, Alec T. Thompson, Mohamed Moustafa, Erika Alt, Matthew Bickerton, Kim Bjorgo, Rebecca A. Butler, Alexandra Cumbie, Gillian Eastwood, Richard C. Falco, Dina M. Fonseca, Jun Hang, Vanessa L. Harper, Nicole Lewis, Jan Lovy, Lauren P. Maestas, Thomas N. Mather, Ryo Nakao, James L. Occi, Tadhgh Rainey, Melanie Sal, Craig A. Stoops, Rebecca T. Trout‐Fryxell, Wes Watson, Nicole E. Wagner, Aihua Zheng, Perot Saelao, Dana C. Price   +29 more
wiley   +1 more source

Geriatric Nutritional Risk Index Plays Important Role in Predicting In‐Hospital Mortality in Patients With Severe Fever With Thrombocytopenia Syndrome: A Multi‐Center Observational Study

Journal of Medical Virology, Volume 97, Issue 2, February 2025.
ABSTRACT Geriatric nutritional risk index (GNRI) has been proposed as a reliable indicator of nutritional state and, when decreased, is closely associated with the severity and mortality risk of infectious disease. The current study retrospectively recruited patients who were admitted for SFTS from January 1, 2011 to January 1, 2024 at six medical ...
Tingyu Zhang, Yanli Xu, Ziruo Ge, Di Tian, Chenxi Zhao, Qi Zhao, Ling Lin, Zhensheng Liu, Zhihai Chen   +8 more
wiley   +1 more source