Results 71 to 80 of about 3,184,320 (288)

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Mutations in BIN1 associated with centronuclear myopathy disrupt membrane remodeling by affecting protein density and oligomerization. [PDF]

PLoS ONE, 2014
The regulation of membrane shapes is central to many cellular phenomena. Bin/Amphiphysin/Rvs (BAR) domain-containing proteins are key players for membrane remodeling during endocytosis, cell migration, and endosomal sorting. BIN1, which contains an N-BAR
Tingting Wu, Zheng Shi, Tobias Baumgart
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Coordination of membrane and actin cytoskeleton dynamics during filopodia protrusion. [PDF]

PLoS ONE, 2009
Leading edge protrusion of migrating cells involves tightly coordinated changes in the plasma membrane and actin cytoskeleton. It remains unclear whether polymerizing actin filaments push and deform the membrane, or membrane deformation occurs ...
Changsong Yang, Matthew Hoelzle, Andrea Disanza, Giorgio Scita, Tatyana Svitkina   +4 more
doaj   +1 more source

Sobolev regularity of the canonical solutions to $\bar\partial$ on product domains

Comptes Rendus. Mathématique, 2022
Let $Ω$ be a product domain in $\mathbb C^n, n\ge 2$, where each slice has smooth boundary. We observe that the canonical solution operator for the $\bar\partial$ equation on $Ω$ is bounded in $W^{k,p}(Ω)$, $k\in \mathbb Z ...
openaire   +4 more sources

A Prokaryotic Membrane Sculpting BAR Domain Protein [PDF]

, 2020
Abstract Bin/Amphiphysin/RVS (BAR) domain proteins belong to a superfamily of coiled-coil proteins influencing membrane curvature in eukaryotes and are associated with vesicle biogenesis, vesicle-mediated protein trafficking, and intracellular signaling.
Daniel A. Phillips, Lori A. Zacharoff, Cheri M. Hampton, Grace W. Chong, Anthony P. Malanoski, Lauren Ann Metskas, Shuai Xu, Lina J. Bird, Brian J. Eddie, Grant J. Jensen, Lawrence F. Drummy, Mohamed Y. El-Naggar, Sarah M. Glaven   +12 more
openaire   +1 more source

Molecular basis for SH3 domain regulation of F Bar mediated membrane deformation

, 2010
Members of the Bin/amphiphysin/Rvs (BAR) domain protein superfamily are involved in membrane remodeling in various cellular pathways ranging from endocytic vesicle and T-tubule formation to cell migration and neuromorphogenesis.
Ma, Qingjun, Ma, Q, Puchkov, Dmytro, Sundborger, A, Rao, Yijian, Luo, L., Haucke, V, Haucke, V., Sundborger, Anna, Rao, Y, Puchkov, D., Vahedi Faridi, A., Saenger, W., Rao, Y., Haucke, Volker, Vahedi-Faridi, Ardeschir, Vahedi-Faridi, A, Luo, L, Shupliakov, O., Pechstein, A., Saenger, Wolfram, Saenger, W, Luo, Lin, Sundborger, A., Pechstein, A,, Ma, Q., Shupliakov, O,, Puchkov, D, Shupliakov, Oleg, Pechstein, Arndt   +29 more
core   +1 more source

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

GRAF1 forms a complex with MICAL-L1 and EHD1 to cooperate in tubular recycling endosome vesiculation

Frontiers in Cell and Developmental Biology, 2014
The biogenesis of tubular recycling endosomes (TREs) and their subsequent vesiculation after cargo-sorting has occurred, is essential for receptor and lipid recycling to the plasma membrane.
Bishuang eCai, Shuwei eXie, Steve eCaplan, Naava eNaslavsky   +3 more
doaj   +1 more source