Results 91 to 100 of about 35,118 (233)

Efficacy and safety of a selective partial agonist for nociception/orphanin‐FQ peptide (NOP) receptors in patients with insomnia disorder

open access: yesBritish Journal of Clinical Pharmacology, Volume 92, Issue 1, Page 172-185, January 2026.
Aims Insomnia is a common sleep disorder, affecting up to 20% of the world population and adversely impacting productivity, health, and overall well‐being. Although pharmacologic options exist to treat insomnia, the health‐related quality of life for patients who are prescribed hypnotics is no higher than for those who are not, revealing a significant ...
Garth T. Whiteside   +5 more
wiley   +1 more source

Triethylammonium 2,4-dinitrophenylbarbiturate

open access: yesActa Crystallographica Section E, 2009
In the title molecular salt [systematic name: triethylammonium 5-(2,4-dinitrophenyl)-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-olate], C6H16N+·C10H5N4O7−, the cation and anion are linked by an N—H...O hydrogen bond.
Doraisamyraja Kalaivani   +1 more
doaj   +1 more source

L‐Quebrachitol Enhances Sedative Effect of Diazepam Through GABAergic Pathway: Animal and Computational Studies

open access: yesBrain and Behavior, Volume 16, Issue 1, January 2026.
L‐quebrachitol (LQL) significantly enhanced the sedative effects of diazepam in thiopental sodium‐induced chicks by reducing sleep latency and prolonging duration. Molecular docking revealed LQL's interaction with GABAA receptor (α1 and β2 subunits), supporting a GABAergic mechanism and highlighting its potential as a safe, natural sedative agent ...
Asifa Asrafi   +9 more
wiley   +1 more source

Studies on identification of menstrual blood stain by fibrin-plate method. I. A study on the incoagulability of menstrual blood [PDF]

open access: yes, 1962
As the results of present study on plasmin in menstrual blood by means of the Fibrin-Plate Method, a large amount of plasmin as much as dilution of 1: 100 or 1:1,000 of the menstrual blood serum, has been found in a natural form and it is deduced that ...
Shiraishi, Masumi
core   +1 more source

Association Between Dietary Fatty Acid Intake With Cardiovascular Disease Risk and Serum Lipid Levels

open access: yesEndocrinology, Diabetes &Metabolism, Volume 9, Issue 1, January 2026.
The findings suggest a protective role of MUFA intake against CVDs risk. ABSTRACT Background Despite early interest in the effects of dietary fats on cardiovascular diseases (CVDs), substantial controversy remains regarding the evidence linking different types of fatty acids to CVDs.
Naeemeh Hassanpour Ardekanizadeh   +12 more
wiley   +1 more source

Exploratory Pain Profiling With Quantitative Sensory Testing (QST) in Episodic and Chronic Migraine

open access: yesEuropean Journal of Pain, Volume 30, Issue 1, January 2026.
ABSTRACT Background Migraine pain profiling studies vary by sensory modalities, methods, anatomical sites and characteristics. This exploratory study aimed to identify pain profiling parameters using quantitative sensory testing (QST) for episodic migraine (EM) and chronic migraine (CM) and investigate potential differences, given conflicting results ...
Rein F. van Welie   +5 more
wiley   +1 more source

Overdose rescues by trained and untrained participants and change in opioid use among substance-using participants in overdose education and naloxone distribution programs: a retrospective cohort study [PDF]

open access: yes, 2014
Background: One approach to preventing opioid overdose, a leading cause of premature, preventable mortality, is to provide overdose education and naloxone distribution (OEND). Two outstanding issues for OEND implementation include 1) the dissemination of
Doe-Simkins, Maya   +6 more
core   +3 more sources

Medulla Tetrapanacis Water Extract Ameliorates Dextran Sulfate Sodium‐Induced Ulcerative Colitis by Reprogramming Macrophage Polarization and Maintaining Intestinal Barrier Integrity

open access: yesFood Frontiers, Volume 7, Issue 1, January 2026.
The protective effects of Medulla Tetrapanacis (MT) water extract on dextran sulfate sodium‐induced ulcerative colitis (UC) were examined both in vivo (mouse and zebrafish) and in vitro. The effect of MT on UC was mediated by regulating macrophage polarization, ameliorating oxidative stress, and preserving an intact intestinal barrier. The effect of MT
Yanfen Cheng   +10 more
wiley   +1 more source

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