Results 51 to 60 of about 641,315 (246)
New Insights into BAR Domain-Induced Membrane Remodeling [PDF]
Biophysical Journal, 2009 Mesoscopic simulations and electron microscopy of N-BAR domain-induced liposome remodeling are used to characterize the process of liposome tubulation and vesiculation. The overall process of membrane remodeling is found to involve complex couplings among the N-BAR protein density, the degree of N-BAR oligomerization, and the membrane density.
Ayton, Gary S. +6 more
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Membrane Curvature: How BAR Domains Bend Bilayers [PDF]
Current Biology, 2004 An important new structure suggests the BAR domain is a membrane-binding module that can both produce and sense membrane curvature. BAR resembles a banana that binds membranes electrostatically through its positively charged, concave surface.
Zimmerberg, Joshua, McLaughlin, Stuart
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Tailoring magnetization reversal of a single-domain bar nanomagnet via its end geometry
AIP Advances, 2021 Nanoscale single-domain bar magnets are building blocks for a variety of fundamental and applied mesoscopic magnetic systems, such as artificial spin ices, magnetic shape-morphing microbots, and magnetic majority logic gates.
Jianhua Li +14 more
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Membrane-Bending Mechanism of Amphiphysin N-BAR Domains [PDF]
Biophysical Journal, 2009 BAR domains are highly conserved protein domains participating in a diversity of cellular processes that involve membrane remodeling. The mechanisms underlying such remodeling are debated. For the relatively well-studied case of amphiphysin N-BAR domain, one suggested mechanism involves scaffolding, i.e., binding of a negatively charged membrane to the
Arkhipov, Anton +2 more
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Membrane sculpting by curved DNA origami scaffolds
Nature Communications, 2018 BAR domain proteins feature a “banana-like” shape which is thought to aid membrane scaffolding and membrane tubulation. Here authors use DNA origami mimicking BAR domains, giant unilamellar vesicles and fluorescence imaging to study how different BAR ...
Henri G. Franquelim +4 more
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Revisiting I-BAR Proteins at Central Synapses
Frontiers in Neural Circuits, 2021 Dendritic spines, the distinctive postsynaptic feature of central nervous system (CNS) excitatory synapses, have been studied extensively as electrical and chemical compartments, as well as scaffolds for receptor cycling and positioning of signaling ...
Christina Chatzi, Gary L. Westbrook
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The eisosome core is composed of BAR domain proteins
Molecular Biology of the Cell, 2011 Eisosomes define sites of plasma membrane organization. In Saccharomyces cerevisiae, eisosomes delimit furrow-like plasma membrane invaginations that concentrate sterols, transporters, and signaling molecules. Eisosomes are static macromolecular assemblies composed of cytoplasmic proteins, most of which have no known function.
Olivera-Couto, Agustina +3 more
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BAR Domain Scaffolds in Dynamin-Mediated Membrane Fission [PDF]
Cell, 2014 Biological membranes undergo constant remodeling by membrane fission and fusion to change their shape and to exchange material between subcellular compartments. During clathrin-mediated endocytosis, the dynamic assembly and disassembly of protein scaffolds comprising members of the bin-amphiphysin-rvs (BAR) domain protein superfamily constrain the ...
Daumke, Oliver +2 more
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The cryo-EM structure of the SNX–BAR Mvp1 tetramer
Nature Communications, 2020 SNX-BAR proteins are a family of PX and BAR domain-containing proteins with pivotal roles in trafficking processes. Here authors present the cryo-EM structure of the full-length fungal SNX-BAR Mvp1, which is an autoinhibited tetramer and provides ...
Dapeng Sun +5 more
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A PX-BAR protein Mvp1/SNX8 and a dynamin-like GTPase Vps1 drive endosomal recycling
eLife, 2021 Membrane protein recycling systems are essential for maintenance of the endosome-lysosome system. In yeast, retromer and Snx4 coat complexes are recruited to the endosomal surface, where they recognize cargos. They sort cargo and deform the membrane into
Sho W Suzuki +5 more
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