Results 81 to 90 of about 27,224 (236)
Advanced Materials, Volume 38, Issue 26, 8 May 2026.A novel FIRINOX‐loaded implant demonstrates controlled drug release, and potent therapeutic efficacy in pancreatic ductal adenocarcinoma mouse models with safety confirmed in a large‐animal pre‐clinical model. This innovative drug delivery platform offers a promising new treatment approach for non‐resectable, treatment‐resistant pancreatic cancer ...
Samantha J. Wade +19 more
wiley +1 more source
State-Dependent Modulation of Slow Wave Motifs towards Awakening
Frontiers in Cellular Neuroscience, 2017 Slow cortical waves that propagate across the cerebral cortex forming large-scale spatiotemporal propagation patterns are a hallmark of non-REM sleep and anesthesia, but also occur during resting wakefulness.
Thomas Knöpfel +6 more
doaj +1 more source
Inhalation of Isopropyl Alcohol Leading to Acute Severe Toxicity: A Case Report
Clinical Case Reports, Volume 14, Issue 5, May 2026.ABSTRACT This case represents the first reported instance of adult isopropyl alcohol inhalation intoxication with a rapid onset (2 h) and initially negative serum and urine ketones. It highlights that early isopropyl alcohol intoxication may not exhibit the typical clinical features, such as respiratory depression, altered mental status, and positive ...
Ben Thiravetyan +7 more
wiley +1 more source
ProceedingsIntroduction: Methaqualone was introduced to the market in the 1960s as a sedative–hypnotic drug, intended as an alternative to compounds in the barbiturate group [...]
Kaja Tusiewicz +2 more
doaj +1 more source
Triethylammonium 1,3-dimethyl-5-(2,4,6-trinitrophenyl)barbiturate
Acta Crystallographica Section E, 2012 In the title molecular salt [systematic name: triethylammonium 1,3-dimethyl-2,6-dioxo-5-(2,4,6-trinitrophenyl)-1,2,3,6-tetrahydropyrimidin-4-olate], C6H16N+·C12H8N5O9−, the dihedral angle between the aromatic rings in the anion is 46 ...
Kulandaiya Rajamani +1 more
doaj +1 more source
Osteochondrosis lesions of the lateral trochlear ridge of the distal femur in four ponies [PDF]
, 2011 Lesions of the lateral trochlear ridge (LTR) of the distal femur were investigated in four pony or pony cross horses. The animals were all geldings and were six to 15 months of age.
Henson, F.M.D. +3 more
core +1 more source
Population Pharmacokinetics and Dosing Simulations of Pentobarbital in the Pediatric Population
The Journal of Clinical Pharmacology, Volume 66, Issue 5, May 2026.Abstract Pentobarbital is a barbiturate with sedative and anticonvulsant properties, occasionally used in pediatric patients for preoperative sedation, deep sedation during mechanical ventilation, and seizure control. Despite its long‐standing clinical use, age‐appropriate dosing remains challenging due to variability across studies and limited ...
Victoria Etges Helfer +12 more
wiley +1 more source
Case Reports in Dermatology, 2009 Coma blisters are lesions that occur in the setting of a variety of neurological diseases. Although most commonly associated with barbiturate overdose, they can be seen in the setting of coma due to other etiologies.
Joana Rocha +4 more
doaj +1 more source
Pharmaceutical research in Wilhelmine Germany: The case of E. Merck [PDF]
In this paper, we describe the emergence and evolution of pharmaceutical research at the German company E. Merck during the late 19th and early 20th century.
Carsten Burhop
core
Journal of Forensic Sciences, Volume 71, Issue 3, Page 1329-1337, May 2026.Abstract The rising rate of drug‐related deaths in the United States, largely driven by fentanyl, requires timely and accurate surveillance. However, critical overdose data are often buried in free‐text coroner reports, leading to delays and information loss when coded into ICD (International Classification of Disease)‐10 classifications.
Arthur J. Funnell +8 more
wiley +1 more source