Results 61 to 70 of about 13,944 (198)

Clonidine-Activation of Epileptic Foci

open access: yesPediatric Neurology Briefs, 1998
The effects of clonidine, an adrenergic a2 agonist hypotensive agent, and methoxital, a short-acting barbiturate anesthetic, on epileptiform discharges detected by presurgical magnetoencephalography (MEG) were investigated in 14 patients with medically ...
J Gordon Millichap
doaj   +1 more source

Mesotherapy With Lidocaine and Ketamine in Complex Regional Pain Syndrome Type 1: A Randomized Double‐Blind Trial

open access: yesPain Practice, Volume 26, Issue 7, September 2026.
ABSTRACT Background Complex regional pain syndrome type 1 (CRPS1) is a disabling pain syndrome whose treatment remains challenging. Mesotherapy is a therapeutic method involving the injection of low doses of active substances through the skin. No studies assessed mesotherapy in CRPS1 patients.
Philippe Lafuma   +12 more
wiley   +1 more source

A Historical Drug or a Current Problem? Determination of Methaqualone and Its Analogs in Biological Material via UHPLC-QqQ-MS/MS

open access: yesProceedings
Introduction: Methaqualone was introduced to the market in the 1960s as a sedative–hypnotic drug, intended as an alternative to compounds in the barbiturate group [...]
Kaja Tusiewicz   +2 more
doaj   +1 more source

State-Dependent Modulation of Slow Wave Motifs towards Awakening

open access: yesFrontiers in Cellular Neuroscience, 2017
Slow cortical waves that propagate across the cerebral cortex forming large-scale spatiotemporal propagation patterns are a hallmark of non-REM sleep and anesthesia, but also occur during resting wakefulness.
Thomas Knöpfel   +6 more
doaj   +1 more source

Diastereoselective Synthesis of Polysubstituted 2‐Amidino Thiolanes via Cycloaddition of N‐Thioacyl Amidines With Donor–Acceptor Cyclopropanes

open access: yesAdvanced Synthesis &Catalysis, Volume 368, Issue 16, 18 August 2026.
A MgBr2‐catalyzed (3+2) cycloaddition between N‐thioacyl amidines and donor–acceptor cyclopropanes provides rapid access to 2‐amidino‐thiolanes in good yields and with high diastereoselectivities. The method displays broad substrate scope and offers an efficient route to sulfur‐containing amidine scaffolds of potential biological relevance.
Laurine Tual   +4 more
wiley   +1 more source

Triethylammonium 1,3-dimethyl-5-(2,4,6-trinitrophenyl)barbiturate

open access: yesActa Crystallographica Section E, 2012
In the title molecular salt [systematic name: triethylammonium 1,3-dimethyl-2,6-dioxo-5-(2,4,6-trinitrophenyl)-1,2,3,6-tetrahydropyrimidin-4-olate], C6H16N+·C12H8N5O9−, the dihedral angle between the aromatic rings in the anion is 46 ...
Kulandaiya Rajamani   +1 more
doaj   +1 more source

Recurrent Hypothermia and Autonomic Dysfunction Secondary to Shapiro Syndrome

open access: yesAnnals of Clinical and Translational Neurology, Volume 13, Issue 8, Page 1719-1725, August 2026.
ABSTRACT A 44‐year‐old man presented with recurrent hypothermia, diaphoresis and hypertension. Extensive investigation for infectious, inflammatory, metabolic and endocrine aetiologies was negative. MR scan of the brain demonstrated no lesions but revealed callosal dysgenesis, consistent with Shapiro syndrome.
Naveen Kumar   +3 more
wiley   +1 more source

Coma Blisters

open access: yesCase Reports in Dermatology, 2009
Coma blisters are lesions that occur in the setting of a variety of neurological diseases. Although most commonly associated with barbiturate overdose, they can be seen in the setting of coma due to other etiologies.
Joana Rocha   +4 more
doaj   +1 more source

Identification of Barbiturates [PDF]

open access: yesNature, 1959
IN Great Britain the most common poisons at the present time are the 5 : 5′ disubstituted barbiturates. The longer-acting barbiturates, barbitone and phenobarbitone, can accumulate in the body when administered in relatively low therapeutic dosage, and concentrations of these drugs in the blood of about 5 mgm./100 ml. do not necessarily imply poisoning.
openaire   +2 more sources

Barbituric Acids as Nucleophiles in Enantioselective Mannich Reactions: Organocatalytic Access to Quaternary Aminopyrazolone–Barbiturate Adducts

open access: yesAdvanced Synthesis &Catalysis, Volume 368, Issue 15, 1 August 2026.
An enantioselective Mannich reaction using barbituric acids as nucleophiles provides access to chiral heterocycles bearing quaternary stereocenters. The transformation is catalyzed by a bifunctional thiourea with high selectivity. An immobilized catalyst enables recycling and application under continuous‐flow conditions, offering an efficient and ...
Rodrigo Sánchez‐Molpeceres   +4 more
wiley   +1 more source

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